Abstract:
:APDM's Mobility Lab system provides portable, validated, reliable, objective measures of balance and gait that are sensitive to Parkinson's disease (PD). In this review, we describe the potential of objective measures collected with the Mobility Lab system for tracking longitudinal progression of PD. Balance and gait are among the most important motor impairments influencing quality of life for people with PD. Mobility Lab uses body-worn, Opal sensors on the legs, trunk and arms during prescribed tasks, such as the instrumented Get Up and Go test or quiet stance, to quickly quantify the quality of balance and gait in the clinical environment. The same Opal sensors can be sent home with patients to continuously monitor the quality of their daily activities. Objective measures have the potential to monitor progression of mobility impairments in PD throughout its course to improve patient care and accelerate clinical trials.
journal_name
Expert Rev Med Devicesjournal_title
Expert review of medical devicesauthors
Mancini M,Horak FBdoi
10.1586/17434440.2016.1153421subject
Has Abstractpub_date
2016-05-01 00:00:00pages
455-62issue
5eissn
1743-4440issn
1745-2422journal_volume
13pub_type
杂志文章,评审abstract::Temperature analysis has been considered as a complementary method in medical evaluation and diagnosis. Several studies demonstrated that monitoring the temperature variations of the feet of diabetic patients can be helpful in the early identification of diabetic foot manifestations, and also in changing behaviors, wh...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2015.1032251
更新日期:2015-07-01 00:00:00
abstract::Left atrial appendage device occlusion for the preventions of systemic thromboembolism and stroke represents a major breakthrough in the field of cardiovascular disease. The wide prevalence of atrial fibrillation with devastating consequences of thromboembolic stroke as a result of thrombus arising from the left atria...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2014.940315
更新日期:2014-11-01 00:00:00
abstract::Introduction: Potential complications associated with screw malposition may result in neurological deficits or vascular injuries. Spine surgery has significantly developed under the assistance of technological progress. The advantages of applying robotic technology in spine surgery include the possibility of improving...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2020.1699405
更新日期:2020-01-01 00:00:00
abstract::Cardiac resynchronization therapy (CRT) is a proven treatment adjunct for selected patients with heart failure and evidence of ventricular dyssynchrony. When applying most contemporary guidelines the accepted response rate has remained static with up to one-third of patients failing to respond. Empiric lateral/postero...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2014.885320
更新日期:2014-05-01 00:00:00
abstract::An increasing number of disease-causing bacteria are resistant to one or more anti-bacterial drugs utilized for therapy. Early and speedy detection of these pathogens is therefore very important. Traditional pathogen detection techniques, that include microbiological and biochemical assays are long and labor-intensive...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2014.882767
更新日期:2014-03-01 00:00:00
abstract::Infections related to electrophysiologic cardiac device placement are increasing dramatically and are associated with adverse outcomes. With the US population aging and living longer, cardiac devices are utilized in an older population with significant comorbidities, making the threat from infectious complications sig...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.5.2.183
更新日期:2008-03-01 00:00:00
abstract::This article reviews the current status of cochlear implantation in both adults and children, including expanding candidacy groups, bilateral implantation, advances in speech processing software, internal and external device hardware, surgical techniques and outcomes. Promising advances, novel therapies and evolving c...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.11.12
更新日期:2011-05-01 00:00:00
abstract::Vitreoretinal surgery has recently undergone remarkable developments. The introduction of micro-incision vitrectomy surgery using 25- and 23-gauge techniques has led to minimally invasive, faster, safer, and more accurate surgeries. Similarly, intraocular illumination and observation systems have advanced from light p...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2014.882226
更新日期:2014-03-01 00:00:00
abstract::Precise and accurate biomechanical reconstruction during total hip arthroplasty (THA) is essential for durable long-term survivorship. Accurate fit of cementless hip implants is also crucial to reduce micromotion between the bone-implant interfaces to allow for stable osseointegration. Robotic technology aims to minim...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2016.1124018
更新日期:2016-01-01 00:00:00
abstract::Neurodegeneration in Parkinson's disease (PD) affects both the fine motor control of the fingers and gross movement of the upper limb. Handwriting examinations are commonly performed in the analysis of tremor in PD and there is validity in subjective assessment in the clinic. However, there is clinical need for a more...
journal_title:Expert review of medical devices
pub_type: 社论,评审
doi:10.1586/17434440.2014.900437
更新日期:2014-05-01 00:00:00
abstract::MRI is the gold standard diagnostic tool for soft tissue imaging for many specialties. An impressive body of research has proven the effectiveness of cardiac rhythm management devices (CRMDs) objectively, in terms of parameters that include patient's quality of life, morbidity, and mortality. However, interaction betw...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2014.882228
更新日期:2014-03-01 00:00:00
abstract::A wearable and, ultimately, an implantable artificial kidney is a long-held aim in the treatment of patients with end-stage renal disease, provided that it would combine continuous blood purification, preventing the fluctuations in the internal environment associated with hemodialysis, while maintaining a high efficie...
journal_title:Expert review of medical devices
pub_type: 社论
doi:10.1586/17434440.2015.1053466
更新日期:2015-07-01 00:00:00
abstract::Future viral outbreaks are a major threat to societal and economic development throughout the world. A rapid, sensitive and easy-to-use test for viral infections is essential to prevent and control such viral pandemics. Furthermore, a compact, portable device is potentially very useful in remote or developing regions ...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1586/17434440.4.4.447
更新日期:2007-07-01 00:00:00
abstract:INTRODUCTION:Decreasing radiation exposure of the cardiac catheterization laboratory staff is critical for minimizing radiation-related adverse outcomes and can be accomplished by decreasing patient dose and by shielding. Areas covered: protection from ionizing radiation can be achieved with architectural, equipment-mo...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2018.1510771
更新日期:2018-09-01 00:00:00
abstract::Diabetic retinopathy (DR) is a common complication of diabetes. DR obstructs blood supply to the retina and has serious and long-lasting detrimental effects on quality of life. Panretinal photocoagulation, a laser surgical intervention, is advocated for early treatment of DR to prevent visual loss; however, results fr...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2014.953057
更新日期:2015-01-01 00:00:00
abstract::Background: Saline is not biocompatible with saphenous vein grafts and does not protect against ischemia reperfusion injury. We compared normal heparinized saline with DuraGraft, a new graft-storage solution, in in-vitro and ex-vivo assays to evaluate the effects on cells and vascular graft tissue.Methods: Human saphe...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1080/17434440.2019.1682996
更新日期:2019-11-01 00:00:00
abstract:INTRODUCTION:Mechanical circulatory support (MCS) is an increasingly utilized mode of therapy in the management of advanced heart failure, both as bridge to heart transplantation and destination therapy. As MCS becomes more prevalent, it is ever more important to understand the complex hemodynamics of these devices, as...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2017.1324292
更新日期:2017-05-01 00:00:00
abstract::This paper discusses a new class of robots known as concentric tube robots and their application to transnasal skull base surgery. The endonasal approach has clear benefits for patients, but the surgery presents challenges that strongly motivate the use of robotic tools. In this paper, the concentric tube robot concep...
journal_title:Expert review of medical devices
pub_type: 社论
doi:10.1586/17434440.2013.854702
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Funding for scientific advancement comes from two dominant sources: public funds used to generate knowledge, and private sector funds in the pursuit of commercial products. It is unclear how to compare the outputs of these two financial mechanisms because both sectors are motivated by common goods but are ...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1080/17434440.2018.1419866
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION:Transcatheter devices have contributed significantly to the advances achieved in treating many cardiovascular conditions over the last few decades. Sophisticated and detailed preclinical testing is not only a regulatory requirement to support an investigational device exemption (IDE) application, but more ...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1080/17434440.2017.1282313
更新日期:2017-02-01 00:00:00
abstract::Ureteral stents are used in a variety of urological diseases and procedures. The majority of patients with indwelling ureteral stents experience bothersome symptoms and are at increased risk for urinary tract infection. Stent encrustation and the associated complications can also result in significant patient morbidit...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.3.3.395
更新日期:2006-05-01 00:00:00
abstract::This article investigates various neural machine interfaces for voluntary control of externally powered upper-limb prostheses. Epidemiology of upper limb amputation, as well as prescription and follow-up studies of externally powered upper-limb prostheses are discussed. The use of electromyographic interfaces and peri...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.4.1.43
更新日期:2007-01-01 00:00:00
abstract::Although implanted for over 40 years, finger prostheses have failed to match the success achieved by artificial hip and knee prostheses, despite a myriad of designs having been proposed and implanted. This article looks at the currently available designs of metacarpophalangeal prosthesis, both single-piece and multico...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.1.2.193
更新日期:2004-11-01 00:00:00
abstract::Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) that are mechanical/physical, chemical and biological/molecular DDS. In this paper, we report on the recent advances in site-specific drug delivery (site-specific, controlled, targeted or smart drug d...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2015.1091722
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Recurrent unexplained syncope is a well-established indication for an insertable cardiac monitor (ICM). Recently, the indications for an ICM have been expanded. AREAS COVERED:This review article discusses the current indications for ICMs and gives an overview of the latest generation of commercially avail...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2018.1557046
更新日期:2019-01-01 00:00:00
abstract::Introduction: Catheter directed interventions (CDIs) have evolved over the past decade in an attempt to reduce the complications of systemic thrombolysis, while providing equivalent therapeutic benefits.Areas covered: CDIs include a wide array of catheters that incorporate ultrasound technology, the infusion of thromb...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1080/17434440.2020.1714432
更新日期:2020-02-01 00:00:00
abstract::To reduce the toxic effects, related clinical problems and complications such as bleeding disorders associated with systemic anticoagulation, it has been hypothesized that by coating the surfaces of medical devices, such as stents, bypass grafts, extracorporeal circuits, guide wires and catheters, there will be a sign...
journal_title:Expert review of medical devices
pub_type: 杂志文章
doi:10.1586/17434440.3.2.245
更新日期:2006-03-01 00:00:00
abstract:INTRODUCTION:Anastomotic leak (AL) after colorectal surgery is a devastating complication; decreased blood perfusion is an important risk factor. Surgeons rely on subjective measures to assess bowel perfusion. Fluorescence imaging (FI) with indocyanine green (ICG) provides a real-time objective assessment of intestinal...
journal_title:Expert review of medical devices
pub_type: 杂志文章,meta分析,评审
doi:10.1080/17434440.2017.1265444
更新日期:2017-01-01 00:00:00
abstract::In the last 30 years, development of minimally invasive percutaneous procedures to treat cardiovascular defects has been thriving. Although these techniques present obvious advantages, like avoiding cardiopulmonary bypass, the passage of catheter systems and the deployment of devices in the blood circulation can cause...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/17434440.2015.1120666
更新日期:2016-01-01 00:00:00
abstract::The surgical implantation of auditory devices to improve or restore the sensation of hearing in affected individuals is a rapidly growing area of modern ear, nose and throat, and audiological practice. Following the enormous success of cochlear implantation and set to take an increasing role in the rehabilitation of d...
journal_title:Expert review of medical devices
pub_type: 杂志文章,评审
doi:10.1586/erd.11.18
更新日期:2011-07-01 00:00:00