Making sense of sentences in schizophrenia: electrophysiological evidence for abnormal interactions between semantic and syntactic processing.

Abstract:

:Event-related potentials to critical verbs were measured as patients with schizophrenia and healthy controls read sentences word by word. Relative to their preceding context, critical verbs were (a) congruous, (b) incongruous and semantically unrelated to individual preceding words (pragmatic-semantic violations), (c) incongruous but semantically related to individual preceding words (animacy-semantic violations), or (d) syntactically anomalous. The N400 was modulated normally in patients, suggesting that semantic integration between individual words within sentences was normal in schizophrenia. The amplitude of the P600 to both syntactic and animacy-semantic violations was reduced in patients relative to controls. The authors suggest that, in schizophrenia, an abnormality in combining semantic and syntactic information online to build up propositional meaning leaves sentence processing to be primarily driven by semantic relationships between individual words.

journal_name

J Abnorm Psychol

authors

Kuperberg GR,Sitnikova T,Goff D,Holcomb PJ

doi

10.1037/0021-843X.115.2.251

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

251-65

issue

2

eissn

0021-843X

issn

1939-1846

pii

2006-06737-012

journal_volume

115

pub_type

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