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Proprotein convertase subtilisin/kexin type 9 in rheumatoid arthritis.

Abstract：

OBJECTIVES:Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that regulates cholesterol metabolism through low-density lipoprotein receptor degradation and that has been linked with cardiovascular risk. The purpose of the present study was to examine whether PCSK9 levels are related to both abnormalities in the lipid profile and the severe atherosclerosis that occur in rheumatoid arthritis (RA) patients. METHODS:Cross-sectional study that encompassed 520 individuals; 326 patients with RA and 194 age- and sex-matched controls. PCSK9 and lipoproteins serum concentrations, standard lipid profile and carotid intima-media thickness (cIMT) and carotid plaques were assessed in patients and controls. A multivariable analysis, adjusted for standard cardiovascular risk factors, was performed to evaluate the influence of PCSK9 on RA related dyslipidaemia and subclinical carotid atherosclerosis. RESULTS:After adjusting for classical cardiovascular risk factors, lipid profile and statins, RA patients showed lower PCSK9 serum concentrations than controls (beta coefficient -45 95%CI [-53, -38] ng/ml, p=0.00). PCSK9 was associated with both cIMT and the presence of carotid plaques in RA patients. However, this association was lost after adjusting for classical cardiovascular risk factors. CONCLUSIONS:PCSK9 is down-regulated in patients with RA.

journal_name

Clin Exp Rheumatol

journal_title

Clinical and experimental rheumatology

authors

Ferraz-Amaro I,López-Mejías R,Ubilla B,Genre F,Tejera-Segura B,de Vera-González AM,González-Rivero AF,Olmos JM,Hernández JL,Llorca J,González-Gay MA

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

1013-1019

issue

6

eissn

0392-856X

issn

1593-098X

pii

10329

journal_volume

34

pub_type

杂志文章

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