Cellular magnetic resonance imaging: current status and future prospects.

Abstract:

:Cellular magnetic resonance imaging (CMRI) allows for the tracking of the temporal and spatial migration of cells labeled with MR contrast agents within organs and tissues. This rapidly growing area of experimental research has the potential of translating from bench to bedside and may be used in conjunction with cellular therapy clinical trials or in the evaluation of novel drug therapies. Ex vivo labeling of nonphagocytic cells with superparamagnetic iron oxide nanoparticles or paramagnetic contrast agents (i.e., gadolinium or manganese) allows for the detection of single cells or clusters of labeled cells within target tissues using CMRI following either direct implantation or intravenous injection. However, prior to the translation of experimental cell labeling studies to clinical trials, it is essential to perform preclinical evaluation to demonstrate a lack of toxicity, the ability to scale-up labeling using good manufacturing practice and the ability to detect cells by in vivo MRI in relevant model systems.

journal_name

Expert Rev Med Devices

authors

Arbab AS,Liu W,Frank JA

doi

10.1586/17434440.3.4.427

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

427-39

issue

4

eissn

1743-4440

issn

1745-2422

journal_volume

3

pub_type

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