Abstract:
BACKGROUND:Adverse reactions to nonsteroidal antiinflammatory drugs (NSAIDs) are frequently reported, particularly among asthmatic patients. To date, there is no causal treatment available apart from tolerance induction. Therefore, the search for safe alternative drugs is of pivotal importance in clinical practice. OBJECTIVE:The aim of our prospective study was to investigate the tolerance to celecoxib, a selective cyclooxygenase-2 inhibitor, in a large group of patients with positive case history of NSAID intolerance in comparison to paracetamol and nimesulide. METHODS:106 NSAID-sensitive patients, 46 (43.4%) of whom had experienced reactions only to one NSAID (single hypersensitivity), 60 (56.6%) to several NSAIDs (multiple hypersensitivity), were included in a single-blinded drug challenge protocol with cumulative doses of 175 mg of celecoxib, 875 mg of paracetamol and 175 mg of nimesulide. Objective and subjective symptoms during challenge were documented. RESULTS:Of 261 challenges in 106 patients, 31 challenges were positive: 5 of 106 (4.7%) for celecoxib, 10 of 64 (15.6%) for paracetamol and 16 of 91 for nimesulide (17.6%). Adverse reactions to celecoxib were mainly mild in character: three patients reported subjective symptoms including generalised pruritus and thoracic oppression, whereas two patients reacted with angio-oedema. CONCLUSIONS:Our results demonstrate that celecoxib is well tolerated by the majority of patients with NSAID intolerance. However, since adverse reactions to celecoxib cannot be ruled out completely, a controlled oral challenge test is still mandatory for proper management of patients with NSAID intolerance.
journal_name
Swiss Med Wklyjournal_title
Swiss medical weeklyauthors
Roll A,Wüthrich B,Schmid-Grendelmeier P,Hofbauer G,Ballmer-Weber BKdoi
2006/43/smw-11358subject
Has Abstractpub_date
2006-10-28 00:00:00pages
684-90issue
43-44eissn
1424-7860issn
1424-3997pii
smw-11358journal_volume
136pub_type
临床试验,杂志文章abstract:BACKGROUND:Epidemiological studies focusing on first-ever seizures have been carried out mainly on community based populations. However, since hospital populations may display varying clinical features, we prospectively analysed patients with first-ever seizure in a hospital based community to evaluate prognosis and th...
journal_title:Swiss medical weekly
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abstract:PRINCIPLES:Small dense LDLs have been found to be associated with type 2 diabetes (T2DM). This association has been observed in the context of decreased HDL cholesterol and increased triglycerides. METHODS:In the present study the relationship between LDL particle size and insulin sensitivity was assessed in 46 patien...
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journal_title:Swiss medical weekly
pub_type: 杂志文章
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journal_title:Swiss medical weekly
pub_type: 杂志文章,评审
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journal_title:Swiss medical weekly
pub_type: 杂志文章
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journal_title:Swiss medical weekly
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pub_type: 杂志文章
doi:smw-12636
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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journal_title:Swiss medical weekly
pub_type: 杂志文章,多中心研究
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journal_title:Swiss medical weekly
pub_type: 杂志文章
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journal_title:Swiss medical weekly
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pub_type: 杂志文章,随机对照试验
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journal_title:Swiss medical weekly
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