Abstract：
BACKGROUND:The adrenal gland may give rise to pheochromocytomas, which are catecholamine-producing tumors originating from the adrenal medulla, or to adrenocortical tumors, which derive from the adrenocortical cortex and may be secreting or not. The genetic mechanisms underlying the formation of these tumors include somatic mutations in susceptibility genes, especially in the familial forms, and allelic loss, especially in chromosome 1. AIM:The aim of this study was to investigate a third genetic mechanism by evaluating microsatellite instability using the reference markers (Bat25, Bat26, D2S123, D5S346, D17S250) validated by the National Cancer Institute. Microsatellite loci were analyzed in 32 benign tumors, including 11 pheochromocytomas and 21 adrenocortical tumors, in patients with and without familial syndrome. RESULTS:The different alleles of microsatellite loci were reliably detected by DNA fragments analysis, whereas data obtained after melting-point analysis on the Lightcycler were inconsistent. No microsatellite instability was detected in any tumor. One patient with a unilateral pheochromocytoma showed a loss of heterozygosity for D17S250. A second patient with a MEN-2A syndrome and a two-sided pheochromocytoma exhibited a loss of heterozygosity for D2S123 in the right tumor only and a retention of heterozygosity for all markers in the left tumor. CONCLUSIONS:These results suggest that microsatellite instability, evaluated by the five reference markers of the National Cancer Institute, is not a feature of benign adrenal tumors.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Namour F,Ayav A,Lu X,Klein M,Muresan M,Bresler L,Tramoy D,Guéant JL,Brunaud Ldoi
10.1007/s00268-005-0471-5subject
Has Abstractpub_date
2006-07-01 00:00:00pages
1240-6issue
7eissn
0364-2313issn
1432-2323journal_volume
30pub_type
杂志文章abstract：BACKGROUND:Because the feasibility and safety of laparoscopic approaches for the treatment of perforated peptic ulcer (PPU) have been fully recognized, laparoscopic repair of PPU (LPPU) has become a widely accepted procedure. Following closure of a PPU, the rationale to add an omental patch is based on the assumptions ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2503-5
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Laparoscopic rectal resection (LRR) for cancer is a challenging procedure, with conversion to open surgery being reported in up to 30% of cases. Since only a few studies with short follow-up have compared converted LRR and open RR (ORR), it is unclear if conversion to open surgery should be prevented by pref...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4614-x
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:The commonest surgical treatment used for peptic ulcer perforation is omental patching. If, however, the perforation leaks, it rarely heals by itself due to persistence of duodenal fistula (DF). We present our experience with a T-tube placed into the DF for better outcome of the patients. METHODS:All patien...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2196-1
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:The long-term course after peptic ulcer perforation is unclear, but because the ulcer population is generally older and has concomitant disease, the long-term prognosis may be expected to be poor. METHODS:In a study based on prospective data collection, all patients with peptic ulcer perforation treated at ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9370-2
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Postoperative ascites (POA) is a common complication after liver resection (LR). The aim of the present study was to identify the risk factors for developing POA and to evaluate its clinical significance in the prognosis of patients with hepatocellular carcinoma (HCC). METHODS:We performed a retrospective a...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1367-1
更新日期：2012-02-01 00:00:00
abstract：:Since the pathogenesis of endocrine ophthalmopathy is unclear, there has been little agreement on the treatment of the disease. The influence of thyroid surgery on endocrine ophthalmopathy is controversial. To evaluate the effect of thyroid surgery on the course of the disease, we developed a special ophthalmopathy in...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658552
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND:Closure of loop ileostomy can be safely performed using sutures or staplers. The aim of the present study was to compare the cost effectiveness of three different techniques. METHODS:A total of 128 consecutive patients who underwent closure of loop ileostomy between January 2002 and December 2008 were analy...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0787-7
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:We describe a new technique of segment-based liver resection by inserting a 6 French balloon catheter into the portal vein via a branch of the superior mesenteric vein. MATERIALS AND METHODS:The catheter was guided into the relevant portal branch supplying the liver segment that contained the tumor. Injecti...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9043-1
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:Intraoperative cerebral oxygen desaturation was reported to be associated with postoperative cognitive dysfunction in elderly patients. The effect of the anesthesia method on regional cerebral oxygen saturation (rSO(2)) is still a question under debate. The purpose of this study was to compare the effects of...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-012-1676-z
更新日期：2012-10-01 00:00:00
abstract：:We retrospectively reviewed postoperative complications in 105 patients with hilar cholangiocarcinoma who underwent hepatectomy at Nagoya University Hospital from January 1990 through March 1999. Of the 105 subjects, 97 (92.4%) underwent resection of two or more Healey's segments of the liver. Combined portal vein res...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-001-0110-8
更新日期：2001-10-01 00:00:00
abstract：OBJECTIVE:Radical lymph node dissection (LND) along the bilateral recurrent laryngeal nerve (RLN) is a surgically challenging procedure with a high rate of morbidity. Here, we assessed in a retrospective manner the adequacy of LND along the RLN performed with robot-assisted thoracoscopic esophagectomy (RATE) versus vid...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4179-0
更新日期：2018-02-01 00:00:00
abstract：:The effects of splenectomy in 41 patients managed from 1982 to 1995 at Sher-i-Kashmir Institute of Medical Sciences, Srinagar (Jammu and Kashmir), India, were studied. Immune thrombocytopenic purpura (ITP) was the main indication for therapeutic splenectomy among all the hematologic disorders. The mean age was 30 year...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689910017
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Neoadjuvant chemotherapy (NC) is standard therapy for patients with locally advanced breast cancer and is increasingly used for early-stage operable disease. Clinical and pathological responses are important prognostic parameters for NC, which aims to achieve a pathological complete response or tumor reducti...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9800-9
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Billions of people worldwide lack access to safe affordable surgery. Surgical missions and non-governmental organisations (NGO) are vital in meeting this need, but long-term outcomes are rarely reported. Mercy Ships is a surgical NGO, and we aimed to measure disability-free survival, impact and patient satis...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3745-1
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Neuroendocrine neoplasia (NEN) with unknown primary site (NEN-CUP tumors) may have a poor prognosis. We evaluated the clinical presentation, therapy, outcome, and risk factors for adverse outcomes in patients who had these tumors. METHODS:In 243 patients who had NEN, a retrospective review was performed in ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-2963-2
更新日期：2015-06-01 00:00:00
abstract：:Breast cancer is a common disease, and the surgical management is continually evolving. The objective of this study was to describe the current breast cancer practice patterns among Canadian surgeons. All active General Surgeons (n=1172), as accredited by the Royal College of Physicians and Surgeons of Canada, were se...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-7040-6
更新日期：2004-01-01 00:00:00
abstract：:There have been a growing number of landmark randomized controlled trials published in the orthopedic literature over the past decade. These large-scale trials have had a substantial impact on informing clinical orthopedic practice globally. This review highlights a selected sample of such pivotal trials, across the s...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-019-04955-7
更新日期：2020-04-01 00:00:00
abstract：:During the past four decades, especially in recent years, various active adjuvant therapies combined with surgery have improved the outcome in cases of cancer of the esophagus. However, no optimum adjuvant therapy has been determined. From 1981 to 1992, 341 patients with regional and distant node metastasis who underw...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF00316819
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:The skin is closed in open appendectomy traditionally with few interrupted nonabsorbable sutures. The use of this old method is based on a suggestion that this technique decreases wound infections. In pediatric surgery, skin closure with running intradermal absorbable sutures has been found to be as safe as ...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-012-1664-3
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Only few studies have compared laparoscopic total mesorectal excision (LTME) and open total mesorectal excision (OTME) for rectal cancer with follow-up longer than 5 years. The aim of this study was to compare 10-year oncologic outcomes after LTME and OTME for nonmetastatic rectal cancer. METHODS:We conduct...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3631-x
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:There are few established metrics to define surgical capacity in resource-limited settings. Previous work hypothesizes that the relative frequency of cesarean sections (CS) at a hospital, expressed as a proportion of total operative procedures (%CS), may serve as a proxy measure of surgical capacity. We atte...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1629-6
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Alternative methods to overcome limitations of electromyogram (EMG) tube applied for intraoperative neuromonitoring (IONM) of recurrent laryngeal nerve (RLN) during thyroidectomy have been introduced. In this study, we evaluated the feasibility of adhesive skin electrodes for IONM of RLN in patients who unde...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05208-3
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:There is a paucity of data on the presentation and surgical management of pheochromocytoma in developing nations, particularly in Africa. METHODS:This study was a retrospective review, which included all patients managed by the Groote Schuur Hospital/University of Cape Town Endocrine Surgery unit for pheoch...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05420-6
更新日期：2020-06-01 00:00:00
abstract：:Those benign breast disorders that are amenable to improvement by aesthetic surgery are discussed from the points of view of indications, techniques, and results. ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01658430
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the therapeutic efficacy of two surgical procedures used to treat middle thoracic esophageal squamous cell carcinoma and compare the results. METHODS:A total of 167 patients with middle thoracic esophageal squamous cell carcinoma were included in the study, including 10...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0341-7
更新日期：2010-02-01 00:00:00
abstract：:Nuss described a minimally invasive technique for correcting pectus excavatum in children. A curved stainless-steel bar is inserted behind the sternum through the chest cavity with the convex surface face down, then rotated 180 degrees to elevate the sternum and correct the deformity. The procedure gained wide accepta...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6519-x
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:The histone deacetylase (HDAC) inhibitors have emerged as the useful reagents that epigenetically modulate the expression of various genes. In the present study, the effects of HDAC inhibitors on the expression of inflammation-related genes and lung injury during sepsis were investigated. METHODS:Mice were ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0493-5
更新日期：2010-07-01 00:00:00
abstract：:A minority of patients with papillary thyroid carcinoma (PTC) is at high-risk of developing recurrent disease and death. Risk group stratification as defined by age, metastases to distant site, extrathyroidal invasion, and tumor size (AMES) criteria is frequently employed to identify high-risk patients for aggressive ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7420-6
更新日期：2004-11-01 00:00:00
abstract：:A variety of techniques have been used for surgical treatment of hepatic hydatid cysts. The objective of this study is to describe the technique of diaphragm myoplasty, and to present our experience in the treatment of selected patients with hydatid disease of the liver by means of this alternative surgical technique....
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6558-3
更新日期：2003-02-01 00:00:00
abstract：: ...
journal_title：World journal of surgery
pub_type： 评论,信件
doi：10.1007/s00268-019-04919-x
更新日期：2019-04-01 00:00:00
