Human articular chondrocytes suppress in vitro proliferation of anti-CD3 activated peripheral blood mononuclear cells.

abstract：:The cancer stem cell (CSC) model encompasses an advantageous paradigm that in recent decades provides a better elucidation for many important biological aspects of cancer initiation, progression, metastasis, and, more important, development of multidrug resistance (MDR). Such several other hematological malignancies a...

journal_title：Journal of cellular physiology

authors： Mihanfar A,Aghazadeh Attari J,Mohebbi I,Majidinia M,Kaviani M,Yousefi M,Yousefi B

更新日期：2019-04-01 00:00:00

abstract：:Tenascin-C, a six-armed extracellular matrix glycoprotein, is expressed in a temporally and spatially restricted pattern during carcinogenesis and invasion or metastasis of carcinoma cells in association with stromal-epithelial interactions. The human epidermoid carcinoma-derived cell lines, A431 and HEp-2, which do n...

journal_title：Journal of cellular physiology

authors： Sakai T,Ohta M,Furukawa Y,Saga Y,Aizawa S,Kawakatsu H,Saito M

更新日期：1995-10-01 00:00:00

abstract：:The epithelium-specific ETS (ESE)-1 transcription factor is induced in chondrocytes by interleukin-1beta (IL-1beta). We reported previously that early activation of EGR-1 by IL-1beta results in suppression of the proximal COL2A1 promoter activity by displacement of Sp1 from GC boxes. Here we report that ESE-1 is a pot...

journal_title：Journal of cellular physiology

authors： Peng H,Tan L,Osaki M,Zhan Y,Ijiri K,Tsuchimochi K,Otero M,Wang H,Choy BK,Grall FT,Gu X,Libermann TA,Oettgen P,Goldring MB

更新日期：2008-05-01 00:00:00

abstract：:Formation of human T lymphocyte colonies in semisolid medium from T lymphocyte colony-forming units (TL-CFUs) under stimulation of phytohemagglutinin (PHA) has been reported by several authors. These TL-CFUs were present in unsensitized lymphocyte populations. We report here that such TL-CFUs are capable of renewing t...

journal_title：Journal of cellular physiology

authors： Wu AM

更新日期：1983-10-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic immune-mediated inflammatory disease that affects both axial and peripheral skeletons as well as soft tissues. Recent investigations offer that disease pathogenesis is ascribed to a complex interplay of genetic, environmental, and immunological factors. Until now, there is no a...

journal_title：Journal of cellular physiology

authors： Mohammadi H,Hemmatzadeh M,Babaie F,Gowhari Shabgah A,Azizi G,Hosseini F,Majidi J,Baradaran B

更新日期：2018-08-01 00:00:00

abstract：:Hepatocyte growth factor (HGF)-induced tubulogenesis has been demonstrated with renal epithelial cell lines grown in collagen gels but not with primary cultured renal proximal tubular epithelial cells (RPTEs). We show that HGF selectively induces proliferation and branching morphogenesis of primary cultured rat RPTEs....

journal_title：Journal of cellular physiology

authors： Bowes RC 3rd,Lightfoot RT,Van De Water B,Stevens JL

更新日期：1999-07-01 00:00:00

abstract：:Clones of Chinese hamster ovary (CHO) cells were isolated by single-step selection for resistance to killing Concanavalin A (ConA) and certain cellular and membrane properties were examined. The ConA-resistant isolates were only about 2-fold more resistant than wild type cells to the selecting lectin, but exhibited pl...

journal_title：Journal of cellular physiology

authors： Cifone MA,Hynes RO,Baker RM

更新日期：1979-07-01 00:00:00

abstract：:This study sought to evaluate the prospective role exerted by vascular endothelial growth factor (VEGF) in the modulation of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) signalling pathways in the rabbit retina. To reach this aim, the anti-VEGF agents aflibercept and ranibizumab were used as ...

journal_title：Journal of cellular physiology

authors： Segatto M,Fico E,Gharbiya M,Rosso P,Carito V,Tirassa P,Plateroti R,Lambiase A

更新日期：2019-08-01 00:00:00

abstract：:It was the goal of this study to determine whether during long-term quiescence WI-38 cells gradually lose labile components which then need to be resynthesized before a stimulated cell can progress through G-1 and enter S. The metabolic and molecular status of WI-38 cells was systematically analyzed as they entered an...

journal_title：Journal of cellular physiology

authors： Owen TA,Carter R,Whitman MM,Soprano DR,Soprano KJ

更新日期：1990-01-01 00:00:00

abstract：:Diabetic retinopathy (DR) is the most common ocular complication caused by diabetes mellitus and is the main cause of visual impairment in working-age people. Reactive gliosis and pro-inflammatory cytokine production by Müller cells contribute to the progression of DR. Melatonin is a strong anti-inflammatory hormone, ...

journal_title：Journal of cellular physiology

authors： Tu Y,Zhu M,Wang Z,Wang K,Chen L,Liu W,Shi Q,Zhao Q,Sun Y,Wang X,Song E,Liu X

更新日期：2020-11-01 00:00:00

abstract：:Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), are incurable diseases characterized by progressive loss of cognitive or motor function, which construct a serious threat to the life quality of aging populations and their life spans. Apelin is an ...

journal_title：Journal of cellular physiology

authors： Luo H,Han L,Xu J

更新日期：2020-02-01 00:00:00

abstract：:Experiments were conducted to determine the extent and variability of collagen degradation in human fetal lung fibroblasts. Cells were incubated with [14C]proline, and degradation was measured by determining the hydroxy[14C]proline in a low molecular weight fraction relative to total hydroxy[14C]proline. Average (basa...

journal_title：Journal of cellular physiology

authors： Bienkowski RS

更新日期：1984-10-01 00:00:00

abstract：:Retinoic acid (RA) is known to induce differentiation in many cell systems. This induction is mediated by nuclear RA receptors (RARs), which act as transactivating factors belonging to the superfamily of steroid/thyroid nuclear receptors. In this study, effects of RA were studied in a mouse myogenic C2 cell line and i...

journal_title：Journal of cellular physiology

authors： Halevy O,Lerman O

更新日期：1993-03-01 00:00:00

abstract：:The roles of Sonic hedgehog (Shh) and Bone morphogenetic protein-2 (Bmp-2) in osteoblast differentiation were investigated using in vitro cell systems. Recombinant amino-terminal portion of SHH (rSHH-N) dose dependently stimulated ALP activity in C3H10T1/2 and MC3T3-E1 cells. rSHH-N induced expression of Osteocalcin m...

journal_title：Journal of cellular physiology

authors： Yuasa T,Kataoka H,Kinto N,Iwamoto M,Enomoto-Iwamoto M,Iemura S,Ueno N,Shibata Y,Kurosawa H,Yamaguchi A

更新日期：2002-11-01 00:00:00

abstract：:We determined the mitogenic and comitogenic properties of tumor promoters in the indole alkaloid series; agents that differ structurally from 12-0-tetradecanoylphorbol-13-acetate (TPA), which is known to be a lymphocyte mitogen. Teleocidin and dihydroteleocidin B were mitogenic for human lymphocytes, and lyngbyatoxin ...

journal_title：Journal of cellular physiology

authors： Novogrodsky A,Patya M,Fujiki H,Rubin AL,Stenzel KH

更新日期：1984-07-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal and disabling neurodegenerative disease characterized by upper and lower motor neurons depletion. In our previous work, comprehensive genomic profiling of 41 motor cortex samples enabled to discriminate controls from sporadic ALS patients, and segregated these latter into...

journal_title：Journal of cellular physiology

authors： Bonaventura G,Iemmolo R,D'Amico AG,La Cognata V,Costanzo E,Zappia M,D'Agata V,Conforti FL,Aronica E,Cavallaro S

更新日期：2018-04-01 00:00:00

abstract：:Numerous studies suggest that epidermal growth factor (EGF) signaling is impaired in nonproliferating senescent human diploid fibroblasts downstream of receptor binding. One possible explanation for these results is that senescent cells possess unique enzymatic activities capable of regulating functional levels of the...

journal_title：Journal of cellular physiology

authors： Carlin C,Phillips PD,Brooks-Frederich K,Knowles BB,Cristofalo VJ

更新日期：1994-09-01 00:00:00

abstract：:The protease nexins (PN-I, Mr approximately 38,000; PN-II, Mr approximately 95,000; and PN-III, Mr approximately 31,000) are recently described cell-secreted proteins that selectively link to regulatory serine proteases in the extracellular environment and mediate their cellular binding, internalization, and degradati...

journal_title：Journal of cellular physiology

authors： Knauer DJ,Thompson JA,Cunningham DD

更新日期：1983-12-01 00:00:00

abstract：:NEAT1 is an important tumor oncogenic gene in various tumors. Nevertheless, its involvement remains poorly studied in cervical cancer. Our study explored the functional mechanism of NEAT1 in cervical cancer. NEAT1 level in several cervical cancer cells was quantified and we found NEAT1 was greatly upregulated in vitro...

journal_title：Journal of cellular physiology

authors： Yuan LY,Zhou M,Lv H,Qin X,Zhou J,Mao X,Li X,Xu Y,Liu Y,Xing H

更新日期：2019-08-01 00:00:00

abstract：:alpha-Thrombin, bradykinin, and histamine are endogenous mediators that increase endothelial permeability. We examined the mechanism by which these three vasoactive mediators could alter permeability to albumin of human umbilical vein endothelial cells (HUVEC). HUVEC were grown to confluence on Transwell membranes and...

journal_title：Journal of cellular physiology

authors： Ehringer WD,Edwards MJ,Miller FN

更新日期：1996-06-01 00:00:00

abstract：:The role of microtubules in mitogen-induced human lymphocyte activation and proliferation was examined. The effect of colchicine, a microtubule-disrupting agent, was compared with taxol, a microtubule-stabilizing drug, and with isaxonine (N-isopropyl-amino-2-pyrimidine orthophosphate), a proposed microtubular-active d...

journal_title：Journal of cellular physiology

authors： Cuthbert JA,Shay JW

更新日期：1983-08-01 00:00:00

abstract：:Sprouting angiogenesis is a major form of neovascularization of tissues suffering from hypoxia and other related stress. Endothelial cells (ECs) undergo proliferation, differentiation, programmed death, and migration during angiogenic sprouting, but the underlying molecular mechanisms regulating ECs in angiogenesis ha...

journal_title：Journal of cellular physiology

authors： Liu Y,Zheng Q,He G,Zhang M,Yan X,Yang Z,Zhang P,Wang L,Liu J,Liang L,Han H

更新日期：2019-06-01 00:00:00

abstract：:As a natural metabolite of limonoids from Dictamnus dasycarpus, fraxinellone has been reported to be neuroprotective and anti-inflammatory. However, its influence on cellular metabolism remains largely unknown. In the present study, we investigated the effect of fraxinellone on cellular senescence-induced by oxidative...

journal_title：Journal of cellular physiology

authors： Han X,Chen H,Zhou J,Tai H,Gong H,Wang X,Huang N,Qin J,Fang T,Wang F,Xiao H

更新日期：2018-05-01 00:00:00

abstract：:The Schneider membrane is the mucosa that covers the inner part of the maxillary sinus cavities. The free surface is a ciliated pseudostratified epithelium, while the deeper portion is a highly vascularized connective tissue. The stromal fraction, bordering the bony wall of the sinus, after tooth loss can exhibit incr...

journal_title：Journal of cellular physiology

authors： Graziano A,Benedetti L,Massei G,Cusella de Angelis MG,Ferrarotti F,Aimetti M

更新日期：2012-09-01 00:00:00

abstract：:Although the mechanism is unknown, infiltration anesthetics are believed to have membrane-stabilizing action. We report here that such a most commonly used anesthetic, lidocaine, effectively inhibited the invasive ability of human cancer (HT1080, HOS, and RPMI-7951) cells at concentrations used in surgical operations ...

journal_title：Journal of cellular physiology

authors： Mammoto T,Higashiyama S,Mukai M,Mammoto A,Ayaki M,Mashimo T,Hayashi Y,Kishi Y,Nakamura H,Akedo H

更新日期：2002-09-01 00:00:00

abstract：:The concentration of ATP in cysts of the brine shrimp, Artemia salina, has been studied as a function of cyst hydration. Cysts dried over CaSO4 contain 0.02 gH2O/g cysts and 0.54 +/- 0.05 (S.D.) mumoles of ATP/g dried cysts. Addition of water up to 0.05 g/g cysts produced no net change in the level of ATP during incub...

journal_title：Journal of cellular physiology

authors： Clegg JS,Cavagnaro J

更新日期：1976-06-01 00:00:00

abstract：:We investigated the role of mammalian target of rapamycin/nuclear factor-kappa B (mTOR/NF-κB) signaling pathway in high thoracic epidural anesthesia (HTEA) against myocardial ischemia-reperfusion (I/R) injury in rats. The rat model of myocardial I/R injury was established. Ninety rats were divided into the normal, sha...

journal_title：Journal of cellular physiology

authors： Huang WQ,Wen JL,Lin RQ,Wei P,Huang F

更新日期：2018-09-01 00:00:00

abstract：:The unique vascular supply of the retina, the ability to visualize the vasculature in vivo, and the ability to selectively express genes in the retina make the retina an ideal model system to study molecular mechanisms of angiogenesis. In addition, this area of investigation has great clinical significance, because re...

journal_title：Journal of cellular physiology

authors： Campochiaro PA

更新日期：2000-09-01 00:00:00

abstract：:The mechanisms of agonist-induced calcium entry (ACE) following depletion of intracellular calcium stores have not been fully established. We report here that calcium-independent phospholipase A (iPLA(2)) is required for robust Ca(2+) entry in HaCaT keratinocytes following ATP or UTP stimulation. Lysophosphatidic acid...

journal_title：Journal of cellular physiology

authors： Ross K,Whitaker M,Reynolds NJ

更新日期：2007-06-01 00:00:00

abstract：:During human pregnancy, the trophoblast develops from differentiation of cytotrophoblast cells into an endocrine active syncytiotrophoblast. In culture, isolated mononuclear cytotrophoblasts aggregate and then fuse to form a syncytium, reproducing the in vivo process. In this study, we examined the effect of low oxyge...

journal_title：Journal of cellular physiology

authors： Alsat E,Wyplosz P,Malassiné A,Guibourdenche J,Porquet D,Nessmann C,Evain-Brion D

更新日期：1996-08-01 00:00:00