Fetal complications due to intrahepatic cholestasis of pregnancy.

Abstract:

:Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder of pregnancy. Diagnosis is based on the clinical picture, particularly the presence of pruritus with a deterioration of liver function tests, and typically elevated serum levels of total bile acids. ICP manifests in the second half of pregnancy, predominantly during the third trimester. Symptoms of the disease resolve spontaneously after delivery. Etiology is still not fully understood. Genetic defects in specific transport proteins, elevated levels of sex hormones, and various environmental factors are thought to play a role in the development of this disorder. Although practically benign for the pregnant woman, ICP represents a serious threat to the fetus. It increases the risk of preterm delivery, meconium excretion into the amniotic fluid, respiratory distress syndrome, and sudden intrauterine fetal death. Identifying fetuses at risk of ICP complications remains challenging. The ideal obstetrical management of ICP needs to be definitively determined. The aim of this review is to summarize the current knowledge on fetal complications of ICP and describe management options for their prevention.

journal_name

J Perinat Med

authors

Šimják P,Pařízek A,Vítek L,Černý A,Adamcová K,Koucký M,Hill M,Dušková M,Stárka L

doi

10.1515/jpm-2014-0089

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

133-9

issue

2

eissn

0300-5577

issn

1619-3997

pii

/j/jpme.ahead-of-print/jpm-2014-0089/jpm-2014-0089

journal_volume

43

pub_type

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