Abstract:
AIM:The present study attempts to understand the role of methylenetetrahydrofolate reductase C677T (MTHFR C677T) in recurrent pregnancy losses in North Indian women because of hyperhomocysteinemia in light of serum folate and vitamin B₁₂. METHODS:One hundred and seven women with three or more consecutive unexplained recurrent pregnancy losses and 343 women with two or more successful and uncomplicated pregnancies were recruited. Plasma homocysteine, serum folate and vitamin B₁₂ were analyzed using chemiluminescence. MTHFR C677T detection was completed in all subjects. RESULTS:MTHFR genotypic distribution among cases and controls showed no significant difference (P=0.409). However, MTHFR C677T polymorphism was found to be significantly associated with increased homocysteine in the case group (P=0.031). Hyperhomocysteinemia and vitamin B₁₂ deficiency were found to be significant risk factors for recurrent pregnancy loss (RPL) (OR=7.02 and 16.39, respectively). Folate deficiency was more common in controls (63.47%) as compared to the case group (2.56%). CONCLUSION:Low vitamin B₁₂ increases homocysteine, specifically among T allele carrying case mothers, suggesting T allele is detrimental with B₁₂ deficiency. The study emphasizes the importance of vitamin B₁₂ in the prevention of RPL in North Indian women.
journal_name
J Perinat Medjournal_title
Journal of perinatal medicineauthors
Puri M,Kaur L,Walia GK,Mukhopadhhyay R,Sachdeva MP,Trivedi SS,Ghosh PK,Saraswathy KNdoi
10.1515/jpm-2012-0252subject
Has Abstractpub_date
2013-09-01 00:00:00pages
549-54issue
5eissn
0300-5577issn
1619-3997pii
/j/jpme.ahead-of-print/jpm-2012-0252/jpm-2012-0252journal_volume
41pub_type
杂志文章abstract:AIMS:The purpose of this study was to determine whether head circumference (HC) catch-up is associated with improved neurocognitive development. DESIGN:A retrospective cohort study was conducted in 179 preterm very low birth weight (VLBW) (BW≤1500 g) infants. The infants were born in 2000-2002 and were followed to the...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2011.049
更新日期:2011-09-01 00:00:00
abstract::Neonatal and antenatal alloimmune thrombocytopenia is caused by the placental passage of maternal antibodies directed against platelet-specific fetal antigens. This disease is analogous to Rhesus hemolytic disease of the newborn and may be complicated by intracranial hemorrhage. Following increased awareness to the di...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1991.19.6.465
更新日期:1991-01-01 00:00:00
abstract:AIM:To compare oxidative stress in patients with preeclampsia (PE) or intrauterine growth restriction (IUGR) vs. normal pregnancy (controls) during 48 h after delivery. STUDY DESIGN:Women with singleton pregnancies were recruited immediately after delivery (gestational age >26.0 weeks). Women with PE or IUGR were matc...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2008.053
更新日期:2008-01-01 00:00:00
abstract:AIMS:To develop a predictive model for assessing the risk of developing neonatal respiratory morbidity using lamellar body counts (LBCs) and gestational age (GA) to provide a more patient-specific assessment. METHODS:Retrospective cohort study of patients' ≥32 weeks' gestation who received amniocentesis with LBC analy...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2014-0310
更新日期:2016-08-01 00:00:00
abstract::In tocolysis with beta-sympathicomimetics Verapamil is administered universally to reduce the subjective and objective cardiovascular side effects. The efficacy of the calcium-antagonist has not yet been substantiated. This has now re-emerged as an important issue due to the increasing occurrance of cardiopulmonary co...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1981.9.5.235
更新日期:1981-01-01 00:00:00
abstract:UNLABELLED:The objective of this study was the evaluation of intrapartum pulse oximetry as an indicator of fetal distress and the condition of the newborn during clinical routine surveillance in an University Perinatal Center. Between 1998 and 1999 pulse oximetry (SpO2) was used additionally to routine fetal monitoring...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2000.037
更新日期:2000-01-01 00:00:00
abstract::Eighteen women were referred for fetal karyotyping because of advanced maternal age (over 38 years) later than 23 weeks' gestation. In order to obtain more rapid karyotypes, cordocentesis rather than amniocentesis was performed. All procedures were successful, leading to the obtention of normal karyotypes in all cases...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Objective To evaluate the association of a set (or the lack thereof) of pre-gravid maternal features with a better outcome in terms of gestational age and birth weight of twins. Methods Analysis of a Slovenian population-based cohort of all dichorionic twin pairs born at ≥22 weeks during an 11-year period from 2002 to...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2016-0107
更新日期:2017-05-24 00:00:00
abstract::Gross fetal movement was detected using a lower frequency ultrasonic Doppler shift than that used in the study of fetal heart action. The movement signal was changed into deflection which was recorded on CTG chart simultaneously with the fetal heart rate (FHR), and was called the fetal actocardiogram. Visual analysis ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1988.16.4.327
更新日期:1988-01-01 00:00:00
abstract::The blood flow pattern in the common umbilical vein is under normal conditions nonpulsatile in contrast to the flow in the fetal inferior vena cava. We observed pulsatile flow patterns in the common umbilical vein of fetal lambs during changes in the fetal hemodynamic equilibrium. These pulsations may influence the mi...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1986.14.1.19
更新日期:1986-01-01 00:00:00
abstract:AIM:To produce a new scoring system for fetal neurobehavior based on prenatal assessment by 3D/4D sonography. We identified severely brain damaged infants and those with optimal neurological findings and compared fetal with neonatal findings. RESULTS:The new scoring system was retrospectively applied in a group of 100...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2008.007
更新日期:2008-01-01 00:00:00
abstract::The interest in the limit of viability originated from various sources, including legal requirements, the rejection of mechnical life support, competition for resources, concerns about handicaps, and proximity to the fetus with its limited rights. Gestational age was determined from menstrual history by Hippocratic wr...
journal_title:Journal of perinatal medicine
pub_type: 历史文章,杂志文章
doi:10.1515/jpm.2011.056
更新日期:2011-09-01 00:00:00
abstract:AIM:To compare the growth attainment of preterm children and their cardiovascular risk factors at adolescence with the values measured in term children in Germany. METHODS:About 17,641 children aged 0 to <18 years were studied between 2003 and 2006 in the population representative German KiGGS survey ("German Health I...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2016-0294
更新日期:2017-07-26 00:00:00
abstract::To determine if oxytocin dosage used for labor induction differed in obese and lean women, we analyzed records of patients who underwent term labor induction and delivered vaginally. Each of a cohort of 27 patients with a body mass index (BMI) >40 kg/m2 was matched with a patient with a BMI <28 kg/m2 for gestational a...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2014-0134
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to assess, in a population of dichorionic twin pregnancies with selective growth restriction, the effect of inter-twin differences by use of Doppler velocimetry and fetal growth discordancy on perinatal outcomes. METHODS:This was a retrospective study including dichorionic tw...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2017-0253
更新日期:2018-11-27 00:00:00
abstract::Objective To determine whether the risk of intra-amniotic infection/inflammation and spontaneous preterm delivery (SPTD) varies as a function of the concentration of cervical fetal fibronectin (fFN) in patients with preterm labor and intact membranes. Methods This prospective study included 180 patients with preterm l...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2018-0351
更新日期:2019-04-24 00:00:00
abstract:OBJECTIVE:To assess whether maternal multiple sclerosis (MS) is associated with adverse pregnancy outcomes by determining the clinical course of disease during pregnancy and postpartum throughout a 10-year-period in a single tertiary center. METHODS:We conducted a case-control study that included pregnancies with a de...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2016-0060
更新日期:2017-05-24 00:00:00
abstract::The neonatal outcome of 78 consecutive singleton pregnancies complicated by intrauterine growth retardation (IUGR) and gestational hypertension were compared with the outcome of 78 adequately matched pregnancies complicated by idiopathic IUGR. The rate of low (< 5) 1-minute Apgar scores was higher in infants born to h...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1993.21.3.195
更新日期:1993-01-01 00:00:00
abstract::Preterm infants fed fortified human milk (HM) in standard (STD) fashion grow slower than preterm formula fed infants. Recently, low protein intake has been proven to be the primary limiting factor responsible for this growth failure. The main reason of protein undernutrition despite fortification is that STD fortifica...
journal_title:Journal of perinatal medicine
pub_type: 指南,杂志文章
doi:10.1515/jpm.2010.073
更新日期:2010-05-01 00:00:00
abstract:AIMS:To measure plasma concentrations of endothelin (ET)-1, NO metabolites (nitrate/nitrite; NOx) and 6-keto PGF1 alpha (PGF1 alpha) in maternal and fetal sheep blood, and to evaluate the effects of big ET-1 on hemodynamic response, blood gases and NO and 6-keto PGF1 alpha production in near term fetal sheep. METHODS:...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2004.149
更新日期:2004-01-01 00:00:00
abstract::Teratomas are tumors containing tissues derived from all three germinal cell layers. Most teratomas arise in the sacrococcygeal region, with a reported incidence of 1/40,000 births. During labor, severe dystocia may occur in infants with large tumors if delivered vaginally, with an extremely high fetal morbidity and m...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1989.17.2.93
更新日期:1989-01-01 00:00:00
abstract:AIMS:Psychosocial stress during pregnancy (PSP) is a risk factor of growing interest in the etiology of preterm birth (PTB). This literature review assesses the published evidence concerning the association between PSP and PTB, highlighting established and hypothesized physiological pathways mediating this association....
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpm-2012-0295
更新日期:2013-11-01 00:00:00
abstract::Background Thyroid cancer is one of the most common cancers in women of reproductive age. Our purpose was to evaluate the association between thyroid cancer and maternal and neonatal outcomes of pregnancy. Methods We conducted a retrospective cohort study using the Healthcare Cost and Utilization Project, Nationwide I...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2019-0039
更新日期:2019-09-25 00:00:00
abstract::A survey of the clinical records of fifteen fetuses with trisomy 21, six fetuses with trisomy 18, and two fetuses with trisomy 13 was made in order to find out typical patterns of fetal heart rate (FHR) possibly associated with these conditions. Antepartal FHR patterns of 55 normal pregnancies and intrapartal FHR patt...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1982.10.5.242
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVE:To assess mid-trimester amniotic fluid concentrations of interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, and lipopolysaccharide binding protein (LBP) in pregnancies with normal outcome and correlate them with gestational week (GW), parity, and fetal gender. METHODS:Cytokine concentrations were measu...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2011.041
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To identify risk factors among children with unknown cause intellectual disability (ID) and to estimate the population-attributable risk (PAR) associated with these factors. METHODS:This was a retrospective cohort study of maternal and child pairs born between 2004 and 2010 in South Carolina, and information...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2015-0059
更新日期:2016-05-01 00:00:00
abstract:AIM:To compare smooth muscle cells, type I collagen, and apoptosis of the lower uterine segment of women who had/without a prior cesarean delivery. METHODS:Alpha smooth muscle actin (α-SMA), type I collagen, and nuclear apoptosis were compared between the groups from lower uterine segment. Twenty-eight controls and 82...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2016-0347
更新日期:2018-05-24 00:00:00
abstract:OBJECTIVE:Parents of preterm infants require information on morbidity and duration of common interventions performed in the NICU. Since locally achieved data are often not available, information is mainly based on educated guesses of health care professionals. The present study compares estimates of neonatal nurses or ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,多中心研究
doi:10.1515/JPM.2007.074
更新日期:2007-01-01 00:00:00
abstract::Monitoring of spontaneous brain electrical activity (EEG) has three purposes: Detecting sudden loss of background activity as an early sign of brain hypoxia/ischaemia, detection of silent seizures, and helping to diagnose brain damage. Tape-recording allows storage of upto 8 channels of standard EEG for prolonged peri...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:To examine the proportion of iatrogenic births among all preterm births over a 26-year period. PATIENTS AND METHODS:A registry-based survey of preterm deliveries between 1987 and 2012 analyzed by the onset of labor: spontaneous with intact membranes, preterm premature rupture of membranes (PPROM) or iatrogen...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2015-0271
更新日期:2016-07-01 00:00:00