Duration of survival after peptic ulcer perforation.

Abstract:

BACKGROUND:The long-term course after peptic ulcer perforation is unclear, but because the ulcer population is generally older and has concomitant disease, the long-term prognosis may be expected to be poor. METHODS:In a study based on prospective data collection, all patients with peptic ulcer perforation treated at the Department of Surgery at the Heinrich-Heine-University in Dusseldorf, Germany, were documented between 1986 and 1995. In a follow-up study, the following parameters were investigated and survival rates were estimated: hospital mortality, 1-month mortality, 1-year mortality, and 5-year mortality. Significant prognostic parameters for death were worked out in univariate and multivariate analysis. RESULTS:Ninety-nine out of 108 patients with peptic ulcer perforation could be followed-up. One-month mortality was similar to hospital mortality, at 9.1%; 1-year mortality was about 20.2%; and 5-year mortality was 32.3%. Statistically significant prognostic factors for death in univariate analysis were age beyond 70 years, concomitant diseases, risk-related drugs, postinterventional complications and admission status. In multivariate analysis concomitant diseases, postoperative complications, and advanced age were significant parameters for death. CONCLUSIONS:Long-term prognosis of peptic ulcer perforation is poor. Risk factors for late mortality after peptic ulcer perforation are age, severe concomitant diseases, and postinterventional complications.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Imhof M,Epstein S,Ohmann C,Röher HD

doi

10.1007/s00268-007-9370-2

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

408-12

issue

3

eissn

0364-2313

issn

1432-2323

journal_volume

32

pub_type

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