Abstract:
:The aim of the present investigation is to study the effect of amniotic fluid myoglobin on prostaglandin synthesis by the fetal membranes. The paper presents results of radioimmunologic studies of myoglobin levels in various biological fluids during pregnancy: amniotic fluid, maternal serum samples obtained from an antecubital vein and the cervix, and neonatal urine. Amniotic fluid myoglobin levels were found to be significantly higher at term. Our results suggest that amniotic fluid myoglobin is likely to be derived from the fetus and excreted into amniotic fluid through fetal urine. Incubation of the fetal membrane with amniotic fluid, neonatal urine, and commercially available myoglobin enhanced phospholipase A2 activity, as well as arachidonic acid and prostaglandin F2 alpha production was compared to incubation with normal saline. The addition of anti-myoglobin antibodies to incubation media was found to block these effects. The results of our study show that myoglobin activates prostaglandin synthesis by the fetal membranes and stimulates the onset of labor.
journal_name
J Perinat Medjournal_title
Journal of perinatal medicineauthors
Orlov VI,Pogorelova TN,Melkonova KYdoi
10.1515/jpme.1996.24.5.495subject
Has Abstractpub_date
1996-01-01 00:00:00pages
495-500issue
5eissn
0300-5577issn
1619-3997journal_volume
24pub_type
杂志文章abstract::Bronchial reactivity was compared among mothers of neonates with unexplained premature delivery and mothers of preterm neonates with known etiology of prematurity as well as mothers who delivered their children at term. Bronchial reactivity was measured by unspecific bronchial provocation testing with histamine. A sig...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1989.17.2.151
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:The receptor for advanced glycation end products, RAGE, plays an important role in the pathogenesis of several diseases. sRAGE, soluble receptor for advanced glycation end products, is an inhibitor of the pathological effect mediated via RAGE. The aim of this study was to assess the usefulness of measuring sR...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2008.080
更新日期:2008-01-01 00:00:00
abstract::Computerised cardiotocograph analysis has been used in our medical antenatal clinic for women with insulin dependent diabetes mellitus for five years. We had observed that many of the patients failed the computer criteria and wished to examine this finding in more detail. All cardiotocographs from 40 pregnant women wi...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1998.26.2.102
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To compare obstetrical and neonatal outcomes of vaginal deliveries complicated by shoulder dystocia, according to the length of second stage of labor. METHODS:We conducted a retrospective cohort study of 177 shoulder dystocia cases that were divided into three categories according to second stage duration (1...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2011-0253
更新日期:2012-03-29 00:00:00
abstract::The fetal electrocardiogram (FECG) has been recorded from 155 women in labor using a fetal scalp electrode and a minicomputerized enhanced averaging technique. Fetal hypoxia, acidosis, and stress have been diagnosed by analysis of blood from the fetal scalp, and post delivery from full gas analysis from blood taken fr...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1986.14.6.399
更新日期:1986-01-01 00:00:00
abstract::This article looks at the association of maternal blood pressure with the blood pressure of the offspring from birth to childhood. The Barker hypothesis states that maternal and "in utero" attributes during pregnancy affect a child's cardiovascular health throughout life. We present an analysis of a unique dataset tha...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2014-0038
更新日期:2015-11-01 00:00:00
abstract::It is well known that in pregnancy dehydroepiandrosterone-sulphate (DHEAS) (90% synthetized by the fetal adrenals, 10% by the maternal ones) is converted into estrogens mainly in the placenta. In order to evaluate the steroid metabolizing capacity of the placental enzymatic complex under load conditions, a test was de...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1979.7.3.149
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:To assess risk factors for adverse perinatal and neonatal outcomes in "well-selected" singleton vaginal breech deliveries at term. METHODS:During the time span from January 2008 up to April 2015 a total of 786 singleton term breech deliveries with a planned vaginal delivery were identified in a retrospective...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2015-0342
更新日期:2017-04-01 00:00:00
abstract::Universally 4 million newborns die and another 4 million are stillborn every year. 98% of these neonatal deaths take place in the developing countries. Looking at the state of the world's newborns one can see that neonatal mortality rate is about 4-5 per 1000 in the developed countries and nearly 10 fold this in the d...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/JPM.2003.060
更新日期:2003-01-01 00:00:00
abstract::Objective To determine whether the risk of intra-amniotic infection/inflammation and spontaneous preterm delivery (SPTD) varies as a function of the concentration of cervical fetal fibronectin (fFN) in patients with preterm labor and intact membranes. Methods This prospective study included 180 patients with preterm l...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2018-0351
更新日期:2019-04-24 00:00:00
abstract::A new design of vacuum extractor cup--'the New Generation cup'--has recently been introduced into clinical practice. Its major modification is a traction cord which passes around the rim of the cup for 180 degrees and is free to slide within the rim. Claims that this design 'enables the operator to pull obliquely with...
journal_title:Journal of perinatal medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1515/jpme.1986.14.2.95
更新日期:1986-01-01 00:00:00
abstract::The somatic growth of a regional birth cohort of 351 preterm infants was followed during their first two years. The measurements of weight, height, head and thorax circumferences took place at the well-baby clinics run by public health nurses at 3, 6, 12, 18 and 24 months of conceptional age. The growth of the preterm...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1989.17.1.41
更新日期:1989-01-01 00:00:00
abstract:AIMS:To develop a predictive model for assessing the risk of developing neonatal respiratory morbidity using lamellar body counts (LBCs) and gestational age (GA) to provide a more patient-specific assessment. METHODS:Retrospective cohort study of patients' ≥32 weeks' gestation who received amniocentesis with LBC analy...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2014-0310
更新日期:2016-08-01 00:00:00
abstract::The development of the human central nervous system (CNS) begins in the early embryonic period and proceeds through a sequence of very complicated processes long after delivery. Although the neurodevelopmental processes are genetically determined, their complexity and intensity implicates the vulnerability of the CNS ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,评审
doi:10.1515/JPM.2005.086
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To examine the proportion of iatrogenic births among all preterm births over a 26-year period. PATIENTS AND METHODS:A registry-based survey of preterm deliveries between 1987 and 2012 analyzed by the onset of labor: spontaneous with intact membranes, preterm premature rupture of membranes (PPROM) or iatrogen...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2015-0271
更新日期:2016-07-01 00:00:00
abstract::Objectives MR compatible incubators (MRcI) offer the examination of preterm and critically ill infants in controlled environment. The aim of the study was to compare objective and subjective image quality as well as diagnostic value of MRI brain examinations with and without using the MRcI. Thus, predictive value of b...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2020-0051
更新日期:2020-09-25 00:00:00
abstract::Changes in the technologies used in the latest generation of electronic fetal monitors has resulted generally in an improvement in the quality of the FHR data produced. However, in a number of instruments the use of inappropriate printers and signal processing has led to a degradation in the FHR trace. This may result...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1986.14.6.405
更新日期:1986-01-01 00:00:00
abstract:AIM:To evaluate the short-term effects of blood transfusion on iron status [hemoglobin, ferritin, soluble transferrin receptor (sTfR), and reticulocyte count], hepcidin, and erythropoietin in stable preterm infants. METHOD:Sixty-three preterm infants treated with red blood cell transfusions (RBCTs) were included. Veno...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm-2015-0361
更新日期:2016-10-01 00:00:00
abstract::In tocolysis with beta-sympathicomimetics Verapamil is administered universally to reduce the subjective and objective cardiovascular side effects. The efficacy of the calcium-antagonist has not yet been substantiated. This has now re-emerged as an important issue due to the increasing occurrance of cardiopulmonary co...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1981.9.5.235
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:This prospective observational study evaluated maternal symptoms and characteristics that predict successful labor induction with oral misoprostol. METHODS:A total of 244 consecutive women undergoing labor induction voluntarily completed a questionnaire about subjective sensations and pain scores during the ...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2011.032
更新日期:2011-05-01 00:00:00
abstract::Postpartum hemorrhage is a continuing problem occurring in 5-10% of all deliveries. Due to recent problems with blood transfusion, heterologous blood is nowadays restricted to life-threatening indications. As a consequence the clinician is faced with many patients suffering from overt symptoms of anemia. We therefore ...
journal_title:Journal of perinatal medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1515/jpme.1995.23.1-2.111
更新日期:1995-01-01 00:00:00
abstract::Results of continuous fetal tissue pH monitoring were compared to neonatal APGAR scores one minute after delivery in 81 successful tissue pH recordings. The sensitivity of the method (i.e. the ability of the method to find the low APGAR neonates) was 67 per cent using an APGAR score limit between 8 and 9 and a pH limi...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1980.8.3.158
更新日期:1980-01-01 00:00:00
abstract::An infant is reported who was identified antenatally to have an extralobar sequestration and a pleural effusion. Chronic drainage of the effusion was achieved by placement of a pleuroamniotic shunt. After delivery the infant underwent several thoracocenteses and then definitive surgery to remove an extralobar sequestr...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1996.24.4.335
更新日期:1996-01-01 00:00:00
abstract::Eighteen women were referred for fetal karyotyping because of advanced maternal age (over 38 years) later than 23 weeks' gestation. In order to obtain more rapid karyotypes, cordocentesis rather than amniocentesis was performed. All procedures were successful, leading to the obtention of normal karyotypes in all cases...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::A delay of more than one month between the birth of twins is an unusual occurrence presenting the obstetrician and the neonatalogist with many questions regarding the management of the case. There is the risk of prematurity for the second twin as labor has already occurred in the pregnancy. There is also a risk of inf...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1986.14.3.201
更新日期:1986-01-01 00:00:00
abstract:AIMS:The purpose of this study was to determine whether head circumference (HC) catch-up is associated with improved neurocognitive development. DESIGN:A retrospective cohort study was conducted in 179 preterm very low birth weight (VLBW) (BW≤1500 g) infants. The infants were born in 2000-2002 and were followed to the...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpm.2011.049
更新日期:2011-09-01 00:00:00
abstract:AIM:To analyze short-term neonatal outcome and the sampling to delivery interval in cases with severe intrapartum acidemia diagnosed with fetal scalp blood sampling (FBS). METHODS:This is a secondary analysis of data from a trial of 2992 women, who were, when indicated, randomized to either lactate or pH analyses by F...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章,随机对照试验
doi:10.1515/jpm.2011.062
更新日期:2011-09-01 00:00:00
abstract::We report the prenatal diagnosis of Wiedemann-Beckwith syndrome in the 28th week of pregnancy in a primigravida. The cause of hospitalization was severe polyhydramnios with premature labour. Sonography revealed macrosomia, nephromegaly, cysts of adrenal glands and a striking macroglossia with opened mouth in all contr...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/jpme.1989.17.5.351
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:The purpose of the study was to determine EKG and 2-D echocardiographic criteria of ventricular dominance in preterm infants and select those by which ventricular dominance could be established by EKG alone. METHODS:A database was constructed from EKG and 2-D echocardiographic measurements on preterm infants...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.1999.040
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To study the side effects of prolonged prostaglandin therapy especially hyperostosis and other musculoskeletal changes. METHODS:Case files of the neonates, with cyanotic heart disease, who had received prostaglandin infusion from early days of life, were reviewed. Patients with periosteal changes were identi...
journal_title:Journal of perinatal medicine
pub_type: 杂志文章
doi:10.1515/JPM.2000.060
更新日期:2000-01-01 00:00:00