Localization and quantification of adhesion molecule expression in the lower uterine segment during premature labor.

Abstract:

AIMS:To investigate localization and concentration of adhesion molecules in the human lower uterine segment during preterm parturition. METHODS:In a prospective study biopsy specimens from the lower uterine segment of 43 patients undergoing cesarean section at 24 + 0 to 36 + 4 weeks' gestation were immunostained for intercellular adhesion molecule-1, endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and platelet endothelial cell adhesion molecule-1, and the concentrations measured by enzyme immunoassay. The results were analyzed in relation to the degree of cervical dilatation (< 2 cm, 2- < 4 cm, > or = 4 cm) and duration of labor (< or = 6 h, > 6-12 h; > 12 h). RESULTS:Intercellular adhesion molecule-1 and platelet endothelial cell adhesion molecule-1 were strongly expressed by capillary endothelium, endothelial leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1 to only a minor degree. Intercellular adhesion molecule-1 concentration was greater at > or = 4 cm dilatation than at 2- < 4 cm and after > 12 h labor than after < or = 6 h. Endothelial leukocyte adhesion molecule-1 concentration was greater after > 12 h than after < or = 6 h. CONCLUSIONS:Premature labor is associated with up-regulation of adhesion molecules in the lower uterine segment.

journal_name

J Perinat Med

authors

Fischer DC,Winkler M,Ruck P,Poth D,Kemp B,Rath W

doi

10.1515/JPM.2001.069

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

497-505

issue

6

eissn

0300-5577

issn

1619-3997

journal_volume

29

pub_type

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