Abstract:
PRINCIPLES:3435C>T, a single nucleotide polymorphism (SNP) in exon 26 of the MDR1 gene, is linked to the variability of P-gp expression and function among different individuals. It was found that ethnic differences exist in the polymorphism of the MDR1(C3435T) gene. However, the distribution of 3435C>T genotypes in the Chinese Han population is not clear up till now. METHODS:In this study, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess 3435C>T genotypes in 265 healthy individuals of the Han population of China. RESULTS:The genotype frequencies were: CC 32% (n = 85), CT 48% (n = 127) and TT 20% (n = 53). C and T allele frequencies were 0.56 and 0.44 respectively. The C allelic frequency for female was 56.5% (T: 43.5%), and 55.9% (T: 44.1%) for male. CONCLUSIONS:There was no significant difference between females and males (p = 0.92, OR = 1.02, 95%CI: 0.67-1.57) in the present study. The frequency of C-allele was similar to that of some populations in Asia/Europe and was lower than that of populations in Africa. When compared with the study on Singapore-Chinese, some differences were found. The results of this study would be useful for individualised therapy of some diseases, and could have a prognostic implication for the Chinese Han population.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Li Y,Wang Y,Sun J,Li Y,Yang Ldoi
2006/23/smw-11113subject
Has Abstractpub_date
2006-06-10 00:00:00pages
377-82issue
23-24eissn
1424-7860issn
1424-3997pii
smw-11113journal_volume
136pub_type
杂志文章abstract::Antiosteoporotic drugs are recommended in patients with fragility fractures and in patients considered to be at high fracture risk on the basis of clinical risk factors and/or low bone mineral density. As first-line treatment most patients are started with an antiresorptive treatment, i.e. drugs that inhibit osteoclas...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14484
更新日期:2017-08-16 00:00:00
abstract:BACKGROUND:The European Consensus Statement of Neonatal Hearing recommended universal newborn hearing screening (UNHS) in 1998. UNHS was introduced in Switzerland in 1999 under the auspices of a "Swiss Working Group Hearing Screening in Newborns". The aim of this study was to evaluate the number of newborns being scree...
journal_title:Swiss medical weekly
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更新日期:2013-12-13 00:00:00
abstract:AIM:To test the hypothesis that rationing of medical management mainly based on age exists in our health care system today. METHODS:We studied 303 consecutive patients hospitalised for acute coronary syndrome (ACS) and 163 consecutive patients hospitalised with congestive heart failure (CHF). They were divided into tw...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2001/43/smw-09823
更新日期:2001-11-10 00:00:00
abstract:OBJECTIVES AND METHODS:Gender differences regarding 17 childhood experiences, thought to have traumatising potential (Traumatic Childhood Experiences = TCE), and pain behaviour in adulthood were assessed using a self-administered, anonymously filled-out questionnaire. Patients were consecutively accrued in the offices ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2006/39/smw-11357
更新日期:2006-09-30 00:00:00
abstract:QUESTIONS UNDER STUDY:Teenage and young adult (TYA) cancer patients are faced with the diagnosis during a challenging period of psychosocial development that may affect social outcomes in the long term. Therefore, we aimed to: (1) determine differences in social outcomes between long-term TYA cancer survivors and healt...
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更新日期:2017-03-07 00:00:00
abstract:BACKGROUND:Evaluating the effects of a commercially available synbiotic preparation (contains both prebiotic and probiotic elements) on functional constipation in males. METHODS:In a randomised controlled trial, a total of 66 adult men with functional constipation were equally allocated to receive a synbiotic mixture ...
journal_title:Swiss medical weekly
pub_type: 杂志文章,随机对照试验
doi:10.4414/smw.2011.13239
更新日期:2011-07-30 00:00:00
abstract:BACKGROUND:Adverse reactions to nonsteroidal antiinflammatory drugs (NSAIDs) are frequently reported, particularly among asthmatic patients. To date, there is no causal treatment available apart from tolerance induction. Therefore, the search for safe alternative drugs is of pivotal importance in clinical practice. OB...
journal_title:Swiss medical weekly
pub_type: 临床试验,杂志文章
doi:2006/43/smw-11358
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abstract:UNLABELLED:In an earlier study in 2002 we showed that of 101 persons applying for a disability pension for psychiatric reasons, a psychiatric diagnosis that affected their ability to work, could only be confirmed in 83%. Furthermore, and even more importantly, only 64% of these cases were receiving any psychiatric trea...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2008/23/smw-12102
更新日期:2008-06-14 00:00:00
abstract::Over the last few years atypical antipsychotics have been used increasingly in the pharmacological treatment of schizophrenia. This review provides an overview of the pharmacological and clinical characteristics of atypical antipsychotics. In particular we discuss their efficacy in treating psychotic and negative symp...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2003/05/smw-10003
更新日期:2003-02-08 00:00:00
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journal_title:Swiss medical weekly
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更新日期:2010-09-01 00:00:00
abstract:PURPOSE:To study the association between maternal smoking during pregnancy and low birth weight (LBW), small-for-gestational-age birth weight (SGA) and preterm birth, and to quantify the population-attributable fractions for these outcomes in Switzerland. METHODS:Data were gathered for all births in the Canton of Vaud...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2005/35/smw-11122
更新日期:2005-09-03 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2012.13673
更新日期:2012-09-20 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2004/33/smw-10599
更新日期:2004-08-21 00:00:00
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pub_type: 杂志文章
doi:10.4414/smw.2018.14597
更新日期:2018-03-14 00:00:00
abstract:QUESTION UNDER STUDY:What are the trends in avoidable cancer mortality in Switzerland and neighbouring countries? METHODS:Mortality data and population estimates 1996-2010 were obtained from the Swiss Federal Statistical Office for Switzerland and the World Health Organization Mortality Database (http://www.who.int/he...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2015.14184
更新日期:2015-10-02 00:00:00
abstract:QUESTIONS UNDER STUDY/PRINCIPLES:We describe the proportion of severely depressed outpatients reaching complete remission at the different stages of a drug treatment algorithm. We compare several treatment options for SSRI (selective serotonin reuptake inhibitor) non-responders and test the feasibility of the algorithm...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2006/05/smw-11267
更新日期:2006-02-04 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:2004/11/smw-10521
更新日期:2004-03-20 00:00:00
abstract:PRINCIPLES:A decrease in plasma lipids occurs during severe sepsis and has prognostic implications in critical illness. Whether lipids have prognostic implications or could help to differentiate community-acquired pneumonia from other lower respiratory tract infections remains unknown. METHODS:We analysed data from pa...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12494
更新日期:2009-03-21 00:00:00
abstract::According to World Health Organisation estimates 1.1 billion people were overweight or obese worldwide in the year 2000 with the prevalence rapidly increasing. Compelling evidence suggests that excess body weight is a risk factor for several cancer types including cancer of the colon, breast, endometrium, kidney, oeso...
journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2007/03/smw-11435
更新日期:2007-01-27 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:smw-12581
更新日期:2009-10-17 00:00:00
abstract:BACKGROUND:High quality chest compression is one of the key factors in successful resuscitation. A high standard of training is therefore decisive. We aimed to investigate the strengths and weaknesses of teaching chest compression in a study designed to highlight where targeted improvements in the quality of our chest ...
journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2011.13221
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abstract::Cartilage hair hypoplasia (CHH) is a rare autosomal recessive ribosomopathy characterised by skeletal and integumentary system manifestations. It may also present with varied forms and intensities of haematopoietic and/or immune disorders. We report a 27-year-old female who presented a picture of combined immunodefici...
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pub_type: 杂志文章,评审
doi:smw-12377
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2017.14425
更新日期:2017-04-18 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章
doi:10.4414/smw.2013.13871
更新日期:2013-10-25 00:00:00
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更新日期:2021-01-20 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:2003/29/smw-09986
更新日期:2003-07-26 00:00:00
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pub_type: 杂志文章
doi:10.4414/smw.2018.14636
更新日期:2018-07-09 00:00:00
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
doi:10.4414/smw.2015.14186
更新日期:2015-10-29 00:00:00