Abstract：
:Antibodies against bromelain-treated erythrocytes occurring in normal mice are germline gene-encoded IgM natural autoantibodies that are secreted by CD5+ B cells, and react primarily with phosphatidylcholine (PTC), but may crossreact with cardiolipin (aCL). Some of the IgM antiphospholipid antibodies (aPL) present in patients with the recently described primary antiphospholipid syndrome (PAPS) also react with PTC and could thus be natural autoantibodies akin to those found in mice. Patients with PAPS (n = 20) were found to have increased total B cells, as well as CD5 + B cells, in their peripheral blood, but normal total lymphocytes, as well as CD4 and CD8 T lymphocytes, compared to normal controls. The 6 PAPS patients with increased CD5+ B cells were found to have increased levels of IgM aPL, including aPTC. In them we also found a correlation between the number of CD5+ B cells and the levels of IgM aCL. Our findings suggest that within the family of aPLs present in patients with PAPS there may be some that could be IgM natural autoantibodies secreted by CD5+ B cells.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Velasquillo MC,Alcocer-Varela J,Alarcón-Segovia D,Cabiedes J,Sánchez-Guerrero Jsubject
Has Abstractpub_date
1991-09-01 00:00:00pages
501-5issue
5eissn
0392-856Xissn
1593-098Xjournal_volume
9pub_type
杂志文章abstract：:Cyclooxygenase-2 (COX-2) selective inhibitors are now extensively used for their anti-inflammatory and analgesic efficacy. Several large controlled trials provide evidence to support the proposition that they cause fewer major gastro-intestinal side effects and less toxicity than routine nonsteroidal anti-inflammatory...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
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更新日期：2001-11-01 00:00:00
abstract：OBJECTIVES:To compare the diagnostic performance between a vascular specialist and a rheumatologist not familiar with vascular ultrasound when applying the compression sign for the diagnosis of temporal arteritis. METHODS:Sixty consecutive patients with suspicion of giant cell arteritis were examined by both examiners...
journal_title：Clinical and experimental rheumatology
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更新日期：2015-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:The aim of the present work was to study the association between HLA alleles and Takayasu's arteritis in Mexican Mestizo patients. METHODS:The study included 26 Mexican Mestizo patients with Takayasu's arteritis and 99 healthy unrelated individuals. HLA-A, -B and -DR alleles were determined by polymerase cha...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：OBJECTIVES:Lymph node biopsies from patients with mixed cryoglobulinemia (MC) were investigated for: a) the presence of the hepatitis C virus (HCV) peptides C22 and C100; b) the degree of angiogenesis and of inflammatory infiltrate (macrophages and neutrophils); c) the distribution of laminin and type IV collagen, the ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
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更新日期：2017-05-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2016-01-01 00:00:00
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doi：
更新日期：2014-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2016-01-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2009-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2021-01-11 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2007-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2020-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,meta分析,评审
doi：
更新日期：2016-05-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2015-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 传,历史文章,杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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更新日期：2013-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2007-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2016-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
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pub_type： 杂志文章,评审
doi：
更新日期：2015-09-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1992-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 临床试验,杂志文章
doi：
更新日期：2011-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-03-01 00:00:00
