Abstract：
:The concentration of bupivacaine in organs of non-viable human fetuses after obstetrical epidural analgesia in customary doses was investigated. The concentrations were determined with a gas chromatograph. The material consisted of a fetus who died following termination in the 24th week of pregnancy three minutes after birth without spontaneous respiration. The other fetus was born maturely in the 40th pregnancy week with anencephaly who lived 20 minutes following initial spontaneous respiration. Most noteworthy were the increased concentrations in the liver indicating the important metabolic function of the liver for the metabolism of bupivacaine in the fetus. Further a very high pulmonary concentration was found in the mature fetus. Even though blood gases analysis were not performed we conclude that: the lung is the best perfused organ after birth and onset of spontaneous respiration because of the closure of the ductus arteriosus; because of the increasing agonal respiratory acidosis, bupivacaine accumulates in the lung, the organ from which the acidosis originates. Also, the ionized form the bupivacaine is unable to leave the intracellular space. For the clinical use of epidural analgesia during delivery, these results constitute an important indication for avoiding fetal acidosis before and during the action of such analgesia. This mandates strict and continuous fetal monitoring. Our results in agreement with other authors show that during fetal acidosis and simultaneous administration of bupivacaine the fetal distress may be potentiated by an accelerated transfer of the anesthetic agent into the fetal placental space. Under normal conditions one may assume that this technique of analgesia has a positive effect on the fetus because of the improved placental perfusion.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Perinat Medjournal_title
Journal of perinatal medicineauthors
Müller-Holve W,von Meyer L,Nagler Pdoi
10.1515/jpme.1986.14.4.219subject
Has Abstractpub_date
1986-01-01 00:00:00pages
219-25issue
4eissn
0300-5577issn
1619-3997journal_volume
14pub_type
杂志文章abstract：:Preterm infants fed fortified human milk (HM) in standard (STD) fashion grow slower than preterm formula fed infants. Recently, low protein intake has been proven to be the primary limiting factor responsible for this growth failure. The main reason of protein undernutrition despite fortification is that STD fortifica...
journal_title：Journal of perinatal medicine
pub_type： 指南,杂志文章
doi：10.1515/jpm.2010.073
更新日期：2010-05-01 00:00:00
abstract：:Objective To investigate the correlation between aneuploidy pregnancy and the concentration of various hormones and vascular endothelial factor in follicular fluid as well as the number of acquired oocytes and to provide a scientific basis for improving ovulation induction programs. Methods In total, we collected 277 ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm-2019-0377
更新日期：2019-12-18 00:00:00
abstract：:Dextrostix is now widely used as a method of screening for hypoglycemia of the newborn. There has always been some anxiety about its accuracy for estimating very low blood sugars; this is important, since symptomatic hypoglycemia of the newborn does not usually occur until the blood glucose falls below 20 mg/dl. In 19...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1976.4.2.106
更新日期：1976-01-01 00:00:00
abstract：:Various substances and methods are used as alternatives to corticoids for stimulating antenatal pulmonary maturation. This study discusses thyroid hormones, intralipid, ambroxol, carnitine, theophylline (aminophylline) and betasympathomimetic agents. ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1987.15.5.453
更新日期：1987-01-01 00:00:00
abstract：:A patient was admitted to the hospital in the 31st week of gestation because of reduced sensation of fetal movements and a pathologic fetal heart rate tracing (Fig. 1). At first no underlying pathology could be found. After a week she developed a polyhydramnios. After repeated ultrasonographic examinations an atresia ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1984.12.6.325
更新日期：1984-01-01 00:00:00
abstract：:Universally 4 million newborns die and another 4 million are stillborn every year. 98% of these neonatal deaths take place in the developing countries. Looking at the state of the world's newborns one can see that neonatal mortality rate is about 4-5 per 1000 in the developed countries and nearly 10 fold this in the d...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章,评审
doi：10.1515/JPM.2003.060
更新日期：2003-01-01 00:00:00
abstract：:The aim of this experimental ultrasound study on six fetal lambs was to evaluate how blood flow variables and vessel diameters of the descending aorta and the common carotid artery change during fetal asphyxia in the acute preparation. When acute asphyxia was induced by obstructing the maternal aortic blood flow all f...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:We report on an exceptional therapy with epidural anesthesia and tunnelling of the peridural catheter over a time period of 2-14 days in patients with threatening early preterm labor, intact membranes and vaginal engagement of the infants (4 singleton, 8 twin and 2 triplet pregnancies). A combination of bupivacaine (0...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.2008.081
更新日期：2008-01-01 00:00:00
abstract：AIMS:To investigate localization and concentration of adhesion molecules in the human lower uterine segment during preterm parturition. METHODS:In a prospective study biopsy specimens from the lower uterine segment of 43 patients undergoing cesarean section at 24 + 0 to 36 + 4 weeks' gestation were immunostained for i...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.2001.069
更新日期：2001-01-01 00:00:00
abstract：:For the higher numbered multifetal gestation, duration of gestational age decreases in spite of different medical activities. On the other hand increasing gestational age often strongly suggests the need for delivery by caesarean section for maternal indications. After the 32nd week of gestation in general no serious ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1993.21.4.295
更新日期：1993-01-01 00:00:00
abstract：:Objective To assess the characteristics of twin fetal facial expressions at 30-33 + 6 weeks of gestation using four-dimensional (4D) ultrasound to clarify twin fetal brain development and maturation. Methods Frequencies of seven fetal facial expressions were studied using 4D ultrasound for 15 minutes in 30 singleton p...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm-2019-0127
更新日期：2019-11-26 00:00:00
abstract：:Our purpose was to evaluate the hemodynamic significance of fetal inferior vena cava (IVC) flow velocity waveform indices during fetal development in relation to the diameter pulse waveform. Doppler ultrasound and a phase locked loop echo tracking system were used to measure flow velocity waveform and diameter pulse w...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.2006.082
更新日期：2006-01-01 00:00:00
abstract：:The aim of the study was to compare gradients of skin surface temperature on the arm and hand and to evaluate differences in the skin microcirculation reactivity between pregnant and non-pregnant women. We used the prototype of a highly sensitive thermograph system for the measurements. Eight healthy, non-pregnant wom...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1990.18.5.383
更新日期：1990-01-01 00:00:00
abstract：:The blood flow pattern in the common umbilical vein is under normal conditions nonpulsatile in contrast to the flow in the fetal inferior vena cava. We observed pulsatile flow patterns in the common umbilical vein of fetal lambs during changes in the fetal hemodynamic equilibrium. These pulsations may influence the mi...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1986.14.1.19
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVES:to assess the relationship between maternal and umbilical serum concentrations of matrix metalloproteinases (MMP)-2,8,9, the soluble receptor for advanced glycation end products (sRAGE) and IL-10 and premature delivery and fetal inflammation. METHODS:maternal serum levels of MMPs, sRAGE, IL-10 and C-reactiv...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm.2010.092
更新日期：2010-11-01 00:00:00
abstract：:During pregnancy the role of the cervix shifts between two opposing functions. Throughout most of gestation, the cervix is rigid and resists tension in order to maintain the products of conception inside the uterus. At term, however, cervical function changes drastically in order to accommodate stretch and delivery. T...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.1999.026
更新日期：1999-01-01 00:00:00
abstract：AIMS:The present longitudinal study sought to explore the relationship between parental grief following perinatal bereavement and subsequent pregnancy, according to the particular facets of grief and pregnancy state being considered. METHOD:The study participants were 63 couples who had been bereaved by stillbirth (n ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.2006.036
更新日期：2006-01-01 00:00:00
abstract：:Status and school achievement of 129 children born in Hessen between 1988 and 1992 and notified by a repeatedly elevated concentration of TSH in neonatal screening were evaluated. Interviews of mothers, teachers and pediatricians were used to score the development and educational achievements, respectively. A total of...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.2005.097
更新日期：2005-01-01 00:00:00
abstract：:Maternal nutrition may be one of the most important under-evaluated factors contributing to the contemporary rise in prematurity in the United States and other industrialized nations around the world. Slowed fetal growth has been repeatedly shown to be associated with preterm birth, in both singleton and twin pregnanc...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章,评审
doi：10.1515/JPM.2005.088
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVE:To determine the effects of Betamethasone injections on maternal white blood cell counts. STUDY DESIGN:Thirteen pregnant women without fever or clinical infection and with premature rupture of the membranes at less than 34 weeks gestation were studied. No subject had labor during the week of study. Daily com...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1998.26.3.204
更新日期：1998-01-01 00:00:00
abstract：:The renin-angiotensin system and dietary sodium have been repeatedly implicated in the pathogenesis of pregnancy induced hypertension (PIH). Mechanisms responsible for increased vascular responsiveness to angiotensin II (A-II) observed in PIH are not completely understood. Plasma A-II levels and blood pressure are fun...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1984.12.4.167
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVE:To determine pregnancy outcome in patients with short cervix on transvaginal ultrasound between 16 and 24 weeks' gestation treated with McDonald cerclage compared to weekly intramuscular injections of 17 alpha-hydroxyprogesterone caproate (17OHP-C). METHODS:From November 2003 through December 2006, asymptoma...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章,随机对照试验
doi：10.1515/JPM.2009.083
更新日期：2009-01-01 00:00:00
abstract：:Upper gastrointestinal contrast studies are frequently performed in neonates to rule out conditions such as malrotation. Low osmolality water-soluble (LOWS) contrast media are currently considered safe for use in neonates. The clinical course of a neonate with suspected necrotising enterocolitis, who deteriorated sign...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.2003.080
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:To construct an ultrasonographic nomogram of the fetal gastric size with gestational age in normal singleton pregnancy. PATIENTS AND METHODS:Out of 17 000 outpatient pregnant women who were admitted to our hospital, a total of 250 fetal measurements were randomly collected from routine ultrasonographic exami...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/JPM.2005.060
更新日期：2005-01-01 00:00:00
abstract：:Objective To explore whether the average price of houses per postcode sector [sector house average prices (SHAP)] is related to perinatal outcomes and whether gestational age would be lower and mortality higher in the least expensive areas compared to the most expensive. Methods All neonatal unit admissions at King's ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm-2017-0397
更新日期：2018-12-19 00:00:00
abstract：OBJECTIVE:To determine the incidence, clinical significance and causes of maternal thrombocytopenia in triplet gestations. STUDY DESIGN:The study population consisted of 150 patients with triplet gestation that delivered at our department between 1990 and 2008. Thrombocytopenia was defined as a platelet count <150,000...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpm.2011.123
更新日期：2012-01-06 00:00:00
abstract：:The transcutaneous PO2 (tcPO2) response to blood interruption (BIS test) was measured in 6 healthy adults and 28 infants, including premature infants. The response was similar in both infants and adults with a time lag at the beginning of blood interruption, a subsequent linear decrease, a time lag at the end of blood...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：10.1515/jpme.1992.20.5.371
更新日期：1992-01-01 00:00:00
abstract：:Listeria is commonly found in processed and prepared foods and listeriosis is associated with high morbidity and mortality. Preventative measures are well prescribed and monitoring and voluntary recall of contaminated products has resulted in a 44% reduction in the prevalence of perinatal listeriosis in the USA. Pregn...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章,评审
doi：10.1515/jpm.2011.035
更新日期：2011-05-01 00:00:00
abstract：:Eighteen women were referred for fetal karyotyping because of advanced maternal age (over 38 years) later than 23 weeks' gestation. In order to obtain more rapid karyotypes, cordocentesis rather than amniocentesis was performed. All procedures were successful, leading to the obtention of normal karyotypes in all cases...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Results from randomised trials with formal randomisation indicate no evidence of benefits in terms of cesarean delivery of maternal/neonatal infectious morbidity by awaiting spontaneous onset of labor for more than 24 hours in women with term PROM. An overnight policy of management seems to be an attractive alternativ...
journal_title：Journal of perinatal medicine
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
