Abstract:
:The placenta is the principal organ regulating respiratory, nutritional, endocrine and metabolic functions on behalf of the developing fetus. Changes in gene expression patterns of placenta-specific genes may influence fetal growth. We profiled the expression of 17 genes related to placenta functioning in term placentas (n=677) to identify genes differentially expressed across birth weight categories [small (SGA), appropriate (AGA) and large (LGA) for gestational age]. ABCG2, CEBPB, CRH, GCM1, GPC3, INSL4, PGF and PLAC1 were inversely associated with LGA status, with odds ratios (ORs) and 95% confidence intervals (CI) ranging from GCM1 (OR=0.44, 95% CI: 0.29, 0.70) to CRH (OR=0.73, 95% CI: 0.61, 0.88). NR3C1 was positively associated with LGA status (OR=2.33, 95% CI: 1.43, 3.78). PLAC1 (OR=0.66, 95% CI: 0.47, 0.92) and ABCG2 (OR=0.63, 95% CI: 0.44, 0.91) were additionally inversely associated with SGA status, and PGF was positively associated with SGA status (OR=1.59, 95% CI=1.08, 2.35). General trends were confirmed in an independent cohort (n=306). Given that aberrant fetal growth may have long-lasting effects, our results suggest the potential utility of placental gene expression profiles as potential early markers of disease onset later in life.
journal_name
J Perinat Medjournal_title
Journal of perinatal medicineauthors
Deyssenroth MA,Li Q,Lacasaña M,Nomura Y,Marsit C,Chen Jdoi
10.1515/jpm-2017-0064subject
Has Abstractpub_date
2017-10-26 00:00:00pages
887-893issue
7eissn
0300-5577issn
1619-3997pii
/j/jpme.ahead-of-print/jpm-2017-0064/jpm-2017-0064journal_volume
45pub_type
杂志文章abstract::Many decisions in pregnancy are based on one or two casual blood pressure estimations made in the antenatal clinic. No previous study has challenged the validity of this practice or attempted to discover whether there are significant differences between the blood pressures of pregnant women when they are measured in t...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1991.19.1-2.133
更新日期:1991-01-01 00:00:00
abstract::Although premature infants are increasingly surviving the neonatal period, up to one-third develop bronchopulmonary dysplasia (BPD). Despite evidence that bacterial colonization of the neonatal respiratory tract by certain bacteria may be a risk factor in BPD development, little is known about the role these bacteria ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2010.026
更新日期:2010-05-01 00:00:00
abstract::Objectives Recombinant human erythropoietin (rhEPO) has been shown to effectively and safely prevent the anemia of prematurity and to reduce the transfusion need in very low birth weight (VLBW) infants and has been licensed for this indication in Europe in 1997. The objective of the study was to obtain information on ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2020-0070
更新日期:2020-09-25 00:00:00
abstract::Postpartum hemorrhage is a continuing problem occurring in 5-10% of all deliveries. Due to recent problems with blood transfusion, heterologous blood is nowadays restricted to life-threatening indications. As a consequence the clinician is faced with many patients suffering from overt symptoms of anemia. We therefore ...
journal_title:Journal of perinatal medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1515/jpme.1995.23.1-2.111
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To examine the impact of maternal obesity on completion of fetal anomaly screening. METHODS:A retrospective analysis of 500 anomaly scans (19+0-21+6 weeks) was included. Women were categorised according to the World Health Organisation (WHO) body mass index (BMI) classification: normal weight (18.50-24.99 kg...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2016-0048
更新日期:2017-12-20 00:00:00
abstract::The development of assisted reproduction techniques (ART) represents an important advance in the treatment of human infertility. However, their great effectiveness has brought with it an excessive increase in multiple pregnancy rates with the serious medical, financial and social consequences that they entail. Now, th...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpm.2011.020
更新日期:2011-05-01 00:00:00
abstract::Erythrocyte deformability is an important determinant of microcirculation, of oxygen transport and release to the tissue. In an attempt to clarify the rheological peculiarity during pregnancy, erythrocyte deformability was measured in 10 nonpregnant controls and 10 pairs of mothers and newborns. When the hematocrit of...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1995.23.4.301
更新日期:1995-01-01 00:00:00
abstract:AIM:Evaluate the relationship between neonatal weight and pregnancy-associated plasma protein-A. METHODS:Retrospective study on 2564 singleton pregnancies with healthy term neonates in three groups of women with different values of pregnancy-associated plasma protein-A who underwent the combined test during the first ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2013-0249
更新日期:2015-03-01 00:00:00
abstract::Rescue cervical cerclage (RCC), also known as emergency cerclage, has long been the subject of controversy. Its use in women who have a dilated cervix has been ambivalent. RCC is often considered as a salvage measure for pregnancies which are at a high risk of severe preterm delivery (PTD) or mid-trimester miscarriage...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2017-0311
更新日期:2018-10-25 00:00:00
abstract::A new design of vacuum extractor cup--'the New Generation cup'--has recently been introduced into clinical practice. Its major modification is a traction cord which passes around the rim of the cup for 180 degrees and is free to slide within the rim. Claims that this design 'enables the operator to pull obliquely with...
journal_title:Journal of perinatal medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1515/jpme.1986.14.2.95
更新日期:1986-01-01 00:00:00
abstract:AIM:The aim of this study was to assess the risk of subsequent delivery complications after extremely preterm deliveries by initial (index) pregnancy mode of delivery (MOD): cesarean (CD) versus vaginal (VD). METHODS:This is a retrospective, longitudinal cohort study using Washington State birth certificate data and I...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2013-0023
更新日期:2013-11-01 00:00:00
abstract::Listeria is commonly found in processed and prepared foods and listeriosis is associated with high morbidity and mortality. Preventative measures are well prescribed and monitoring and voluntary recall of contaminated products has resulted in a 44% reduction in the prevalence of perinatal listeriosis in the USA. Pregn...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpm.2011.035
更新日期:2011-05-01 00:00:00
abstract::Single dose pharmacokinetics of 75 mg aspirin was investigated in two groups of ten women with clinically normal pregnancies. Eleven non-pregnant subjects in the same age were controls. In group A, gestational age was 27-30 completed weeks, and in group B, 36-39 weeks. Venous blood samples were taken before and up to ...
journal_title:Journal of perinatal medicine
pub_type: 临床试验,杂志文章
doi:10.1515/jpme.1994.22.3.205
更新日期:1994-01-01 00:00:00
abstract::The concentration of bupivacaine in organs of non-viable human fetuses after obstetrical epidural analgesia in customary doses was investigated. The concentrations were determined with a gas chromatograph. The material consisted of a fetus who died following termination in the 24th week of pregnancy three minutes afte...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1986.14.4.219
更新日期:1986-01-01 00:00:00
abstract:AIM:Previous data from our Kaulsdorf Cohort Study (KCS) suggest that early neonatal ingestion (1st week) of breast milk from diabetic mothers (diabetic breast milk, DBM) may increase the risk of being overweight and delay speech development in offspring of diabetic mothers (ODM). Late neonatal DBM ingestion (2nd-4th we...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2006.095
更新日期:2006-01-01 00:00:00
abstract::Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder of pregnancy. Diagnosis is based on the clinical picture, particularly the presence of pruritus with a deterioration of liver function tests, and typically elevated serum levels of total bile acids. ICP manifests in the second half of pregna...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpm-2014-0089
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect on perinatal outcome of replacing glucose measurements for the diagnosis of gestational diabetes mellitus in central laboratories with those obtained by portable glucose meter. STUDY DESIGN:Simultaneously, venous blood samples were taken at the 100-g glucose tolerance test, and finger ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2003.019
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To compare the incidence of twin births and their birth weight characteristics in mothers aged > or = 40 years with those of mothers aged 35-39 years. METHODS:We used a population-based cohort of Israeli twins delivered between 1993-98 to compare birth weight characteristics of 510 and 2102 twin pairs delive...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2001.016
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To assess whether maternal multiple sclerosis (MS) is associated with adverse pregnancy outcomes by determining the clinical course of disease during pregnancy and postpartum throughout a 10-year-period in a single tertiary center. METHODS:We conducted a case-control study that included pregnancies with a de...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2016-0060
更新日期:2017-05-24 00:00:00
abstract:AIMS:The number of fetuses with an abnormal increased first trimester nuchal translucency (NT), but confirmed normal karyotype and anatomy is relatively small and therefore a challenge for prenatal counseling. Universal guidelines are still needed for a systematic work-up, how to decide on the rewarding cut-off for thi...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/JPM.2005.036
更新日期:2005-01-01 00:00:00
abstract::The purpose of this paper was to describe whether there are some relationships between amikacin serum levels and central conduction time in brainstem auditory evoked potentials (BAEP) within therapeutic range levels in newborns as index of drug toxicity in brainstem auditory centers in neonatally exposed infants. We p...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2003.032
更新日期:2003-01-01 00:00:00
abstract::A patient was admitted to the hospital in the 31st week of gestation because of reduced sensation of fetal movements and a pathologic fetal heart rate tracing (Fig. 1). At first no underlying pathology could be found. After a week she developed a polyhydramnios. After repeated ultrasonographic examinations an atresia ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1984.12.6.325
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:To study maternal lipoprotein(a) levels in normal pregnancy and in pregnancy with evidence of vascular disease in the maternal uteroplacental circulation defined by Doppler ultrasound study. SAMPLES:Maternal venous blood was collected from 75 normal pregnant women and 68 pregnant women with evidence of poten...
journal_title:Journal of perinatal medicine
pub_type: 临床试验,杂志文章
doi:10.1515/JPM.2003.003
更新日期:2003-01-01 00:00:00
abstract::In 29 cases of vaginal delivery with normal outcome and 4 cases of cesarean section, the concentrations of beta-endorphin, ACTH and cortisol were determined in maternal venous and umbilical venous plasma immediately postpartum. According to duration of labor and mode of delivery the cases examined were classified into...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1987.15.1.45
更新日期:1987-01-01 00:00:00
abstract::The excretion of ketobemidone into human breast milk was investigated in three women who obtained ketobemidone as postoperative pain relief after Cesarean section and two women premedicated with 5 mg of ketobemidone before currettage after delivery. The highest observed concentration of ketobemidone in breast milk was...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1996.24.3.293
更新日期:1996-01-01 00:00:00
abstract::In order to search for any difference in riboflavin and pyridoxine nutrition between term appropriate for gestational age (TAGA), term small for gestational age (TSGA) and preterm appropriate for gestational age (PTAGA) newborns, cord blood from 23, 19 and 20 infants, respectively, were studied, and red cell glutathio...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1996.24.3.221
更新日期:1996-01-01 00:00:00
abstract::Upper gastrointestinal contrast studies are frequently performed in neonates to rule out conditions such as malrotation. Low osmolality water-soluble (LOWS) contrast media are currently considered safe for use in neonates. The clinical course of a neonate with suspected necrotising enterocolitis, who deteriorated sign...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2003.080
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:The 2nd born in twin delivery is at higher risk of fetal asphyxia. We tested the hypothesis that inadequate, fetal heart rate (FHR) monitoring has contributed to an inadvertent outcome. STUDY DESIGN:A database was reviewed consisting of 41 twin deliveries with a pH in the umbilical artery of the 2nd twin be...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2009.015
更新日期:2009-01-01 00:00:00
abstract::The objective of this study was to analyse the relation between severity of maternal condition at the time of intensive care unit (ICU) admission and various individual and institutional factors. This study analysed data from a retrospective population-based study in three French regions during 1991. The population st...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1998.26.5.354
更新日期:1998-01-01 00:00:00
abstract::Objective To investigate the correlation between aneuploidy pregnancy and the concentration of various hormones and vascular endothelial factor in follicular fluid as well as the number of acquired oocytes and to provide a scientific basis for improving ovulation induction programs. Methods In total, we collected 277 ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2019-0377
更新日期:2019-12-18 00:00:00