Abstract:
OBJECTIVE:Placement of a cervical cerclage at mid-trimester in women at risk for preterm labor is a common procedure with apparent benefits for some women. However, the changes that occur in the cervix following this procedure remain incompletely identified. METHODS:We evaluated the endocervical concentrations of mediators involved in extracellular matrix (ECM) stabilization or degradation prior to, and up to 120 days following, cerclage placement in 53 women who underwent an ultrasound-indicated or a rescue cerclage at 15-25 weeks of gestation due to a cervical length <1.5 cm. All delivered a healthy neonate at term. Samples were tested by enzyme-linked immunosorbent assay for concentrations of hyaluronan (HA), 27 kDa heat shock protein (hsp27), transforming growth factor-β (TGF-β), extracellular matrix metalloproteinase inducer (CD147/EMMPRIN), and matrix metalloproteinase (MMP)-1 and -8. RESULTS:Concentrations of both HA and hsp27 were highest at the time of cerclage placement and then decreased while TGF-β and EMMPRIN increased in concentration following the procedure. The highest mean EMMPRIN level was measured at >90 days following the procedure while TGF-β levels peaked at 61-90 days post-cerclage. MMP-1 and MMP-8 were not detected over the study time period. CONCLUSION:In women with a successful cerclage placement the selective regulation of mediators inhibits progression of ECM degradation and cervical ripening.
journal_name
J Perinat Medjournal_title
Journal of perinatal medicineauthors
Kanninen TT,Herway C,Skupski DW,Eglinton GS,Witkin SSdoi
10.1515/JPM.2011.132subject
Has Abstractpub_date
2011-11-25 00:00:00pages
159-63issue
2eissn
0300-5577issn
1619-3997pii
/j/jpme.2012.40.issue-2/jpm.2011.132/jpm.2011.132.journal_volume
40pub_type
杂志文章abstract:OBJECTIVE:To assess longitudinally the changes in cervical volume and vascularization during the peripartum period using three-dimensional ultrasound (3D US) and power Doppler and to determine whether these measures change with gestational complications. METHODS:Longitudinal measurements of cervical dimensions by tran...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2010.087
更新日期:2010-09-01 00:00:00
abstract::Plasma lipoprotein, cholesterol and triglycerides were determined in 34 hypertensive pregnant patients and in 17 healthy full term pregnant women. Pregnancy induced hypertension was diagnosed in 21 patients and chronic hypertension in the remaining 13 women. Serum triglyceride levels were significantly elevated in the...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1990.18.6.473
更新日期:1990-01-01 00:00:00
abstract:OBJECT:To assess whether transvaginal ultrasound is helpful in predicting the post-term onset of labor (> or = 1 weeks). SETTING:Antenatal clinic of a University hospital and referral center. SUBJECT AND MEHODS: One hundred and twenty singleton uncomplicated pregnancies in primiparous women were enrolled at 37 weeks o...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2001.045
更新日期:2001-01-01 00:00:00
abstract::Results from randomised trials with formal randomisation indicate no evidence of benefits in terms of cesarean delivery of maternal/neonatal infectious morbidity by awaiting spontaneous onset of labor for more than 24 hours in women with term PROM. An overnight policy of management seems to be an attractive alternativ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract::Objective To derive and validate a population-specific multivariate approach for birth weight (BW) prediction based on quantitative intrapartum assessment of maternal characteristics by means of an algorithmic method in low-risk women. Methods The derivation part (n = 200) prospectively explored 10 variables to create...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2018-0347
更新日期:2019-08-27 00:00:00
abstract::The influence of perinatal asphyxia in the secretion of atrial natriuretic factor (ANF) during the first 6 days of life, and its renal consequences are discussed. Comparison between 20 healthy term neonates and 19 with first--or second--degree hypoxic-ischemic encephalopathy (HIE) is made. Daily controls were performe...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:AIM:P-selectin is a member of selectin family (E, L- and P-selectins) which plays a crucial role in reproduction and hemostasis as well as in pathogenesis of preeclampsia. There are no regular studies on P-selectin in placenta and it is not clear whether it is present in gestational myometrium. In the present study, we...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2008.037
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect on perinatal outcome of replacing glucose measurements for the diagnosis of gestational diabetes mellitus in central laboratories with those obtained by portable glucose meter. STUDY DESIGN:Simultaneously, venous blood samples were taken at the 100-g glucose tolerance test, and finger ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2003.019
更新日期:2003-01-01 00:00:00
abstract::During the past decade a variety of intrapartum fetal monitors have been constructed that process the entire fetal electrocardiogram (FECG), obtained via a scalp electrode. They therefore differ from conventional monitors in aiming to extract relevant timing and magnitude information from the morphology of the FECG ra...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpme.1996.24.1.43
更新日期:1996-01-01 00:00:00
abstract::In preterm infants, feeding with human milk (HM) is a very effective intervention for the prevention of infections and necrotizing enterocolitis (NEC), and for potentially improved neurocognitive and cardiovascular outcomes in the long-term. Hospitals and physicians are advised to recommend HM for preterm and other hi...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,实务指引
doi:10.1515/jpm.2010.064
更新日期:2010-07-01 00:00:00
abstract:AIMS:To measure plasma concentrations of endothelin (ET)-1, NO metabolites (nitrate/nitrite; NOx) and 6-keto PGF1 alpha (PGF1 alpha) in maternal and fetal sheep blood, and to evaluate the effects of big ET-1 on hemodynamic response, blood gases and NO and 6-keto PGF1 alpha production in near term fetal sheep. METHODS:...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2004.149
更新日期:2004-01-01 00:00:00
abstract:AIMS:The number of fetuses with an abnormal increased first trimester nuchal translucency (NT), but confirmed normal karyotype and anatomy is relatively small and therefore a challenge for prenatal counseling. Universal guidelines are still needed for a systematic work-up, how to decide on the rewarding cut-off for thi...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/JPM.2005.036
更新日期:2005-01-01 00:00:00
abstract::A fatality from a tracheoesophageal fistula (TEF) in two extremely low birth weight infants is presented. The sudden onset of intractable respiratory failure accompanied by the absence of chest movement and breathing sounds was observed. The typical clinical symptoms were concealed because the infants required mechani...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2002.037
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:This prospective observational study evaluated maternal symptoms and characteristics that predict successful labor induction with oral misoprostol. METHODS:A total of 244 consecutive women undergoing labor induction voluntarily completed a questionnaire about subjective sensations and pain scores during the ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2011.032
更新日期:2011-05-01 00:00:00
abstract::Serum calcium and 25-OH-D3 in mothers of newborns with craniotabes. The aim of this study was to investigate whether calcium or vitamin D balance during late pregnancy have influence on the outcome of newborn craniotabes. 27 mothers and their fullterm newborns with craniotabes in two series were studied for clinical f...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1983.11.2.127
更新日期:1983-01-01 00:00:00
abstract::The aim of this paper is to establish the exact incidence of risk in delivery as related to perinatal mortality rate. The entire 1976 Italian population was statistically sampled (latest data available), specifically enucleating the sanitary data reported in 1976 by ISTAT (National Institute of Statistics) for the var...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1982.10.6.293
更新日期:1982-01-01 00:00:00
abstract:UNLABELLED:The authors present the results of their follow-up studies of data from the last four years on patients with congenital ventriculomegaly. OBJECTIVE:To study the psychomotor and mental developmental outcome of neonates with congenital ventriculomegaly diagnosed prenatally. In addition, patients were also cla...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.1999.067
更新日期:1999-01-01 00:00:00
abstract::Numerous tests have been proposed for the assessment of fetal condition during the antenatal period. This preliminary report suggests the possibility of exposing the fetus-in-utero to alternating light during amnioscopy, with simultaneous registration of the fetal heart rate. This simple, non-invasive, inexpensive tes...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1980.8.1.38
更新日期:1980-01-01 00:00:00
abstract::Objective To evaluate fetal behavioral differences between singleton and twin fetuses before 20 weeks of gestation using four-dimensional (4D) ultrasound. Methods 4D ultrasound was used to examine fetal movements in 58 singleton and 48 twin normal fetuses at 12-19 weeks. The frequencies of eight fetal movements were a...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2017-0158
更新日期:2018-10-25 00:00:00
abstract::This study was undertaken to measure the extent of nonshivering thermogensis (NST) in brown adipose tissue of human newborns receiving routine thermal care and to examine the influence of oxygen levels at birth on the initiation of NST. Fifteen human neonates were studied in an incubator set at 31-31 degrees C. Thermo...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1997.25.5.447
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:to assess the relationship between maternal and umbilical serum concentrations of matrix metalloproteinases (MMP)-2,8,9, the soluble receptor for advanced glycation end products (sRAGE) and IL-10 and premature delivery and fetal inflammation. METHODS:maternal serum levels of MMPs, sRAGE, IL-10 and C-reactiv...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2010.092
更新日期:2010-11-01 00:00:00
abstract::A new design of vacuum extractor cup--'the New Generation cup'--has recently been introduced into clinical practice. Its major modification is a traction cord which passes around the rim of the cup for 180 degrees and is free to slide within the rim. Claims that this design 'enables the operator to pull obliquely with...
journal_title:Journal of perinatal medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1515/jpme.1986.14.2.95
更新日期:1986-01-01 00:00:00
abstract:AIMS:To investigate the incidence of severe fetal-to-maternal transfusion after delivery and to identify risk factors. MATERIAL AND METHODS:In a prospective study at the Department of Obstetrics, Charité, Campus Virchow-Klinikum, Berlin, Germany, we analyzed the incidence of severe fetal-to-maternal transfusion (>10 m...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2004.047
更新日期:2004-01-01 00:00:00
abstract::C. reactive protein (CRP) estimations were performed prospectively on 30 consecutive admissions of very low birth weight infants to a Regional neonatal intensive care unit. The samples were analysed by a recently described, rapid intralipid agglutination assay and by a reference turbidimetric technique. Two hundred an...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1990.18.3.157
更新日期:1990-01-01 00:00:00
abstract::To determine the optimal time of delivery, in terms of lowest risk of peripartum complications, the relative incidences of the parameters. Abnormal cardiotocogram (CTG), operative vaginal delivery, Apgar < 7 at 1 and 5 min, artery cord blood pH < 7.20, blood loss > 500 ml, epidural anesthesia, and Cesarean section, we...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1996.24.6.661
更新日期:1996-01-01 00:00:00
abstract:Objectives:The purpose of this study is to follow the birth process with transperineal ultrasonography (TPU) and predict the delivery method using angle of progression (AOP). Methods:The study included 134 patients. The AOP was examined with TPU in the lithotomy position applied at 4-h intervals, not at a time of stra...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2020-0323
更新日期:2020-09-07 00:00:00
abstract::The interest in the limit of viability originated from various sources, including legal requirements, the rejection of mechnical life support, competition for resources, concerns about handicaps, and proximity to the fetus with its limited rights. Gestational age was determined from menstrual history by Hippocratic wr...
journal_title:Journal of perinatal medicine
pub_type: 历史文章,杂志文章
doi:10.1515/jpm.2011.056
更新日期:2011-09-01 00:00:00
abstract::FHR monitoring and microanalysis of fetal blood are mutually complementary procedures, and optimal knowledge of the fetal state is achieved by making use of both, the former for the preliminary screening of all cases at risk and the latter for the purpose of deciding on obstetric management where pathological changes ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1975.3.1.53
更新日期:1975-01-01 00:00:00
abstract::Many decisions in pregnancy are based on one or two casual blood pressure estimations made in the antenatal clinic. No previous study has challenged the validity of this practice or attempted to discover whether there are significant differences between the blood pressures of pregnant women when they are measured in t...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1991.19.1-2.133
更新日期:1991-01-01 00:00:00
abstract::Anencephaly in triplets and pergonal induced pregnancies is a very rare incident. Associated cleft lip and palate has never been reported in these case. In this paper we report the first case of an anencephalic infant with cleft lip and palate in a set of pergonal-induced discordant triplet pregnancy. ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1992.20.3.241
更新日期:1992-01-01 00:00:00