Abstract:
:Current approaches to the detection of patients at risk for preterm delivery (PTD) have focused on the diagnosis of preterm labor. However, these approaches are complicated by treatment biases and our inability to convincingly differentiate preterm labor from Braxton-Hicks contractions. Moreover, preterm labor with intact membranes accounts for only one-half of all spontaneous PTDs since uterine contractions follow preterm premature rupture of the membranes (PROM) in an additional 50% of cases. Clinical dogma holds that the prevention of PTD requires the early detection of at risk patients. However, clinical indicators of PTD risk including cervical change, uterine contractions, vaginal bleeding, maternal demographic featuers and obstetrical history have poor sensitivity and/or specificity. Fortunately, an improved understanding of the association between preterm parturition and cervical, chorionic and decidual extracellular matrix degradation has led to a number of promising new biochemical indices of the proteolytic processes leading to PTD. These include measurement of serum collagenase activity and assessment of cervico-vaginal granulocyte elastase and oncofetal fibronectin levels. It remains to be seen, however, whether an improved detection of patients at risk will lead to a reduction in the occurrence of PTD.
journal_name
J Perinat Medjournal_title
Journal of perinatal medicineauthors
Lockwood CJ,Dudenhausen JWdoi
10.1515/jpme.1993.21.6.441subject
Has Abstractpub_date
1993-01-01 00:00:00pages
441-52issue
6eissn
0300-5577issn
1619-3997journal_volume
21pub_type
杂志文章,评审abstract::Vaginal bleeding may be present in up to 30% of patients presenting with signs and symptoms of a rupture of the fetal membranes (ROM). The presence of blood may lead to false positive results with biochemical markers. The data presented in this study came from a multi-centric prospective observational clinical study t...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,多中心研究
doi:10.1515/jpm-2014-0227
更新日期:2015-07-01 00:00:00
abstract::Maternal perception of fetal movement in response to vibro-acoustic stimulation was compared with antenatal fetal heart rate monitoring as a test of fetal well-being in a population of gravidae with high-risk pregnancies (n = 517), admitted to the high-risk ward at Danderyd Hospital, Karolinska Institutet; a total of ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1992.20.4.267
更新日期:1992-01-01 00:00:00
abstract::Considerable evidence exists for marked beneficial effects of omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) during pregnancy. The omega-3 LC-PUFA docosahexaenoic acid (DHA) is incorporated in large amounts in fetal brain and other tissues during the second half of pregnancy, and several studies have provide...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/JPM.2007.030
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To examine the population-based trend for cesarean births in twin pregnancies for the last 13 years in Slovenia, and to find correlates for this trend. METHODS:We evaluated data from the Slovenian national perinatal information system (NPIS) of all twin pairs born at ≥24 weeks during the period 1997-2009 (n=...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2011.129
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:The Apgar score is used worldwide to assess the newborn infant shortly after birth. Apgar scores, including mean scores and those with high cut-off scores, have been used to support claims that planned home birth is as safe as hospital birth. The purpose of this study was to determine the distribution of 5 m...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2014-0003
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To determine whether first-trimester measurements of maternal serum PAPP-A and free beta hCG levels were associated with adverse pregnancy outcomes. STUDY DESIGN:First trimester maternal serum free beta hCG and PAPP-A were measured in 490 singleton pregnancies. Pregnancies were followed by the fetal-maternal...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2006.026
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:to assess the relationship between maternal and umbilical serum concentrations of matrix metalloproteinases (MMP)-2,8,9, the soluble receptor for advanced glycation end products (sRAGE) and IL-10 and premature delivery and fetal inflammation. METHODS:maternal serum levels of MMPs, sRAGE, IL-10 and C-reactiv...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2010.092
更新日期:2010-11-01 00:00:00
abstract::C. reactive protein (CRP) estimations were performed prospectively on 30 consecutive admissions of very low birth weight infants to a Regional neonatal intensive care unit. The samples were analysed by a recently described, rapid intralipid agglutination assay and by a reference turbidimetric technique. Two hundred an...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1990.18.3.157
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:To assess risk factors for adverse perinatal and neonatal outcomes in "well-selected" singleton vaginal breech deliveries at term. METHODS:During the time span from January 2008 up to April 2015 a total of 786 singleton term breech deliveries with a planned vaginal delivery were identified in a retrospective...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2015-0342
更新日期:2017-04-01 00:00:00
abstract::The placenta is the principal organ regulating respiratory, nutritional, endocrine and metabolic functions on behalf of the developing fetus. Changes in gene expression patterns of placenta-specific genes may influence fetal growth. We profiled the expression of 17 genes related to placenta functioning in term placent...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2017-0064
更新日期:2017-10-26 00:00:00
abstract::Listeria is commonly found in processed and prepared foods and listeriosis is associated with high morbidity and mortality. Preventative measures are well prescribed and monitoring and voluntary recall of contaminated products has resulted in a 44% reduction in the prevalence of perinatal listeriosis in the USA. Pregn...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpm.2011.035
更新日期:2011-05-01 00:00:00
abstract:AIMS:Psychosocial stress during pregnancy (PSP) is a risk factor of growing interest in the etiology of preterm birth (PTB). This literature review assesses the published evidence concerning the association between PSP and PTB, highlighting established and hypothesized physiological pathways mediating this association....
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpm-2012-0295
更新日期:2013-11-01 00:00:00
abstract:AIM:We investigated the combined effects of intra-amniotic lipopolysaccharide (LPS) and maternal betamethasone (BMZ) on alveolarization using a newborn rat model. METHODS:LPS (1.0 μg/sac) or vehicle was injected into the amniotic sacs of pregnant rats and BMZ (170 μg/kg) or vehicle was injected intramuscularly into th...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2013-0063
更新日期:2013-11-01 00:00:00
abstract::A retrospective cohort study on nosocomial infections (NI) in the neonatal intensive care unit (NICU) was performed in the Children's Hospital of Zhejiang University, Hangzhou district, China. The most common infection site was pneumonia and bloodstream infection. Low admission age, long NICU stay, and mechanical vent...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2010.063
更新日期:2010-07-01 00:00:00
abstract:UNLABELLED:The authors present the results of their follow-up studies of data from the last four years on patients with congenital ventriculomegaly. OBJECTIVE:To study the psychomotor and mental developmental outcome of neonates with congenital ventriculomegaly diagnosed prenatally. In addition, patients were also cla...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.1999.067
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:The transcatheter pelvic arterial embolization (TAE) is effective for postpartum hemorrhage (PPH). There has been a little information about the factors for ineffectiveness of TAE. The aim of this study was to determine factors associated with TAE failure for PPH. STUDY DESIGN:Fifty-five women who underwent ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2013-0242
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Influenza presents with increased morbidity and mortality in children ≤5 months of age. Vaccination of caregivers is indicated, but immunization rates are estimated at only 30%. The 2009 New York State Neonatal Influenza Protection Act (NIPA) mandated offering of influenza vaccine to caregivers during the po...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2014-0248
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To assess longitudinally the changes in cervical volume and vascularization during the peripartum period using three-dimensional ultrasound (3D US) and power Doppler and to determine whether these measures change with gestational complications. METHODS:Longitudinal measurements of cervical dimensions by tran...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2010.087
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To study the side effects of prolonged prostaglandin therapy especially hyperostosis and other musculoskeletal changes. METHODS:Case files of the neonates, with cyanotic heart disease, who had received prostaglandin infusion from early days of life, were reviewed. Patients with periosteal changes were identi...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2000.060
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To compare epidemiological and obstetric characteristics, etiology and next pregnancy outcomes of women with primary vs. secondary recurrent pregnancy loss (RPL). STUDY DESIGN:A retrospective cohort study, including 420 patients with two or more consecutive pregnancy losses followed by a subsequent (index) p...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2011-0315
更新日期:2012-02-29 00:00:00
abstract:OBJECTIVE:To assess mid-trimester amniotic fluid concentrations of interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, and lipopolysaccharide binding protein (LBP) in pregnancies with normal outcome and correlate them with gestational week (GW), parity, and fetal gender. METHODS:Cytokine concentrations were measu...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2011.041
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To compare obstetrical and neonatal outcomes of vaginal deliveries complicated by shoulder dystocia, according to the length of second stage of labor. METHODS:We conducted a retrospective cohort study of 177 shoulder dystocia cases that were divided into three categories according to second stage duration (1...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2011-0253
更新日期:2012-03-29 00:00:00
abstract::Background Thyroid cancer is one of the most common cancers in women of reproductive age. Our purpose was to evaluate the association between thyroid cancer and maternal and neonatal outcomes of pregnancy. Methods We conducted a retrospective cohort study using the Healthcare Cost and Utilization Project, Nationwide I...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2019-0039
更新日期:2019-09-25 00:00:00
abstract:OBJECTIVE:The purpose of the study was to determine EKG and 2-D echocardiographic criteria of ventricular dominance in preterm infants and select those by which ventricular dominance could be established by EKG alone. METHODS:A database was constructed from EKG and 2-D echocardiographic measurements on preterm infants...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.1999.040
更新日期:1999-01-01 00:00:00
abstract::An infant is reported who was identified antenatally to have an extralobar sequestration and a pleural effusion. Chronic drainage of the effusion was achieved by placement of a pleuroamniotic shunt. After delivery the infant underwent several thoracocenteses and then definitive surgery to remove an extralobar sequestr...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1996.24.4.335
更新日期:1996-01-01 00:00:00
abstract::The value of testing for inherited thrombophilia in pregnancy has been debated in literature with regard to its utility in preventing adverse obstetrical outcomes or identifying women at risk for it. In this commentary, an evidence based approach is used to investigate the strength of association between thrombophilia...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2014-0075
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To examine trends in twin gestational age over time, with adjustment for potential confounding factors, and to assess twin pair mortality and respiratory support over time. METHODS:Rates of preterm births, respiratory support, and neonatal mortality were calculated for 21,569 twin pairs born from 1980 to 200...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2010.020
更新日期:2010-05-01 00:00:00
abstract::Diagnostic ultrasound has been used for many years with a remarkable history of safety during the standard clinical practice. Introduction of color and pulsed Doppler modes resulted with higher levels of transmitted and absorbed ultrasonic energy. This fact raised the question for the safety of its use in early pregna...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/JPM.1999.057
更新日期:1999-01-01 00:00:00
abstract::A fatality from a tracheoesophageal fistula (TEF) in two extremely low birth weight infants is presented. The sudden onset of intractable respiratory failure accompanied by the absence of chest movement and breathing sounds was observed. The typical clinical symptoms were concealed because the infants required mechani...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2002.037
更新日期:2002-01-01 00:00:00
abstract::Acute myocardial infarction (AMI) during pregnancy is usually transmural and occurs in late pregnancy with a peak incidence during the peripartum or postpartum periods. We report a pregnancy-related AMI, which occurring as early as the first trimester, was treated conservatively with antithrombotic and anti-ischemic d...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2004.127
更新日期:2004-01-01 00:00:00