Abstract:
:Neurodegeneration in Parkinson's disease (PD) affects both the fine motor control of the fingers and gross movement of the upper limb. Handwriting examinations are commonly performed in the analysis of tremor in PD and there is validity in subjective assessment in the clinic. However, there is clinical need for a more objective assessment instrument to assist in diagnosis. The Manus platform is a novel sensor system with automated mathematical methods, integrated with a digital pen, for differential diagnosis of PD that allows an objective assessment of handwriting. Our team are starting a clinical trial to assess the clinical usefulness of the system for differential diagnosis. The ability of the system to diagnose PD will be validated against the current best practice diagnosis of clinical opinion (or dopamine transporter imaging scan (DaTSCAN) imaging when an unequivocal diagnosis cannot be made). If the study proves clinically successful, the system may find application in clinics to aid in differentiating between impairments and be a low-cost alternative to DaTSCAN that can be operated with minimal training and is acceptable to patients.
journal_name
Expert Rev Med Devicesjournal_title
Expert review of medical devicesauthors
Walker RW,Zietsma R,Gray WKdoi
10.1586/17434440.2014.900437subject
Has Abstractpub_date
2014-05-01 00:00:00pages
243-5issue
3eissn
1743-4440issn
1745-2422journal_volume
11pub_type
社论,评审abstract:INTRODUCTION:Funding for scientific advancement comes from two dominant sources: public funds used to generate knowledge, and private sector funds in the pursuit of commercial products. It is unclear how to compare the outputs of these two financial mechanisms because both sectors are motivated by common goods but are ...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1080/17434440.2018.1419866
更新日期:2018-02-01 00:00:00
abstract::This article investigates various neural machine interfaces for voluntary control of externally powered upper-limb prostheses. Epidemiology of upper limb amputation, as well as prescription and follow-up studies of externally powered upper-limb prostheses are discussed. The use of electromyographic interfaces and peri...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.4.1.43
更新日期:2007-01-01 00:00:00
abstract::A wearable and, ultimately, an implantable artificial kidney is a long-held aim in the treatment of patients with end-stage renal disease, provided that it would combine continuous blood purification, preventing the fluctuations in the internal environment associated with hemodialysis, while maintaining a high efficie...
journal_title:Expert review of medical devices
pub_type: 社论
doi:10.1586/17434440.2015.1053466
更新日期:2015-07-01 00:00:00
abstract::Acute ischemic stroke is caused by occlusion of a cerebral artery, resulting in loss of brain tissue and neurologic deficits. However, a portion of the ischemic brain can be salvaged if blood flow is restored within an appropriate time frame. The past year has seen the publication of five positive randomized controlle...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2016.1143772
更新日期:2016-01-01 00:00:00
abstract::Despite advances in our understanding of surgical site infections following total joint arthroplasty, this serious surgical complication continues to represent a substantial economic burden for the patient, the treating institution and the healthcare system. After increasing for the past decade, infection rates have s...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.12.76
更新日期:2013-03-01 00:00:00
abstract::Introduction: The increasing complexity of patients undergoing percutaneous coronary intervention (PCI) regarding both coronary anatomy and comorbidities requires dedicated devices. The Resolute Onyx (R-Onyx, Medtronic, CA, USA) stent is a novel durable polymer zotarolimus-eluting stent (ZES) promising better delivera...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2020.1736037
更新日期:2020-04-01 00:00:00
abstract::To obtain data for maternal stroke volume and cardiac output during pregnancy, it is preferable to use a non-invasive, accurate and reproducible method. In this aspect, impedance cardiography is an excellent technique which is also highly accessible and easy to perform. This paper is a comprehensive review on the publ...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2013.853466
更新日期:2013-11-01 00:00:00
abstract::Temperature analysis has been considered as a complementary method in medical evaluation and diagnosis. Several studies demonstrated that monitoring the temperature variations of the feet of diabetic patients can be helpful in the early identification of diabetic foot manifestations, and also in changing behaviors, wh...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2015.1032251
更新日期:2015-07-01 00:00:00
abstract:INTRODUCTION:Refinements in endovascular technology have revolutionized the treatment of intracranial aneurysms (IAs) with the development of flow-diversion technology. The first generation of the Pipelin Embolization Device (PED) has demonstrated its safety and efficacy. However, the deployment technique was a difficu...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1080/17434440.2016.1231573
更新日期:2016-10-01 00:00:00
abstract::The introduction of retrievable inferior vena cava (IVC) filters was an important step in the evolution of deep vein thrombosis/pulmonary embolism management. Their removability makes them preferred to permanent filters in many cases. IVC filter retrieval often occurs at a suboptimal rate, leading to complications ass...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.12.65
更新日期:2013-01-01 00:00:00
abstract::Infections related to electrophysiologic cardiac device placement are increasing dramatically and are associated with adverse outcomes. With the US population aging and living longer, cardiac devices are utilized in an older population with significant comorbidities, making the threat from infectious complications sig...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.5.2.183
更新日期:2008-03-01 00:00:00
abstract::Ventricular assist devices (VAD) are used for mechanical support of the terminally failing heart. Failure of these life supporting systems can be fatal. Early and reliable detection of any upcoming problems is mandatory and is crucial for the outcome. Medical imaging methods are described within this review, which are...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2016.1166051
更新日期:2016-05-01 00:00:00
abstract:INTRODUCTION:Introduction: Transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are noninvasive neuromodulation techniques used as therapeutic and research tools for several neuropsychiatric conditions. Given the exponential scientific growth of this field, we aimed to systematical...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2019.1615440
更新日期:2019-06-01 00:00:00
abstract::The combination of T2-weighted MRI with functional MRI, including contrast-enhanced MRI, diffusion-weighted imaging and magnetic resonance spectroscopy, has been recognized as the most promising diagnostic modality for the detection and staging of localized prostate cancer. In spite of the relatively low predictive va...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.10.24
更新日期:2010-07-01 00:00:00
abstract::Malignant biliary obstruction results in jaundice, often with symptoms that decrease the quality of life. Biliary stent placement has largely supplanted surgical bypass for palliation of malignant biliary obstruction. Traditional rigid plastic stents are commonly used, inexpensive and easily removed, although with lim...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.10.36
更新日期:2010-09-01 00:00:00
abstract::Powered instruments have been introduced into otorhinolaryngology practice over the last decade. These instruments were accepted immediately by many institutions, and continuing development has led to the current use of microdebriders in a variety of surgical procedures in otorhinolaryngology. In clinical rhinology, t...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.10.7
更新日期:2010-05-01 00:00:00
abstract::Drug eluting stents and particularly the fully bioresorbable drug-eluting scaffolds herald a new era in percutaneous treatment of coronary artery disease. There has been tremendous progress in drug eluting stents with fully biodegradable coating polymers and polymer-free devices with reservoir technology planting the ...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2016.1143356
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Since the advent of peritoneal dialysis (PD) in the 1970s, the principles of dialysis have changed little. In the coming decades, several major breakthroughs are expected. AREAS COVERED:Novel wearable and portable dialysis devices for both hemodialysis (HD) and PD are expected first. The HD devices could ...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2018.1462697
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:Coronary artery disease affecting myocardial perfusion continues to be the leading cause of cardiovascular morbidity and mortality worldwide. While invasive evaluation based on coronary angiography and flow measurements still is considered the reference technique for assessing myocardial perfusion, technol...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2020.1834844
更新日期:2020-11-01 00:00:00
abstract::Introduction: Catheter directed interventions (CDIs) have evolved over the past decade in an attempt to reduce the complications of systemic thrombolysis, while providing equivalent therapeutic benefits.Areas covered: CDIs include a wide array of catheters that incorporate ultrasound technology, the infusion of thromb...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2020.1714432
更新日期:2020-02-01 00:00:00
abstract::Although implanted for over 40 years, finger prostheses have failed to match the success achieved by artificial hip and knee prostheses, despite a myriad of designs having been proposed and implanted. This article looks at the currently available designs of metacarpophalangeal prosthesis, both single-piece and multico...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.1.2.193
更新日期:2004-11-01 00:00:00
abstract::This article focuses on the surface engineering of ventricular assist devices (VADs) for the treatment of heart failure patients, which involves the modification of surfaces contacting blood in order to improve the blood compatibility (hemocompatibility) of the VADs. Following an introduction to the categorization and...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.6.1.51
更新日期:2009-01-01 00:00:00
abstract::An increasing number of disease-causing bacteria are resistant to one or more anti-bacterial drugs utilized for therapy. Early and speedy detection of these pathogens is therefore very important. Traditional pathogen detection techniques, that include microbiological and biochemical assays are long and labor-intensive...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2014.882767
更新日期:2014-03-01 00:00:00
abstract::With advances in endoscopic imaging tools, it is becoming increasingly possible to find, assess and treat numerous gastrointestinal (GI) pathologies at the time of endoscopy. This article focuses on the newly developed Pentax confocal endomicroscope that enables in vivo microscopic imaging of the upper and lower GI tr...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1586/17434440.3.5.549
更新日期:2006-09-01 00:00:00
abstract::The US FDA recognizes that there are many challenges to ensuring that medical devices are used responsibly and safely in the pediatric population. Education plays a key role, and manufacturers and healthcare providers must be informed of medical device issues unique to the pediatric population. Healthcare workers and ...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1586/17434440.6.2.131
更新日期:2009-03-01 00:00:00
abstract::Glaucoma is a leading cause of blindness worldwide. Currently, topical drops are the mainstay of treatment for patients who suffer from this chronic disease. Adherence to topical therapy is known to be affected by forgetfulness, frequent dosing requirements and physical limitations. Dosing and adherence aids are desig...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.4.2.261
更新日期:2007-03-01 00:00:00
abstract::Conventional ultrasonography represents the first diagnostic imaging modality for the study of pancreatic tumors. Contrast-enhanced ultrasound has significantly improved the accuracy of first-line examination and may influence the choice of second-line investigations: multidetector computed tomography is considered th...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.09.67
更新日期:2010-03-01 00:00:00
abstract::Autofluorescence imaging videobronchoscopy (AFI) is one of the new systems of autofluorescence bronchoscopy designed for thorough examination of bronchial mucosa. The integration of autofluorescence and videobronchoscopy provides clear images of normal and pathologically altered bronchial mucosa. Major indications for...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1586/erd.10.92
更新日期:2011-03-01 00:00:00
abstract::Laparoscopic techniques represent a key milestone in the development of modern surgery, offering a step change in quality of care, patient satisfaction and efficiency in use of health service resources. Laparoscopy is most widely used for gall bladder surgery. As would be expected with the introduction of any new tech...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.11.43
更新日期:2011-09-01 00:00:00
abstract::Clinical applications in the developing world, such as malaria and anemia diagnosis, demand a change in the medical paradigm of expensive care given in central locations by highly trained professionals. There has been a recent explosion in optical technologies entering the consumer market through the widespread adopti...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2015.1075388
更新日期:2015-01-01 00:00:00