Abstract:
AIM:Inhaled nitric oxide (iNO) is used to treat neonates with hypoxic respiratory failure (HRF). The aim of this study was to determine clinical characteristics and factors associated with non-response to iNO therapy that may assist in clinical management and weaning strategies. METHODS:Retrospective chart review. The study cohort included gestational age ≥34 weeks' infants with acute HRF who received iNO within 7 days of birth. Subjects were stratified as responders or non-responders to iNO. Non-responders were defined as infants with failure to improve their PaO2 >20 mm Hg within 6 h of iNO initiation, need for extracorporeal membrane oxygenation (ECMO), or mortality. Clinical and laboratory characteristics were then compared between groups. RESULTS:Forty four subjects were included. There were 31 responders and 13 non-responders to iNO therapy. Regression analysis showed significant correlation between a non-response to iNO therapy and changes in PaO2 and pH levels. We found for every 10 mm Hg decrease in PaO2 immediate post-iNO therapy there is a 17.5% decrease in the likelihood of responding to iNO (odds ratio [OR] 0.98, P=0.012). Similarly, for every 0.15 point decrease in pH, there is a 16.3% increased chance of not responding to iNO therapy (OR 1.16, P=0.002). The need for pressor support prior to iNO initiation was also found to be associated with a non-response (OR 2. 94, P=0.034). CONCLUSIONS:Hypotension requiring treatment with pressors at the time of iNO therapy, as well as changes in pH and PaO2 after iNO initiation can be used as early clinical predictors to identify patients quickly who may be iNO non-responders.
journal_name
J Perinat Medjournal_title
Journal of perinatal medicineauthors
Morel AA,Shreck E,Mally PV,Kim Y,Bailey SM,Wachtel EVdoi
10.1515/jpm-2015-0210subject
Has Abstractpub_date
2016-08-01 00:00:00pages
663-8issue
6eissn
0300-5577issn
1619-3997pii
/j/jpme.ahead-of-print/jpm-2015-0210/jpm-2015-0210journal_volume
44pub_type
杂志文章abstract:OBJECTIVE:To examine the population-based trend for cesarean births in twin pregnancies for the last 13 years in Slovenia, and to find correlates for this trend. METHODS:We evaluated data from the Slovenian national perinatal information system (NPIS) of all twin pairs born at ≥24 weeks during the period 1997-2009 (n=...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2011.129
更新日期:2012-04-01 00:00:00
abstract:AIMS:To investigate localization and concentration of adhesion molecules in the human lower uterine segment during preterm parturition. METHODS:In a prospective study biopsy specimens from the lower uterine segment of 43 patients undergoing cesarean section at 24 + 0 to 36 + 4 weeks' gestation were immunostained for i...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2001.069
更新日期:2001-01-01 00:00:00
abstract:AIM:The current therapeutic strategies to reduce macrosomia rates in gestational diabetes (GDM) have focused on the normalizing of maternal glucose levels. The aim of our study was 1.) to compare maternal glycemic values with the presence of fetal macrosomia at different gestational ages (GA) and with LGA at birth in a...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2002.046
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To compare obstetrical and neonatal outcomes of vaginal deliveries complicated by shoulder dystocia, according to the length of second stage of labor. METHODS:We conducted a retrospective cohort study of 177 shoulder dystocia cases that were divided into three categories according to second stage duration (1...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2011-0253
更新日期:2012-03-29 00:00:00
abstract::Status and school achievement of 129 children born in Hessen between 1988 and 1992 and notified by a repeatedly elevated concentration of TSH in neonatal screening were evaluated. Interviews of mothers, teachers and pediatricians were used to score the development and educational achievements, respectively. A total of...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2005.097
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To evaluate whether uterotrophic agents increase the risk of fatal hemorrhagic brain stroke. METHODS:Between 1991 and 1992, there were 230 maternal deaths among 2,420,000 pregnant women in Japan and the causes of these deaths was investigated in 1994. Using information provided in this report, we identified ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2010.116
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To determine whether an amnioreduction via bulging membranes (AVBM) and cerclage could be useful in 17 women with singleton gestations demonstrating hourglass membranes bulging out of the cervix or vaginal orifice. METHODS:We used the following selection criteria for AVBM under ultrasonographic guidance usin...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2004.026
更新日期:2004-01-01 00:00:00
abstract::Cerebral palsy (CP) is the most common cause of severe physical disability in childhood. The precise etiological factor for the development of the majority of cases of CP has not been identified, however, prematurity is considered to be the leading identifiable risk factor. During the last decade, intrauterine infecti...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/JPM.2006.001
更新日期:2006-01-01 00:00:00
abstract::Concentrations of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) were measured in blood obtained from pregnant women to elucidate the fluctuations in the fibrinolytic system which occur during the course of pregnancy. The t-PA activity was measured with a modified bioimmunoassay using an...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1994.22.2.113
更新日期:1994-01-01 00:00:00
abstract:AIM:To determine the association, if any, between placental architecture findings assessed ultrasonographically at 22 and 36 weeks and placental histology. METHODS:There was prospective recruitment of 1011 low-risk primigravids from the antenatal clinic at the Rotunda Hospital, Dublin, Ireland. Ultrasound of the place...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2013-0015
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:Congestive heart failure (CHF) may be present in fetuses with hydrops fetalis (HF) and the severity is difficult to quantitate. Differential ventricular dysfunction may be present in the fetus with CHF. A non-geometric measure of ventricular function that is not afterload dependent would be useful to measu...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2001.055
更新日期:2001-01-01 00:00:00
abstract::A prospective trial to investigate feasibility of vaginal delivery after more than one cesarean section, and the safety of vaginal delivery for mother and neonate. Twenty-six pregnant women with a history of two or more cesarean sections were admitted to the delivery room and accepted trial of labor under internal fet...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1994.22.1.13
更新日期:1994-01-01 00:00:00
abstract::In preterm infants, feeding with human milk (HM) is a very effective intervention for the prevention of infections and necrotizing enterocolitis (NEC), and for potentially improved neurocognitive and cardiovascular outcomes in the long-term. Hospitals and physicians are advised to recommend HM for preterm and other hi...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,实务指引
doi:10.1515/jpm.2010.064
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:To assess the association of chronic hepatitis B virus (HBV) infection with preterm birth (PTB). METHODS:A cohort of 20,498 pregnant women (497 HBV carriers with 20,001 non-HBV controls) with normal alanine aminotransferase (ALT) levels was selected from the Obstetrics & Gynecology Hospital of Nantong Unive...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,meta分析
doi:10.1515/jpm-2016-0201
更新日期:2017-11-27 00:00:00
abstract::A prospective study was conducted to determine the effects of maternal smoking and alcohol consumption during pregnancy on the birth weight of fetuses in an unselected study population. Several confounding factors were taken into account. The main factors associated with an increase of birth weight of both sexes were ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1988.16.3.249
更新日期:1988-01-01 00:00:00
abstract::In order to evaluate the determinants of high and low ponderal indices in triplets, we analyzed prospectively collected data from a cohort of 2181 triplet births. Low and high neonatal ponderal indices (birth weight/[length]3) were defined as below or above 1 SD from the mean. The mean ponderal index was of 2.4 +/- 0....
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2004.012
更新日期:2004-01-01 00:00:00
abstract::The somatic growth of a regional birth cohort of 351 preterm infants was followed during their first two years. The measurements of weight, height, head and thorax circumferences took place at the well-baby clinics run by public health nurses at 3, 6, 12, 18 and 24 months of conceptional age. The growth of the preterm...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1989.17.1.41
更新日期:1989-01-01 00:00:00
abstract:AIM:P-selectin is a member of selectin family (E, L- and P-selectins) which plays a crucial role in reproduction and hemostasis as well as in pathogenesis of preeclampsia. There are no regular studies on P-selectin in placenta and it is not clear whether it is present in gestational myometrium. In the present study, we...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2008.037
更新日期:2008-01-01 00:00:00
abstract::The aim of the study was to compare gradients of skin surface temperature on the arm and hand and to evaluate differences in the skin microcirculation reactivity between pregnant and non-pregnant women. We used the prototype of a highly sensitive thermograph system for the measurements. Eight healthy, non-pregnant wom...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1990.18.5.383
更新日期:1990-01-01 00:00:00
abstract:AIM:To examine the gestational age-specific distribution of twin birth weight discordance. METHODS:We analyzed all liveborn twin sets between 28 and 40 weeks' gestation from the United States 1995-1998 Multiple Matched Birth Data Set compiled by the National Center for Health Statistics. We calculated the 50th and 95t...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2005.022
更新日期:2005-01-01 00:00:00
abstract:AIMS:The number of fetuses with an abnormal increased first trimester nuchal translucency (NT), but confirmed normal karyotype and anatomy is relatively small and therefore a challenge for prenatal counseling. Universal guidelines are still needed for a systematic work-up, how to decide on the rewarding cut-off for thi...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/JPM.2005.036
更新日期:2005-01-01 00:00:00
abstract::We reviewed the literature on the use of inhaled nitric oxide and the influence of supplemental oxygen on bronchopulmonary dysplasia (BPD), and the role of endogenous nitric oxide-synthase, vascular endothelial growth factor, the interplay of nitric oxide and superoxide, protein nitration and the nuclear factor kappa ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/JPM.2008.065
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Some women exhibit a gradual decrease in antithrombin activity until the time of delivery, with antithrombin activity reaching <65% of the normal level (pregnancy-induced antithrombin deficiency, PIATD). However, the clinical features of such women are not well understood and are unfamiliar to many obstetric...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpm.2011.026
更新日期:2011-07-01 00:00:00
abstract::Bronchial reactivity was compared among mothers of neonates with unexplained premature delivery and mothers of preterm neonates with known etiology of prematurity as well as mothers who delivered their children at term. Bronchial reactivity was measured by unspecific bronchial provocation testing with histamine. A sig...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1989.17.2.151
更新日期:1989-01-01 00:00:00
abstract::The outbreak of the SARS-CoV-2 elicited a surge in publications. Obstetric reports were with few exceptions characterized by small sample sizes with potentially limited generalizability. In this review, evidence suggests increased susceptibility to COVID-19 in pregnancy; common pregnancy comorbidities may help explain...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/jpm-2020-0399
更新日期:2020-11-26 00:00:00
abstract::The value of testing for inherited thrombophilia in pregnancy has been debated in literature with regard to its utility in preventing adverse obstetrical outcomes or identifying women at risk for it. In this commentary, an evidence based approach is used to investigate the strength of association between thrombophilia...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2014-0075
更新日期:2015-03-01 00:00:00
abstract:AIMS:The purpose of this study was to determine whether head circumference (HC) catch-up is associated with improved neurocognitive development. DESIGN:A retrospective cohort study was conducted in 179 preterm very low birth weight (VLBW) (BW≤1500 g) infants. The infants were born in 2000-2002 and were followed to the...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2011.049
更新日期:2011-09-01 00:00:00
abstract::A delay of more than one month between the birth of twins is an unusual occurrence presenting the obstetrician and the neonatalogist with many questions regarding the management of the case. There is the risk of prematurity for the second twin as labor has already occurred in the pregnancy. There is also a risk of inf...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1986.14.3.201
更新日期:1986-01-01 00:00:00
abstract::On 11 near term pregnant sheep the response of the fetal transcutaneous oxygen partial pressure (tcPO2) was compared with the alteration of the oxygen saturation (SO2) and the PO2 in the fetal aorta (FA), fetal heart rate (FHR) and fetal arterial blood pressure (FA BP) following the reduction of uterine blood flow (UB...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1980.8.2.85
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:To examine the impact of maternal obesity on completion of fetal anomaly screening. METHODS:A retrospective analysis of 500 anomaly scans (19+0-21+6 weeks) was included. Women were categorised according to the World Health Organisation (WHO) body mass index (BMI) classification: normal weight (18.50-24.99 kg...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2016-0048
更新日期:2017-12-20 00:00:00