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Etoricoxib in ankylosing spondylitis: is there a role for active patients refractory to traditional NSAIDs?

Abstract：

OBJECTIVES:To evaluate the efficacy of etoricoxib in patients with axial ankylosing spondyloarthritis (AS) refractory to traditional NSAIDs. METHODS:This was an open label, multicentric, randomised, prospective (4 weeks with and open extension to 6 months), non-controlled study. Consecutive patients with axial AS refractory to traditional NSAID eligible for anti-TNF-α therapy were selected. The primary outcomes were the rate of patients with good clinical response (not eligible for anti-TNF-α therapy after etoricoxib) and the Assessment of Spondyloarthritis International Society response criteria for biologic therapies (ASASBIO) response at 4 weeks. Secondary outcomes included: ASAS20 and 40 responses, ASDAS-CRP response, BASDAI, BASFI, back and night back pain, global patient and physician assessment of the disease, and biologic parameters like C-reactive protein (CRP) at 2, 4 weeks and 6 months. RESULTS:A total of 57 axial AS patients were recruited, 46 men, with mean age of 43 years. After 4 weeks of treatment, 26 patients (46%) achieved a good clinical response and 11 (20%) an ASASBIO response. These results at 24 weeks were 19 (33%) and 13 (23%) respectively. All individual clinical variables improved significantly after 4 weeks of treatment. CRP serum levels decreased after 4 weeks but reached no statistical significance, although 30% of patients showed a normalisation of CRP. CONCLUSIONS:Etoricoxib provided a clear clinical improvement in around a third of patients with axial AS refractory to traditional NSAIDs. Special care should be required when deciding to start anti-TNF-α therapy; it seems reasonable to keep in mind these results of etoricoxib treatment.

journal_name

Clin Exp Rheumatol

journal_title

Clinical and experimental rheumatology

authors

Gratacós J,Moreno Martínez-Losa M,Font P,Montilla C,Fernández-Espartero C,Linares LF,Brito E,Oliva JC,Collantes-Estevez E,Etoricoxib Study Group.

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

94-9

issue

1

eissn

0392-856X

issn

1593-098X

pii

9508

journal_volume

34

pub_type

杂志文章,多中心研究,随机对照试验

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