Labour epidural analgesia and anti-infectious management of the neonate: a meta-analysis.

Abstract:

BACKGROUND:A known side effect of labour epidural analgesia (EDA) is maternal fever. It is unclear whether this has effects on the anti-infectious management of the neonate. METHODS:A systematic literature search and a hand search of abstract publications were conducted. Studies reporting sepsis evaluation or antibiotic treatment were further assessed. For meta-analysis, risk ratio (RR) and 95% confidence interval (CI) were calculated using the random effects model. RESULTS:Five relevant articles reporting on 4667 parturients were identified; three were observational studies and two were randomised controlled trials (RCT). The RR for sepsis workup of all studies analysed together was 2.58 (95% CI, 1.06-6.27, P=0.04). The RR for antibiotic treatment of the neonate was 2.76 (95% CI, 1.20-6.31, P=0.02). When considering the RCTs alone, the RRs for sepsis evaluation and antimicrobial treatment were still significantly elevated. DISCUSSION:Our data suggest that EDA-related maternal hyperthermia results in an increased likelihood of sepsis workup and antibiotic treatment of the infant. A crucial question is whether EDA-related maternal hyperthermia is truly infectious. If not, administration of antibiotics would not be justified and may be dangerous.

journal_name

J Perinat Med

authors

Heesen M,Klöhr S,Rossaint R,Straube S,Van de Velde M

doi

10.1515/jpm-2012-0064

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

625-30

issue

6

eissn

0300-5577

issn

1619-3997

pii

/j/jpme.ahead-of-print/jpm-2012-0064/jpm-2012-0064

journal_volume

40

pub_type

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