Role of the heat shock response in stability of mRNA in Escherichia coli K-12.

Abstract:

:The heat shock response in Escherichia coli involves extensive induction of the heat shock proteins, with the concomitant suppression of the synthesis of the non-heat shock proteins. While the induction of the heat shock proteins has been shown to occur primarily at the transcriptional level, the suppression of non-heat shock proteins is poorly understood. We have investigated the possibility that an increased decay of non-heat shock mRNAs is a means of decreasing the synthesis of non-heat shock proteins during the heat shock response. Heat shock response-defective strains were compared with wild-type controls by several criteria to evaluate both mRNA stability and the induction of enzymes known to be involved in mRNA turnover. Our results indicate that increased mRNA decay is not a mechanism used to regulate the synthesis of non-heat shock proteins.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Henry MD,Yancey SD,Kushner SR

doi

10.1128/jb.174.3.743-748.1992

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

743-8

issue

3

eissn

0021-9193

issn

1098-5530

journal_volume

174

pub_type

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