Abstract:
BACKGROUND:The histone deacetylase (HDAC) inhibitors have emerged as the useful reagents that epigenetically modulate the expression of various genes. In the present study, the effects of HDAC inhibitors on the expression of inflammation-related genes and lung injury during sepsis were investigated. METHODS:Mice were pretreated with two structurally unrelated HDAC inhibitors, Trichostatin A (TSA) and sodium butyrate (SB). Thirty minutes later, mice underwent cecal ligation and puncture (CLP)-induced sepsis. Lung injury and the expression of inflammation-related molecules were determined. In addition, survival was assessed post-CLP. RESULTS:Our results indicated that administration of TSA or SB alleviated sepsis-induced lung injury. This was accompanied by reduced neutrophil infiltration, decreased intercellular adhesion molecule-1 (ICAM-1) and E-selectin expression in lung tissue, and lower interleukin-6 (IL-6) level in plasma. In addition, treatment with HDAC inhibitors significantly prolonged the survival time of CLP mice. CONCLUSIONS:These data indicated that the HDAC inhibitors, based on modulating the key enzymes linked to acetylation modification, effectively attenuate intrapulmonary inflammatory response, thus significantly alleviating lung injury during sepsis.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Zhang L,Jin S,Wang C,Jiang R,Wan Jdoi
10.1007/s00268-010-0493-5subject
Has Abstractpub_date
2010-07-01 00:00:00pages
1676-83issue
7eissn
0364-2313issn
1432-2323journal_volume
34pub_type
杂志文章abstract:BACKGROUND AND AIM:Previous studies have shown that microscopic vessel invasion (MVI) occurs in hepatocellular carcinoma (HCC) with a treatment history due to its poorer malignant behavior in comparison with primary HCC. The aim of the present study was to determine the predictors of MVI and overall survival in HCC pat...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4658-y
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Pilonidal sinus is a common chronic disease affecting young adults. Many surgical procedures have been developed for its treatment, but an optimal one has still not been achieved. This study presents a modification to the Karydakis operation. METHODS:A total of 265 patients with chronic pilonidal sinus betw...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4406-8
更新日期:2018-06-01 00:00:00
abstract::Numerous clinicopathologic factors have been reported to have prognostic significance for gastrointestinal cancer. Many problems, however, confront the surgeon assessing the extent of disease and the clinical and molecular pathologist distinguishing differences in tumor differentiation, behavior, and defining importan...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF00308623
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Patients with hepatocellular carcinoma (HCC) who underwent hepatectomy often developed an intrahepatic recurrence, even though it was a curative one. The relationship between surgery-induced liver damage and the recurrence of HCC has not been described. This study evaluated whether posthepatectomy liver fail...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2247-7
更新日期:2014-01-01 00:00:00
abstract::We sought to determine whether early eschar excision en masse (EEE) at one operation would be effective in the prevention and treatment of postburn organ dysfunction (OD) and multiple organ dysfunction syndrome (MODS). A total of 60 patients, with total body surface burned area over 35% and a third degree burn area ov...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900661
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Esophagectomy remains the standard treatment for resectable esophageal cancer, but the cure rate is low. Neoadjuvant therapy has been tried in attempts to prolong survival and reduce tumor recurrence. The aim of this study was to assess the surgical outcomes with and without neoadjuvant treatment for resecta...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-006-0016-6
更新日期:2006-12-01 00:00:00
abstract::Fifty patients reoperated for failed Nissen fundoplication are presented; 29 patients (group 2) were operated between 1983 and 1988 while 21 patients (group 1) were operated before 1983. In group 1, the "slipped Nissen" had been the most frequent cause of reoperation (48%). In group 2, the most frequent causes for the...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01658439
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Mutations in BRCA1 and BRCA2 confer an increased risk to breast and other cancers, but to date there have only been limited numbers of studies of BRCA1- and BRCA2-associated cancers among Asians. Malaysia is a multiracial country with three main races: Malays, Chinese, Indians. We determined whether tumor pa...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0146-8
更新日期:2009-10-01 00:00:00
abstract:PURPOSE:The aim of the study was to evaluate risk factors for small bowel obstruction (SBO) in early postoperative period after anterior resection for rectal cancer. METHODS:Patients who underwent anterior resection (AR) [high AR (HAR) or low AR (LAR)] for rectal cancer between January 2009 and April 2016 were enrolle...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4152-y
更新日期:2018-01-01 00:00:00
abstract::Clinical parameters alone have repeatedly been proven unreliable in assessing cardiopulmonary status, especially in hemodynamically unstable patients. To learn if we had a diagnostic problem in our hospital, we compared physician assessment of cardiac index (CI) and thoracic fluid content (TFC) to values obtained usin...
journal_title:World journal of surgery
pub_type: 临床试验,杂志文章
doi:10.1007/s00268-004-2073-z
更新日期:2005-01-01 00:00:00
abstract::Thyrotoxicosis is the clinical syndrome that results when tissues are exposed to high levels of circulating thyroid hormones. In most instances thyrotoxicosis is due to hyperthyroidism, a term reserved for disorders characterized by overproduction of thyroid hormones by the thyroid gland. Nevertheless, thyrotoxicosis ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s002680010228
更新日期:2000-11-01 00:00:00
abstract::Genital manifestations of lymphatic filariasis (genital LF) are a significant cause of disfigurement and disability in the developing world. Surgery is the standard treatment; however, definitive publications are lacking and best practice remains unclear. An exhaustive search strategy using keyword and subject heading...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-015-3220-4
更新日期:2015-12-01 00:00:00
abstract::Endoscopic ultrasonography (EUS) and computed tomography (CT) should be used as complementary methods for TNM staging of esophageal cancer. EUS is the most accurate modality for staging primary tumor and mediastinal lymph node metastases. CT should be used to detect infiltration of other mediastinal organs and distant...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF00316809
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Little is known of the oncological outcomes after adjuvant FOLFOX chemotherapy in patients with stage III colon cancer showing microsatellite instability high (MSI-H). In the present study we investigated the prognostic impact of MSI-H in patients with stage III colon cancer receiving FOLFOX chemotherapy. M...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2120-8
更新日期:2013-10-01 00:00:00
abstract::A mathematic model is created to determine the economic cost per year of anticipated prolongation of life that would result from a program of abdominal ultrasonographic (US) screening for abdominal aortic aneurysm. The protocol involves US screening at age 60, 67, and 74 years with additional annual follow-up US and e...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01659032
更新日期:1989-05-01 00:00:00
abstract::During the past four decades, especially in recent years, various active adjuvant therapies combined with surgery have improved the outcome in cases of cancer of the esophagus. However, no optimum adjuvant therapy has been determined. From 1981 to 1992, 341 patients with regional and distant node metastasis who underw...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF00316819
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The extrahepatic surgical technique in liver resection can be divided into glissonean pedicle transection and glissonean separated transection approaches. In this study, we compared remnant liver function and liver regeneration involving the Spiegel lobe between these two approaches regarding Spiegel lobe-pr...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05548-5
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:This study was intended to compare the prognostic power of the number of positive lymph nodes with that of the lymph node ratio in patients with ampullary carcinoma. METHODS:A retrospective analysis was conducted of the medical records of 71 consecutive patients with ampullary carcinoma who underwent pancre...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1175-7
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:The specific definition of central hepatectomy (CH) (i.e., resection of segments 4-5-8 ± 1) is not uniformly used, resulting in conflicting comparisons with the more commonly performed extended hepatectomy (EH). The study aimed to compare, using propensity score matching (PSM) analysis, the incidence of post...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-016-3584-0
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Uncomplicated acute appendicitis has been managed traditionally by early appendicectomy. However, recently, there has been increasing interest in the potential for primary treatment with antibiotics, with studies finding this to be associated with fewer complications than appendicectomy. The aim of this stud...
journal_title:World journal of surgery
pub_type: 杂志文章,meta分析
doi:10.1007/s00268-016-3561-7
更新日期:2016-10-01 00:00:00
abstract::Radiation therapy has been widely used for palliative management of inoperable metastatic malignant melanoma. For patients with nodal disease, response rates of approximately 70% have been reported. There are limited data concerning the role of adjuvant irradiation following therapeutic lymph node dissection. In this ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00299160
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:We sought to identify affordable and sustainable methods to strengthen trauma care capabilities globally, especially in developing countries, using the Guidelines for Essential Trauma Care. These guidelines were created by the World Health Organization (WHO) and the International Society of Surgery and provi...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-0768-4
更新日期:2006-06-01 00:00:00
abstract::Persistent pain after hernia repair is common, although it is usually mild. In 3% of patients it is severe, however, and has significant effects on work and social activities. The purpose of this review was to examine factors that affect pain after hernia repair. Although the type of anaesthetic used, local or general...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-005-7903-0
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Classification of the open abdomen (OA) status is essential for clinical studies on the subject and may help to improve OA therapy. This is a validity and reliability analysis of the OA classification proposed by the World Society of the Abdominal Compartment Syndrome in 2013. METHODS:Prospective data on 11...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2716-7
更新日期:2014-12-01 00:00:00
abstract::A minority of patients with papillary thyroid carcinoma (PTC) is at high-risk of developing recurrent disease and death. Risk group stratification as defined by age, metastases to distant site, extrathyroidal invasion, and tumor size (AMES) criteria is frequently employed to identify high-risk patients for aggressive ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-004-7420-6
更新日期:2004-11-01 00:00:00
abstract::The value of surgical resection for patients with chronic pancreatitis has been debated on account of persistent symptoms and the morbidity of the operative procedure, both immediate and delayed. This paper explores the consequence of pancreatoduodenectomy in 175 patients with chronic pancreatitis who were operated on...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-003-7239-6
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:Advanced Trauma Life Support (ATLS®) is one of the world's best-known training programs for medical providers. Revisions of the ATLS manual have been evidence based for a number of years. In 2011, a level 3 (S3) evidence- and consensus-based guideline on the treatment of patients with severe and multiple injuri...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-015-3063-z
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Frequent use of computed tomography (CT) in trauma patients results in frequent detection of non-trauma-related incidental findings (IFs). Inpatient documentation and disclosure at discharge are infrequent, even when they are potentially serious. We aimed to not only identify the incidence of IFs but also to...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2092-8
更新日期:2013-09-01 00:00:00
abstract::The role of nitric oxide in mediating smooth muscle relaxation is well established. Less is known about the downstream signaling events inside the smooth muscle cell that produce relaxation of the contractile machinery. One possible effector molecule is the small heat shock protein HSP20. Increased phosphorylation of ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-002-4052-6
更新日期:2002-07-01 00:00:00
abstract::The aim of this study was to determine if fat absorption is better after pylorus-preserving pancreatoduodenectomy (PPPD) or duodenum-preserving pancreatic head resection (DPPHR) compared with that following pancreatoduodenectomy with gastrectomy (SPD), provided the patients have similar pancreatic exocrine function. F...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900156
更新日期:1996-10-01 00:00:00