Effects of mutations to streptomycin resistance on the rate of translation of mutant genetic information.

Abstract:

:Gartner, T. K. (University of California, Santa Barbara), and E. Orias. Effects of mutations to streptomycin resistance on the rate of translation of mutant genetic information. J. Bacteriol. 91:1021-1028. 1966.-The effects of mutations to streptomycin resistance of independent origin upon the translation of suppressible mutant information were studied in an isogenic series of strains of Escherichia coli. The group of suppressible mutants included 1 mutation in the z gene of the lac operon of E. coli (O(0) (2) allele), 12 mutations distributed among the two rII cistrons of T4, and 13 mutations distributed among at least five cistrons of phage T7. It was concluded that the mutations to streptomycin resistance cause a significant decrease in the rate of translation of the suppressible codons, and that this effect is limited to a few types of codons.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Gartner TK,Orias E

doi

10.1128/JB.91.3.1021-1028.1966

subject

Has Abstract

pub_date

1966-03-01 00:00:00

pages

1021-8

issue

3

eissn

0021-9193

issn

1098-5530

journal_volume

91

pub_type

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