当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Ligusticum chuanxiong prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis through a protein kinase A-dependent pathway.

Ligusticum chuanxiong prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis through a protein kinase A-dependent pathway.

Abstract：

:Ligusticum chuanxiong (LC) is a traditional Chinese herbal medicine used to treat various cardiovascular diseases. In this study, the butanol extract of LC was found to protect neuronal-like pheochromocytoma cells from serum deprivation-induced apoptosis. Both a serine/threonine kinase inhibitor and a specific protein kinase A (PKA) inhibitor blocked the protective effect of LC. A transcription inhibitor (actinomycin D) and a protein synthesis inhibitor (cyclohexamide) also attenuated the protective effect of LC, suggesting the requirement of gene expression for the protection of LC. On the other hand, LC increased both the formation of cyclic-AMP and the phosphorylation of the cyclic-AMP response element-binding protein (CREB), a downstream target of PKA and a nuclear transcription factor known for neuroprotective mechanism. Furthermore, LC-induced CREB phosphorylation and protective effect could be blocked by a PKA inhibitor and overexpression of the dominant negative CREB, respectively. Taken together, the protective mechanism of LC in antagonizing serum deprivation-induced PC12 cell apoptosis might be mediated through a PKA/CREB-dependent pathway.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Lin YL,Lee YC,Huang CL,Lai WL,Lin YR,Huang NK

doi

10.1016/j.jep.2006.08.012

subject

Has Abstract

pub_date

2007-02-12 00:00:00

pages

428-34

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(06)00409-0

journal_volume

109

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Modulation of quorum sensing-controlled virulence factors by Nymphaea tetragona (water lily) extract.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Nymphaea tetragona is a widely distributed ornamental species with ethnomedicinal uses in the treatment of diarrhea, dysentery, eruptive fevers, and infections. The anti-infectious activities of this herb have already been assessed to clarify its traditional use as a medicine. AIM OF STU...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.08.049

    authors： Hossain MA,Lee SJ,Park JY,Reza MA,Kim TH,Lee KJ,Suh JW,Park SC

    更新日期：2015-11-04 00:00:00

  • Preclinical safety evaluation of the aqueous extract from Mangifera indica Linn. (Anacardiaceae): genotoxic, clastogenic and cytotoxic assessment in experimental models of genotoxicity in rats to predict potential human risks.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Medicinal plants widely used by the population contain significant concentrations of biologically active compounds and, although they have proven pharmacological properties, can cause DNA damage and develop fatal diseases. AIM OF THE STUDY:The present study aimed to evaluate the genotoxi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112086

    authors： Villas Boas GR,Rodrigues Lemos JM,de Oliveira MW,Dos Santos RC,Stefanello da Silveira AP,Bacha FB,Aguero Ito CN,Cornelius EB,Lima FB,Sachilarid Rodrigues AM,Costa NB,Bittencourt FF,Freitas de Lima F,Paes MM,Gubert P,Oesterr

    更新日期：2019-10-28 00:00:00

  • Bioassay-guided isolation and evaluation of anti-osteoporotic polysaccharides from Morinda officinalis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Morinda officinalis is a well-known Chinese tonic herb that has shown clinical efficacy in the treatment of bone disease. However, its anti-osteoporotic potential and the M. officinalis polysaccharides (MOPs) responsible for activity require further investigation. AIM OF THE STUDY:This s...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113113

    authors： Zhang D,Zhang S,Jiang K,Li T,Yan C

    更新日期：2020-10-28 00:00:00

  • Effect of a traditional syrup from Citrus medica L. fruit juice on migraine headache: A randomized double blind placebo controlled clinical trial.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In Persian ethnomedicine several herbal remedies and functional foods have been used to treat migraine headache which are mostly summarized in Qarabadin-e-kabir (Aghili-Shirazi MH, 1773). One of them is Citron syrup (Sharbat-e-Balang) containing edible Citrus medica L. fruit juice and sug...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jep.2015.12.040

    authors： Jafarpour M,Yousefi G,Hamedi A,Shariat A,Salehi A,Heydari M

    更新日期：2016-02-17 00:00:00

  • Toxicology, genotoxicity, and cytotoxicity of three extracts of Solanum chrysotrichum.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Infusions of Solanum chrysotrichum (Schldl.) or "sosa" are employed in Traditional Mexican Medicine for the local and systemic treatment of skin and mucosal infections. Different studies have verified its antifungal effectiveness and therapeutic safety in superficial mycosis caused by der...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.08.039

    authors： Aguilar-Santamaría L,Herrera-Arellano A,Zamilpa A,Alonso-Cortés D,Jiménez-Ferrer E,Tortoriello J,Zúñiga-González G

    更新日期：2013-10-28 00:00:00

  • Alibertia edulis (L.C. Rich.) A.C. Rich - A potent diuretic arising from Brazilian indigenous species.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Although Alibertia edulis (L.C. Rich.) A.C. Rich decoction is used in Brazilian folk medicine due to its possible antihypertensive effect, this species has never been critically investigated as a hypotensive drug. So, the aim of this study was to evaluate the possible hypotensive and anti...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.12.024

    authors： de Santana Aquino DF,Signor Tirloni CA,Tolouei Menegati SE,Lima Cardoso CA,Heredia Vieira SC,Carmo Vieira MD,Simonet AM,Macías FA,Gasparotto A Junior

    更新日期：2017-01-20 00:00:00

  • Potential anthelmintic activity of Pelargonium endlicherianum Fenzl.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The decoction prepared from the roots of Pelargonium endlicherianum Fenzl. has been used for the treatment of gastrointestinal parasitism in small ruminants in Turkish Folk Medicine. AIM OF THE STUDY:The aim of the present study is to investigate in vitro anthelmintic activity of the ext...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.04.044

    authors： Kozan E,Küpeli Akkol E,Süntar I

    更新日期：2016-07-01 00:00:00

  • Safety evaluation of an Ayurvedic medicine, Arogyavardhini vati on brain, liver and kidney in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Arogyavardhini vati, an Ayurvedic polyherbal formulation has been used for liver and skin disorders in the Ayurvedic system of medicine. However, toxicity due to the presence of heavy metals in this traditional medicine is a matter of concern. AIM OF THE STUDY:To evaluate the safety of A...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.01.004

    authors： Kumar G,Srivastava A,Sharma SK,Gupta YK

    更新日期：2012-03-06 00:00:00

  • Bioactive Lignans from Zanthoxylum alatum Roxb. stem bark with cytotoxic potential.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Zanthoxylum alatum is used in traditional medicinal systems for number of disorders like cholera, diabetes, cough, diarrhea, fever, headache, microbial infections, toothache, inflammation and cancer. The aim of the present study was to evaluate Zanthoxylum alatum stem bark for its cytotox...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.12.039

    authors： Mukhija M,Lal Dhar K,Nath Kalia A

    更新日期：2014-02-27 00:00:00

  • Effect of some Indian herbs on macrophage functions in ochratoxin A treated mice.

    abstract：:The effect of Indian herbs namely, Asparagus racemosus, Tinospora cordifolia, Withania somnifera and Picrorhiza kurrooa on the functions of macrophages obtained from mice treated with the carcinogen ochratoxin A (OTA) was investigated. The chemotactic activity of murine macrophages was significantly decreased by 17 we...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(97)00072-x

    authors： Dhuley JN

    更新日期：1997-09-01 00:00:00

  • Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Plants from genus Lavandula have been used as anti-inflammatory drugs in Mediterranean traditional medicine. Nowadays, there is a growing interest for complementary medicine, including herbal remedies, to treat inflammatory bowel disease (IBD). AIM OF THE STUDY:To test the anti-inflammat...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.05.063

    authors： Algieri F,Rodriguez-Nogales A,Vezza T,Garrido-Mesa J,Garrido-Mesa N,Utrilla MP,González-Tejero MR,Casares-Porcel M,Molero-Mesa J,Del Mar Contreras M,Segura-Carretero A,Pérez-Palacio J,Diaz C,Vergara N,Vicente F,Rodriguez-Ca

    更新日期：2016-08-22 00:00:00

  • Medicinal plants for gastrointestinal diseases among the Kuki-Chin ethnolinguistic groups across Bangladesh, India, and Myanmar: A comparative and network analysis study.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The Kuki-Chin is a composite ethnolinguistic group made up of many distinct groups and subgroups that are linked by a common history, culture, and population distribution in the Kuki-Chin region, shared geopolitically by Bangladesh, India, and Myanmar. This region is shown to be in a hots...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2019.112415

    authors： Ong HG,Kim YD

    更新日期：2020-04-06 00:00:00

  • Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:There are many plants of genus Piper which have been reported to induce antidepressant-like effects, Piper sarmentosum (PS) is one of them. PS is a Chinese herbal medicine and a traditional edible vegetable. MATERIALS AND METHODS:In the present study, the antidepressant-like effects of P...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.01.037

    authors： Li Q,Qu FL,Gao Y,Jiang YP,Rahman K,Lee KH,Han T,Qin LP

    更新日期：2017-03-06 00:00:00

  • In vitro anti-glycation activity of the marine plant Posidonia oceanica (L.) Delile.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The marine plant Posidonia oceanica (L.) Delile is traditionally used by villagers of the west coast of Anatolia as a remedy for diabetes and hypertension. AIM OF THE STUDY:The aim of this study was to explore the role of the P. oceanica hydroalcoholic leaves extract (POE) against human ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112960

    authors： Vasarri M,Barletta E,Ramazzotti M,Degl'Innocenti D

    更新日期：2020-09-15 00:00:00

  • Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Synadenium grantii Hook f. has traditionally been used to treat various neoplastic diseases in southern Brazil. AIM OF STUDY:Evaluation of the antitumoural potential of Synadenium grantii latex against B16F10 melanoma cell line using in vitro and in vivo models, as well as a phytochemica...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.08.033

    authors： de Oliveira TL,Munhoz AC,Lemes BM,Minozzo BR,Nepel A,Barison A,Fávero GM,Campagnoli EB,Beltrame FL

    更新日期：2013-10-28 00:00:00

  • Anti-nociceptive activity of aqueous fraction from the MeOH extracts of Paederia scandens in mice.

    abstract：AIM OF THE STUDY:We examined the effects of the aqueous fraction (AF) on nociception models mice induced by the chemical and the thermal stimuli so as to elucidate the analgesic activity and provide scientific basis for the clinical use of Paederia scandens. MATERIALS AND METHODS:The AF of MeOH extract from P. scanden...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.03.011

    authors： Chu C,Huang Y,Chen YF,Wu JH,Rahman K,Zheng HC,Qin LP

    更新日期：2008-06-19 00:00:00

  • Effects of magnolialide isolated from the leaves of Laurus nobilis L. (Lauraceae) on immunoglobulin E-mediated type I hypersensitivity in vitro.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Laurus nobilis L. (Lauraceae) has been used for folk medicines in the Mediterranean area and Europe to treat various disorders including skin inflammation (dermatitis) and asthma. AIM OF THE STUDY:Our aim was to investigate the scientific evaluation of the compounds from Laurus nobilis L...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.07.015

    authors： Lee T,Lee S,Ho Kim K,Oh KB,Shin J,Mar W

    更新日期：2013-09-16 00:00:00

  • Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice.

    abstract：:Trigonella foenum-graecum (Fenugreek) (Leguminosae) is employed as a herbal medicine. Its seeds are known for their carminative, tonic and antidiabetic effects. A curative dose of Trigonella foenum-graecum also produces antiulcer action. In this study we have investigated the hypoglycaemic activities of the aqueous ex...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(01)00186-6

    authors： Zia T,Hasnain SN,Hasan SK

    更新日期：2001-05-01 00:00:00

  • Flourensia fiebrigii S.F. blake: A medicinal plant from the Argentinean highlands with potential use as anti-rheumatic and anti-inflammatory.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Flourensia fiebrigii is a plant used in traditional medicine in the Argentine Calchaquí Valley as purgative, expectorant, anti-rheumatic and anti-inflammatory. AIM OF THE STUDY:The aim of this study was to analyze the macroscopic and microscopic characteristics of F. fiebrigii leaf and s...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113296

    authors： Leal M,Zampini IC,Mercado MI,Moreno MA,Simirgiotis MJ,Bórquez J,Ponessa G,Isla MI

    更新日期：2021-01-10 00:00:00

  • The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice.

    abstract：:This study investigates anticonvulsant effects of an essential oil of the fruits of Pimpinella anisum (Umbelliferae), a folkloric remedy in the Iranian traditional medicine, against seizures induced by pentylenetetrazole (PTZ) or maximal electroshock (MES) in male mice. The essential oil suppressed tonic convulsions i...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(98)00161-5

    authors： Pourgholami MH,Majzoob S,Javadi M,Kamalinejad M,Fanaee GH,Sayyah M

    更新日期：1999-08-01 00:00:00

  • The methanolic extract of Thymus praecox subsp. skorpilii var. skorpilii restores glucose homeostasis, ameliorates insulin resistance and improves pancreatic β-cell function on streptozotocin/nicotinamide-induced type 2 diabetic rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Thymus praecox subsp. skorpilii var. skorpilii (syn. Thymus praecox subsp. jankae (Celak.) Jalas) is consumed as a Turkish folk medicine for the treatment of spasm, sore throat and shortness of breath, also having strong antioxidant activity and the leaves of the plant have been utilized ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.10.028

    authors： Cam ME,Hazar-Yavuz AN,Yildiz S,Ertas B,Ayaz Adakul B,Taskin T,Alan S,Kabasakal L

    更新日期：2019-03-01 00:00:00

  • The use of community herbal monographs to facilitate registrations and authorisations of herbal medicinal products in the European Union 2004-2012.

    abstract：:The provisions for the simplified registration of traditional herbal medicinal products in the European Union were introduced by Directive 2004/24/EC amending Directive 2001/83/EC (Chapter 2a) in 2004. Since implementation in the European member states until December 2012 a total of 1015 registrations (traditional use...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.07.015

    authors： Peschel W

    更新日期：2014-12-02 00:00:00

  • Reconstruction of the inventory of materia medica used by members of the Jewish community of medieval Cairo according to prescriptions found in the Taylor-Schechter Genizah collection, Cambridge.

    abstract：:The Taylor-Schechter (T-S) collection at Cambridge University Library is the biggest of all Cairo Genizah collections in the world. The importance and the potential of research into the medical aspects of the Genizah documents were clear to researcher since the early 1960s. A few works have been published since, usual...

    journal_title：Journal of ethnopharmacology

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.jep.2006.06.005

    authors： Lev E,Amar Z

    更新日期：2006-12-06 00:00:00

  • Pharmacokinetics and comparative metabolic profiling of iridoid enriched fraction of Picrorhiza kurroa - An Ayurvedic Herb.

    abstract：ETHNO-PHARMACOLOGICAL RELEVANCE:Picrosides I, II and apocynin are the main active principles present in the roots and rhizomes of Picrorhiza kurroa Royle ex. Benth (Kutki). Ethno-medicinally, the plant is used for the treatment of liver, upper respiratory tract disorders and dyspepsia, since long in Ayurveda. AIM OF T...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.07.072

    authors： Zahiruddin S,Khan W,Nehra R,Alam MJ,Mallick MN,Parveen R,Ahmad S

    更新日期：2017-02-02 00:00:00

  • Improvement in mitochondrial function underlies the effects of ANNAO tablets on attenuating cerebral ischemia-reperfusion injuries.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:ANNAO tablets derive from Chinese classical prescriptions of Angong Niuhuang Pills with modified compositions, which have been singly or combined used for stoke associated neurological disorders. However the underlying mechanism is not yet well-defined, the present study investigated its ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112212

    authors： Zhang Y,Cao M,Wu Y,Wang J,Zheng J,Liu N,Yang N,Liu Y

    更新日期：2020-01-10 00:00:00

  • Aphrodisiac properties of Allium tuberosum seeds extract.

    abstract：AIM OF THE STUDY:In the present study, we examined the effect of Allium tuberosum seeds extract upon the expression of male rat sexual behavior, in order to know whether Allium tuberosum seeds extract possess aphrodisiac property. MATERIALS AND METHODS:The aphrodisiac activity of Allium tuberosum seeds n-BuOH extract ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.01.018

    authors： Guohua H,Yanhua L,Rengang M,Dongzhi W,Zhengzhi M,Hua Z

    更新日期：2009-04-21 00:00:00

  • Knowledge on plants used traditionally in the treatment of tuberculosis in Uganda.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Tuberculosis (TB) is one of the leading causes of morbidity and mortality globally. The disease is especially important because of increasing drug resistant strains and co infection with human immune virus (HIV) and acquired immune disease syndrome (AIDS). Because of this there is need to...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.12.020

    authors： Bunalema L,Obakiro S,Tabuti JR,Waako P

    更新日期：2014-02-03 00:00:00

  • Toxicological screening of traditional medicine Laghupatha (Cissampelos pareira) in experimental animals.

    abstract：:Laghupatha (Cissampelos pareira) a important medicinal plant in Indian traditional system of medicine and is widely used in many countries by different tribal. Despite the wide use of Cissampelos pareira in folk medicine, no study has been published in the scientific literature about its toxicological profile. In pres...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.12.008

    authors： Amresh G,Singh PN,Rao CV

    更新日期：2008-03-28 00:00:00

  • Regulatory effects of Codonopsis lanceolata on gene expression of GM-CSF in macrophage-like cells.

    abstract：AIM OF THE STUDY:We aimed to demonstrate ethnopharmacological role of Codonopsis lanceolata L., known to be used as a folk qi tonic herb to aid those who are weakened by blood loss or other injury in Korea, by examining the expressional level of hematopoietic cytokines. RESULTS:BuOH fraction strongly up-regulated mRNA...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.02.014

    authors： Byeon SE,Lee YG,Cho JY

    更新日期：2009-05-04 00:00:00

  • Immunomodulatory effects of Abnormal Savda Munsiq, a traditional Uighur medicine, on the combined stress mice.

    abstract：OBJECTIVE:To investigate the immunomodulatory effects of ASMq, a herbal preparation used in Traditional Uighur Medicine, on the combined stress mice. MATERIALS AND METHODS:The combined stress was induced on mice by application of the electric-foot shock in a cold-dry environment and three different doses of ASMq were ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.11.023

    authors： Amat N,Upur H,Ablimit A,Matsidik A,Yusup A,Kijjoa A

    更新日期：2009-02-25 00:00:00