Placental transfer of long-chain polyunsaturated fatty acids (LC-PUFA).

Abstract:

:Considerable evidence exists for marked beneficial effects of omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) during pregnancy. The omega-3 LC-PUFA docosahexaenoic acid (DHA) is incorporated in large amounts in fetal brain and other tissues during the second half of pregnancy, and several studies have provided evidence for a link between early DHA status of the mother and visual and cognitive development of her child after birth. Moreover, the supplementation of omega-3 LC-PUFA during pregnancy increases slightly infant size at birth, and significantly reduces early preterm birth before 34 weeks of gestation by 31%. In our studies using stable isotope methodology in vivo, we demonstrated active and preferential materno-fetal transfer of DHA across the human placenta and found the expression of human placental fatty acid binding and transport proteins. From the correlation of DHA values with placental fatty acid transport protein 4 (FATP 4), we conclude that this protein is of key importance in mediating DHA transport across the human placenta. Given the great importance of placental DHA transport for infant outcome, further studies are needed to fully appreciate the effects and optimal strategies of omega-3 fatty acid interventions in pregnancy, dose response relationships, and the potential differences between subgroups of subjects such as women with gestational diabetes or other gestational pathology. Such studies should contribute to optimize substrate intake during pregnancy and lactation that may improve pregnancy outcome as well as fetal growth and development.

journal_name

J Perinat Med

authors

Koletzko B,Larqué E,Demmelmair H

doi

10.1515/JPM.2007.030

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

S5-11

eissn

0300-5577

issn

1619-3997

journal_volume

35 Suppl 1

pub_type

杂志文章,评审
  • The role of fetal myoglobin in the initiation of human parturition.

    abstract::The aim of the present investigation is to study the effect of amniotic fluid myoglobin on prostaglandin synthesis by the fetal membranes. The paper presents results of radioimmunologic studies of myoglobin levels in various biological fluids during pregnancy: amniotic fluid, maternal serum samples obtained from an an...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1996.24.5.495

    authors: Orlov VI,Pogorelova TN,Melkonova KY

    更新日期:1996-01-01 00:00:00

  • Socio-cultural and clinician determinants in the maternal decision-making process in the choice for trial of labor vs. elective repeated cesarean section: a questionnaire comparison between Italian settings.

    abstract::Objective To identify socio-cultural and clinician determinants in the decision-making process in the choice for trial of labor after cesarean (TOLAC) or elective repeat cesarean section (ERCS) in delivering women. Methods A tailored questionnaire focused on epidemiological, socio-cultural and obstetric data was admin...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2019-0041

    authors: Triunfo S,Minciotti C,Burlon B,Giovannangeli F,Danza M,Tateo S,Lanzone A

    更新日期:2019-08-27 00:00:00

  • Mid-trimester amniotic fluid concentrations of the proinflammatory cytokines IL-6, IL-8, TNF-α, and lipopolysaccharide binding protein in normal pregnancies: a prospective evaluation according to parity, gestational age, and fetal gender.

    abstract:OBJECTIVE:To assess mid-trimester amniotic fluid concentrations of interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, and lipopolysaccharide binding protein (LBP) in pregnancies with normal outcome and correlate them with gestational week (GW), parity, and fetal gender. METHODS:Cytokine concentrations were measu...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm.2011.041

    authors: Bamberg C,Fotopoulou C,Linder M,Roehr CC,Dudenhausen JW,Henrich W,Kalache K

    更新日期:2011-07-01 00:00:00

  • Labour epidural analgesia and anti-infectious management of the neonate: a meta-analysis.

    abstract:BACKGROUND:A known side effect of labour epidural analgesia (EDA) is maternal fever. It is unclear whether this has effects on the anti-infectious management of the neonate. METHODS:A systematic literature search and a hand search of abstract publications were conducted. Studies reporting sepsis evaluation or antibiot...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,meta分析

    doi:10.1515/jpm-2012-0064

    authors: Heesen M,Klöhr S,Rossaint R,Straube S,Van de Velde M

    更新日期:2012-11-01 00:00:00

  • Limit of viability in Japan: ethical consideration.

    abstract::Viability means "the quality or state of being able to live, grow and develop." Limit of viability has been changed along with the advancement of perinatal and neonatal medicine. The viability limit defined in the Japanese Motherhood Protection Act was amended from 24 to 22 completed weeks of gestation in 1991 based o...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,评审

    doi:10.1515/JPM.2009.112

    authors: Nishida H,Sakuma I

    更新日期:2009-01-01 00:00:00

  • Intussusception in a preterm neonate; a very rare, major intestinal problem--systematic review of cases.

    abstract::Intussusception is an extremely rare disorder in preterm infants and it is often misdiagnosed as necrotizing enterocolitis. We report a case of intussusception in a 30-day-old preterm infant of 26 weeks of gestational age and a birthweight of 610 g who was diagnosed via abdominal ultra sonography. A systematic review ...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,评审

    doi:10.1515/JPM.2004.036

    authors: Martínez Biarge M,García-Alix A,Luisa del Hoyo M,Alarcón A,Sáenz de Pipaón M,Hernández F,Pérez J,Quero J

    更新日期:2004-01-01 00:00:00

  • Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study.

    abstract:OBJECTIVE:To examine the proportion of iatrogenic births among all preterm births over a 26-year period. PATIENTS AND METHODS:A registry-based survey of preterm deliveries between 1987 and 2012 analyzed by the onset of labor: spontaneous with intact membranes, preterm premature rupture of membranes (PPROM) or iatrogen...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2015-0271

    authors: Lucovnik M,Bregar AT,Steblovnik L,Verdenik I,Gersak K,Blickstein I,Tul N

    更新日期:2016-07-01 00:00:00

  • The somatic growth of a regional birth cohort of 351 preterm infants during the first two years of life.

    abstract::The somatic growth of a regional birth cohort of 351 preterm infants was followed during their first two years. The measurements of weight, height, head and thorax circumferences took place at the well-baby clinics run by public health nurses at 3, 6, 12, 18 and 24 months of conceptional age. The growth of the preterm...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1989.17.1.41

    authors: Piekkala P,Kero P,Sillanpää M,Erkkola R

    更新日期:1989-01-01 00:00:00

  • Systematic pH-measurements in the umbilical artery: causes and predictive value of neonatal acidosis.

    abstract::Subpartal and neonatal blood gas analyses have attracted increasing interest during the past 20 years. Different studies have been carried out to investigate the causes and immediate consequences of perinatal acidosis. It was the aim of this study to examine the long term outcome of acidotic-born babies. During 16 con...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1983.11.6.278

    authors: Lauener PA,Calame A,Janecek P,Bossart H,Monod JF

    更新日期:1983-01-01 00:00:00

  • Fetal face as important indicator of fetal brain function.

    abstract::Fetuses show various facial expressions, such as blinking, yawning, sucking, mouthing, tongue expulsion, scowling, and smiling, assessed by four-dimensional ultrasound from the early second trimester of pregnancy. Moreover, some fetuses demonstrate emotion-like behaviors as noted in infants, children, and adults. Sele...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,评审

    doi:10.1515/jpm-2016-0377

    authors: AboEllail MAM,Hata T

    更新日期:2017-08-28 00:00:00

  • Transcutaneous carbon dioxide measurements in the fetus during labor.

    abstract::Continuous transcutaneous carbon dioxide partial pressure (tcPco2) was monitored in 40 spontaneous labors. The electrode was attached by glue fixation. An interpretable tracing was obtained in 36 cases. All cases but 2 were normal pregnancies. Thirty-two patients had epidural analgesia while the others had no analgesi...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1987.15.4.390

    authors: Grandjean H,Centa M,Giroux M,Rorive C,Kobuch W,Pontonnier G

    更新日期:1987-01-01 00:00:00

  • Neonatal manifestations of maternal phencyclidine exposure.

    abstract::The purpose of this study was to determine the effects of maternal phencyclidine use on the fetus. Ninety-four neonates with maternal phencyclidine exposure were compared with 94 controls. Maternal phencyclidine use was assessed by questionnaire and repeated urine testing. Mothers of study and control patients were ma...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1987.15.2.185

    authors: Golden NL,Kuhnert BR,Sokol RJ,Martier S,Williams T

    更新日期:1987-01-01 00:00:00

  • The fetal electrocardiogram: current clinical developments in Nottingham.

    abstract::The fetal electrocardiogram (FECG) has been recorded from 155 women in labor using a fetal scalp electrode and a minicomputerized enhanced averaging technique. Fetal hypoxia, acidosis, and stress have been diagnosed by analysis of blood from the fetal scalp, and post delivery from full gas analysis from blood taken fr...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1986.14.6.399

    authors: Murray HG

    更新日期:1986-01-01 00:00:00

  • The impact of umbilical and uterine artery Doppler indices on antenatal course, labor and delivery in a low-risk primigravid population.

    abstract:AIMS:To evaluate the impact of umbilical and uterine artery Doppler in the second and third trimester on antenatal course, labor and delivery in a low-risk primigravid population. METHODS:Prospective recruitment of 1011 low-risk primigravidas with uterine and umbilical artery Doppler assessment at 22-24 weeks and 36 w...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm.2010.130

    authors: Cooley SM,Donnelly JC,Walsh T,MacMahon C,Gillan J,Geary MP

    更新日期:2011-03-01 00:00:00

  • Intermittent flushing improves cannula patency compared to continuous infusion for peripherally inserted venous catheters in newborns: results from a prospective observational study.

    abstract:AIMS:Peripheral cannulas in newborns are commonly used for intravenous treatment. However sustained maintenance of cannula patency is often difficult to achieve in this age group. This study compares the duration for which cannula patency can be maintained in newborns under continuous infusion, or an intermittent flush...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2011-1000

    authors: Perez A,Feuz I,Brotschi B,Bernet V

    更新日期:2012-01-19 00:00:00

  • Localization and quantification of adhesion molecule expression in the lower uterine segment during premature labor.

    abstract:AIMS:To investigate localization and concentration of adhesion molecules in the human lower uterine segment during preterm parturition. METHODS:In a prospective study biopsy specimens from the lower uterine segment of 43 patients undergoing cesarean section at 24 + 0 to 36 + 4 weeks' gestation were immunostained for i...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/JPM.2001.069

    authors: Fischer DC,Winkler M,Ruck P,Poth D,Kemp B,Rath W

    更新日期:2001-01-01 00:00:00

  • Neonatal screening for congenital hypothyroidism in Hessen, Germany: efficiency of the screening program and school achievement of 129 children at an age of 8-12 years.

    abstract::Status and school achievement of 129 children born in Hessen between 1988 and 1992 and notified by a repeatedly elevated concentration of TSH in neonatal screening were evaluated. Interviews of mothers, teachers and pediatricians were used to score the development and educational achievements, respectively. A total of...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/JPM.2005.097

    authors: Höpfner S,Höpfner B,Rauterberg EW

    更新日期:2005-01-01 00:00:00

  • Long-term epidural block treatment in patients with early threatening preterm delivery and vaginal fetal engagement.

    abstract::We report on an exceptional therapy with epidural anesthesia and tunnelling of the peridural catheter over a time period of 2-14 days in patients with threatening early preterm labor, intact membranes and vaginal engagement of the infants (4 singleton, 8 twin and 2 triplet pregnancies). A combination of bupivacaine (0...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/JPM.2008.081

    authors: Arabin B,Kuizenga K,van Zoeren D,Eyck JV

    更新日期:2008-01-01 00:00:00

  • Events from ovulation to implantation studied by three-dimensional ultrasound.

    abstract::During the last decade transvaginal color Doppler has played an important role in increasing understanding of early human development. Although our knowledge of early pregnancy development has recently improved, little is known about the most critical period of human development: between conception and implantation. R...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,评审

    doi:10.1515/JPM.2002.011

    authors: Kupesić S,Hafner T,Bjelos D

    更新日期:2002-01-01 00:00:00

  • Genome profiles in maternal blood during early onset preeclampsia and towards term.

    abstract:AIMS:inflammatory processes are present during preeclampsia and in normal pregnancy. Maternal inflammatory reactions may change towards term. Our objective was to evaluate genome signaling in blood during preeclampsia and towards term using microarrays. METHODS:RNA microarrays (Illumina) were conducted on blood from p...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm.2010.095

    authors: Dahlstrøm B,Esbensen Y,Vollan H,Oian P,Bukholm G

    更新日期:2010-11-01 00:00:00

  • Starting a regional collaborative research group for COVID-19 in pregnancy: the Southern Michigan experience.

    abstract::The outbreak of the SARS-CoV-2 elicited a surge in publications. Obstetric reports were with few exceptions characterized by small sample sizes with potentially limited generalizability. In this review, evidence suggests increased susceptibility to COVID-19 in pregnancy; common pregnancy comorbidities may help explain...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,评审

    doi:10.1515/jpm-2020-0399

    authors: Bahado-Singh R,Hassan SS,Szymanska M,Sokol RJ

    更新日期:2020-11-26 00:00:00

  • Influence of non-pharmacological obstetric interventions on adverse outcomes of childbirth under regional analgesia.

    abstract::Background We examined the influence of companionship and the use of complementary therapies on adverse outcomes in parturients under regional analgesia. Methods This study is a single-center retrospective cohort of 986 term pregnant women, and it was based on data from medical records (hospitalization period: Novembe...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2019-0366

    authors: Gribel GPC,Coca-Velarde LG,Moreira de Sá RA

    更新日期:2020-06-25 00:00:00

  • A high concentration of fetal fibronectin in cervical secretions increases the risk of intra-amniotic infection and inflammation in patients with preterm labor and intact membranes.

    abstract::Objective To determine whether the risk of intra-amniotic infection/inflammation and spontaneous preterm delivery (SPTD) varies as a function of the concentration of cervical fetal fibronectin (fFN) in patients with preterm labor and intact membranes. Methods This prospective study included 180 patients with preterm l...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2018-0351

    authors: Oh KJ,Romero R,Park JY,Kang J,Hong JS,Yoon BH

    更新日期:2019-04-24 00:00:00

  • Twin fetal facial expressions at 30-33+6 weeks of gestation.

    abstract::Objective To assess the characteristics of twin fetal facial expressions at 30-33 + 6 weeks of gestation using four-dimensional (4D) ultrasound to clarify twin fetal brain development and maturation. Methods Frequencies of seven fetal facial expressions were studied using 4D ultrasound for 15 minutes in 30 singleton p...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2019-0127

    authors: Nitta E,Kanenishi K,Mori N,AboEllail MAM,Hata T

    更新日期:2019-11-26 00:00:00

  • Clinical experience with the triple test for Down's syndrome screening.

    abstract::The introduction of maternal serological screening for chromosome disorders in pregnancy in women aged over 30 years at the estimated date of delivery was monitored in two hospitals. The test used involved measurement of three substances in maternal serum combined with maternal age (the triple test). This is the first...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1991.19.3.151

    authors: Thornton JG,Cartmill RS,Williams J,Holding S,Lilford RJ

    更新日期:1991-01-01 00:00:00

  • Fetal nasal bone length in the second trimester: comparison between population groups from different ethnic origins.

    abstract:OBJECTIVE:To compare normal ranges of ultrasonographically measured fetal nasal bone length in the second trimester between different ethnic groups. METHOD:A prospective, non-interventional study in order to establish normal ranges of fetal nasal bone length in the second trimester in a Greek population was conducted ...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2014-0296

    authors: Papasozomenou P,Athanasiadis AP,Zafrakas M,Panteris E,Loufopoulos A,Assimakopoulos E,Tarlatzis BC

    更新日期:2016-03-01 00:00:00

  • Betamimetics in fetal distress: randomised controlled trial.

    abstract::The objective of the study was to investigate if a single dose of Hexoprenaline administered to patients diagnosed as having fetal distress improves neonatal outcome and whether there are any side effects and complications related to hexoprenaline injection. Patients with fetal distress diagnosed by electronic fetal h...

    journal_title:Journal of perinatal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1515/jpme.1997.25.1.97

    authors: Kulier R,Gülmezoĝlu AM,Hofmeyr GJ,Van Gelderen CJ

    更新日期:1997-01-01 00:00:00

  • Fetal congestive heart failure: correlation of Tei-index and Cardiovascular-score.

    abstract:INTRODUCTION:Congestive heart failure (CHF) may be present in fetuses with hydrops fetalis (HF) and the severity is difficult to quantitate. Differential ventricular dysfunction may be present in the fetus with CHF. A non-geometric measure of ventricular function that is not afterload dependent would be useful to measu...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/JPM.2001.055

    authors: Falkensammer CB,Paul J,Huhta JC

    更新日期:2001-01-01 00:00:00

  • Growth attainment in German children born preterm, and cardiovascular risk factors in adolescence. Analysis of the population representative KiGGS data.

    abstract:AIM:To compare the growth attainment of preterm children and their cardiovascular risk factors at adolescence with the values measured in term children in Germany. METHODS:About 17,641 children aged 0 to <18 years were studied between 2003 and 2006 in the population representative German KiGGS survey ("German Health I...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2016-0294

    authors: Bergmann RL,Bergmann KE,Richter R,Schlaud M,Henrich W,Weichert A

    更新日期:2017-07-26 00:00:00

  • Bronchopulmonary dysplasia and early prophylactic inhaled nitric oxide in preterm infants: current concepts and future research strategies in animal models.

    abstract::We reviewed the literature on the use of inhaled nitric oxide and the influence of supplemental oxygen on bronchopulmonary dysplasia (BPD), and the role of endogenous nitric oxide-synthase, vascular endothelial growth factor, the interplay of nitric oxide and superoxide, protein nitration and the nuclear factor kappa ...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,评审

    doi:10.1515/JPM.2008.065

    authors: Rieger-Fackeldey E,Hentschel R

    更新日期:2008-01-01 00:00:00