Abstract:
:Vaginal bleeding may be present in up to 30% of patients presenting with signs and symptoms of a rupture of the fetal membranes (ROM). The presence of blood may lead to false positive results with biochemical markers. The data presented in this study came from a multi-centric prospective observational clinical study that, for the first time, systematically evaluated the performance of placental alpha microglobulin-1 (PAMG-1) and insulin-like growth factor binding protein-1 (IGFBP-1) detecting tests in 151 women with vaginal bleedings as well as signs and symptoms indicative of ROM. Our data showed better performance for the PAMG-1 compared with the IGFBP-1 detecting tests in all quality parameters evaluated. In detail, sensitivity (SN) was 97.8% (91.0%), specificity (SP) was 91.5% (75.0%), positive predictive value (PPV) was 94.6% (83.5%) and negative predictive value (NPV) was 96.4% (85.7%) for PAMG-1 tests (and IGFBP-1 tests, respectively). A major difference between both tests was related to the number of non-evaluable test results (e.g., hidden bands due to blood smear on the test strips). While 2% of all results were not evaluable for PAMG-1 tests, this artifact appeared in 11% of the results obtained with IGFBP-1 tests. This difference and also those in Specificity and PPV were statistically significant, demonstrating superiority of PAMG-1 over IGFBP-1 detecting tests. In conclusion, the PAMG-1 detecting test was significantly less susceptible to interference by blood than the IGFBP-1 detecting test.
journal_name
J Perinat Medjournal_title
Journal of perinatal medicineauthors
Ramsauer B,Duwe W,Schlehe B,Pitts R,Wagner D,Wutkewicz K,Chuvashkin D,Abele H,Lachmann Rdoi
10.1515/jpm-2014-0227subject
Has Abstractpub_date
2015-07-01 00:00:00pages
417-22issue
4eissn
0300-5577issn
1619-3997pii
/j/jpme.ahead-of-print/jpm-2014-0227/jpm-2014-0227journal_volume
43pub_type
杂志文章,多中心研究abstract::The objective of this study was to analyse the relation between severity of maternal condition at the time of intensive care unit (ICU) admission and various individual and institutional factors. This study analysed data from a retrospective population-based study in three French regions during 1991. The population st...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1998.26.5.354
更新日期:1998-01-01 00:00:00
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journal_title:Journal of perinatal medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-01-01 00:00:00
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journal_title:Journal of perinatal medicine
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journal_title:Journal of perinatal medicine
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of perinatal medicine
pub_type: 杂志文章
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journal_title:Journal of perinatal medicine
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更新日期:2012-01-19 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2010.095
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journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1988.16.3.249
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1515/jpme.1987.15.5.453
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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journal_title:Journal of perinatal medicine
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更新日期:1975-01-01 00:00:00
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