A preliminary study of uterine scar tissue following cesarean section.

Abstract:

AIM:To compare smooth muscle cells, type I collagen, and apoptosis of the lower uterine segment of women who had/without a prior cesarean delivery. METHODS:Alpha smooth muscle actin (α-SMA), type I collagen, and nuclear apoptosis were compared between the groups from lower uterine segment. Twenty-eight controls and 82 with one prior cesarean delivery were included. The women with a prior cesarean section were classified by time since the surgery: ≤3 years, >3 and ≤5 years, >5 and ≤7 years, >7 and ≤9 years, and >9 years. RESULTS:Smooth muscle volume density (VD) % was significantly lower in women who had cesarean sections in first three groups than in the controls (all, P<0.01). Type I collagen VD% was similar among all groups and the controls. The number of apoptotic nuclei in the lower uterine segment of the scarred group was greater up to 3 years after surgery and less than in the control at 7-9 years. The number of non-apoptotic nuclei in the scarred group was greater than controls up to 7 years after surgery. CONCLUSION:The lower uterine segment scar becomes stable at 3 years after cesarean delivery, and by 9 years, the scar is mature.

journal_name

J Perinat Med

authors

Wu C,Chen X,Mei Z,Zhou J,Wu L,Chiu WH,Xiao X

doi

10.1515/jpm-2016-0347

subject

Has Abstract

pub_date

2018-05-24 00:00:00

pages

379-386

issue

4

eissn

0300-5577

issn

1619-3997

pii

/j/jpme.ahead-of-print/jpm-2016-0347/jpm-2016-0347

journal_volume

46

pub_type

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