An improved method for Organic Bound Tritium (OBT) determination in urine samples.

Abstract:

:The Organic Bound Tritium (OBT) amount in the body may induce changes in the evaluation of the internal exposure to tritium, due to its different retention time relative to HTO. OBT measurements for urine are not performed routinely, mainly because of the lengthy work needed in preparation of the samples, when using the standard oxygen combustion method. A simpler and more rapid method based on liquid scintillation counting (LSC) was employed, and an evaluation was performed to check its suitability for urine samples. The principle of the proposed method is based on subtracting the LSC counts of the water phase sample (HTO) from the total activity of the urine sample (OBT+HTO). A good correlation was found between the results obtained when applying the proposed direct method and the Gold standard method. The minimum detectable activity when using this method was determined.

journal_name

Radiat Prot Dosimetry

authors

Gonen R,Marco R,German U,Katorza E,Alfassi ZB,Haquin G,Tshuva A,Pelled O

doi

10.1093/rpd/ncm148

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

460-4

issue

1-4

eissn

0144-8420

issn

1742-3406

pii

ncm148

journal_volume

125

pub_type

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