Abstract:
OBJECTIVES:Behçet's disease (BD) is characterised by repeated acute inflammatory attacks with aphthous ulcers of the oral mucosa, uveitis of the eyes, skin symptoms, and genital ulcers. Although its aetiology is still unknown, there is evidence of the involvement of oral bacteria in systemic diseases. Various types of oral bacteria may be involved in the development and progression of BD. The present study investigated alterations in the oral flora of patients with BD in Mongolia. We collected saliva samples from the Mongolian BD group and healthy control (HC) group, and the oral flora were analysed using next-generation sequencer (NGS). METHODS:DNA was extracted from the unstimulated saliva samples from the 47 BD and 48 HC subjects. The DNA was amplified from the V3-V4 region of 16S rRNA using PCR, and the data were acquired using NGS. Based on the obtained data, we analysed the alpha diversity, beta diversity, and bacterial taxonomy of the salivary flora. RESULTS:Beta diversity differed significantly between the BD and HC flora, but no significant differences were observed in alpha diversity. We found that the proportions of three genera - an S24-7 family unknown species, a mitochondria family unknown species, and Akkermansia species associated with IL-10 production - were significantly lower in the BD than in the HC group. CONCLUSIONS:The reduced proportions of the S24-7 family and symbiotic Akkermansia species may be key phenomena in the oral flora of patients with BD.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Balt J,Uehara O,Abiko Y,Jamyanjav B,Jav S,Nagasawa T,Mori M,Horie Y,Fujita M,Lennikov A,Ohta T,Hiraoka M,Iwata D,Namba K,Ohno S,Kitaichi Nsubject
Has Abstractpub_date
2020-09-01 00:00:00pages
80-85issue
5eissn
0392-856Xissn
1593-098Xpii
16369journal_volume
38 Suppl 127pub_type
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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pub_type: 杂志文章
doi:
更新日期:2012-05-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
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