Prenatal diagnosis of Wiedemann-Beckwith syndrome.

Abstract:

:We report the prenatal diagnosis of Wiedemann-Beckwith syndrome in the 28th week of pregnancy in a primigravida. The cause of hospitalization was severe polyhydramnios with premature labour. Sonography revealed macrosomia, nephromegaly, cysts of adrenal glands and a striking macroglossia with opened mouth in all controls. The combination of all these symptoms suggested the prenatal diagnosis of Wiedemann-Beckwith syndrome, which could be confirmed post partum after a normal delivery in the 33rd week of pregnancy. The newborn (2700 g, 48 cm) exhibited typical features of this syndrome as moderate hypoglycemia and polycythemia in addition to the sonographic finding. Pathogenetic aspects and differential diagnosis of macrosomia are discussed.

journal_name

J Perinat Med

authors

Wieacker P,Wilhelm C,Greiner P,Schillinger H

doi

10.1515/jpme.1989.17.5.351

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

351-5

issue

5

eissn

0300-5577

issn

1619-3997

journal_volume

17

pub_type

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