Abstract:
BACKGROUND AND AIMS:Dietary folate is believed to protect against colorectal cancer (CRC). However, few studies have addressed the role of circulating levels of folate. The aim of this study was to relate prediagnostic plasma folate and homocysteine concentrations and the methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms to the risk of developing CRC. SUBJECTS:Subjects were 226 cases and 437 matched referents from the population based Northern Sweden Health and Disease Cohort. RESULTS:We observed a bell-shaped association between plasma folate concentrations and CRC risk; multivariate odds ratio for middle versus lowest quintile 2.00 (95% confidence interval (CI) 1.13-3.56). In subjects with follow up times greater than the median of 4.2 years however, plasma folate concentrations were strongly positively related to CRC risk; multivariate odds ratio for highest versus lowest quintile 3.87 (95% CI 1.52-9.87; p trend = 0.007). Homocysteine was not associated with CRC risk. Multivariate odds ratios for the MTHFR polymorphisms were, for 677 TT versus CC, 0.41 (95% CI 0.19-0.85; p trend = 0.062), and for 1298 CC versus AA, 1.62 (95% CI 0.94-2.81; p trend = 0.028). Interaction analysis suggested that the result for 1298A>C may have been largely due to linkage disequilibrium with 677C>T. The reduced CRC risk in 677 TT homozygotes was independent of plasma folate status. CONCLUSIONS:Our findings suggest a decreased CRC risk in subjects with low folate status. This possibility of a detrimental component to the role of folate in carcinogenesis could have implications in the ongoing debate in Europe concerning mandatory folate fortification of foods.
journal_name
Gutjournal_title
Gutauthors
Van Guelpen B,Hultdin J,Johansson I,Hallmans G,Stenling R,Riboli E,Winkvist A,Palmqvist Rdoi
10.1136/gut.2005.085480subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1461-6issue
10eissn
0017-5749issn
1468-3288pii
gut.2005.085480journal_volume
55pub_type
杂志文章,多中心研究相关文献
GUT文献大全abstract::To assess the value of pneumatic dilatation of the cardia, 63 patients with achalasia have undergone a total of 107 Rider-Moeller dilatations over the last six years. There was a marked improvement in swallowing immediately after dilatation in all but two patients, there were no deaths attributable to the procedure an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.11.1020
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. OBJECTIVE:To explore miRNAs that are regulated with the progression of liver fibrosis caused by chronic liver disease. DESIGN:The regulated miRNAs in human livers infected with hepatitis C virus were identified...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300717
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Pancreatic cancer is among the most dismal of human malignancies. Current therapeutic strategies are virtually ineffective in controlling advanced, metastatic disease. Recent evidence suggests that the Hedgehog signalling pathway is aberrantly reactivated in the majority of pancreatic cancers, and t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.148189
更新日期:2008-10-01 00:00:00
abstract::One-hundred-and-one normal neonates were examined manometrically in the first day of life to assess anorectal function. In order to overcome some of the difficulties in subjective interpretation of results, the stimuli used and the response pattern seen in the anal canal were measured. In the unstimulated state, all s...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.12.1036
更新日期:1977-12-01 00:00:00
abstract::To determine the significance of the endoscopic classification of gastritis proposed by a working party at the World Congress of Gastroenterology in Sydney 1990, 167 patients undergoing upper alimentary endoscopy were prospectively assessed by comprehensive endoscopic and histological methods. Ninety eight patients ha...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.9.1172
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Early events in the progression of 90% of sporadic colorectal cancers depend on constitutive activation of Wnt signalling. Recent data also indicate a close association between the Hedgehog (Hh) and Wnt pathways in colonic epithelial cell differentiation. AIMS:To investigate whether expression of Gli1, a tr...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.080333
更新日期:2006-07-01 00:00:00
abstract::To assist in the prediction of variceal bleeding we examined 12 clinical, endoscopic and haemodynamic variables in 126 patients with portal hypertension (72 bleeders and 54 non-bleeders). Multiple regression and discriminant analysis were utilised for 101 patients. Stepwise regression among the 12 variables explained ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.12.1757
更新日期:1989-12-01 00:00:00
abstract::To determine the optimum bile acid regimen for rapid gall stone dissolution, 48 gall stone patients were divided into four groups of 12 according to stone diameter and were randomly allocated to receive one of four treatment regimens: bedtime or mealtime chenodeoxycholic acid (CDCA, 12 mg/kg/day) and bedtime or mealti...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.33.3.381
更新日期:1992-03-01 00:00:00
abstract::Thirty two patients with active Crohn's disease were included in a controlled randomised trial to determine the efficacy and safety of polymeric enteral nutrition compared with steroids, to achieve and maintain clinical remission. The polymeric diet was administered through a fine bore nasogastric tube by continuous, ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.6.778
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:The prognosis of patients with hepatocellular carcinoma (HCC) remains poor, and new alternative treatments are needed. AIMS:To comparatively test the angiostatic and antitumour effects of adenoviral gene transfer of angiostatin (PlgK1-4, amino acids 1-440) and full kringles 1-5 (PlgK1-5, amino acids 1-546) ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.088583
更新日期:2007-02-01 00:00:00
abstract::The lectin, phytohaemagglutinin, present in beans survives passage through the gastrointestinal tract in a biologically and immunologically intact form. It is known that by binding to the brush border membranes of the small intestine phytohaemagglutinin induces its hyperplastic growth. However, its effect on the other...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.3.353
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND AND AIM:There are few data on the course of Helicobacter pylori infection in asymptomatic subjects. The aim of this study was to assess the effect of eradication therapy on the development of dyspeptic and gastro-oesophageal reflux disease in a cohort of asymptomatic individuals observed over a prolonged per...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.11.1543
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Intestinal metaplasia, whether in the cardia or the distal oesophagus, has been uniformly defined as specialised columnar epithelium, suggesting a relation with Barrett's oesophagus. It is, however, not clear whether the risk factors associated with intestinal metaplasia are identical at both sites. AIMS:To...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.1.17
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate the response of endocrine cells of the gastric oxyntic mucosa in hypergastrinaemic patients to either antrectomy or treatment with the somatostatin analogue octreotide. PATIENTS:(a) Two patients with enterochromaffin-like (ECL) cell carcinoid and chronic atrophic gastritis, treated with ant...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.38.5.668
更新日期:1996-05-01 00:00:00
abstract::The gastric secretory response to insulin changes in many patients between ;immediate' tests, within two weeks of vagotomy, and ;delayed' tests, done at least six months later. Patients who develop recurrent duodenal ulceration after vagotomy and pyloroplasty show highly significant increases in peak and rise in conce...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.4.303
更新日期:1971-04-01 00:00:00
abstract::Of 279 patients admitted to a specialist unit with acute pancreatitis, 210 were admitted directly and 69 were transferred for treatment of local or systemic complications. Outcome was assessed in terms of mortality and morbidity and in relation to aetiology, predicted severity of disease (modified Glasgow score), orga...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.1.121
更新日期:1995-07-01 00:00:00
abstract::A study of the function of the lower end of the oesophagus in the cat confirms that it behaves as a true physiological sphincter, even though histological evidence for such a structure is absent. Sphincteric action is a function of the circular muscle fibres in the lowest 2 cm. of the oesophagus. Reflex changes in ton...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2.3.252
更新日期:1961-09-01 00:00:00
abstract::The association between Cryptosporidium, chronic diarrhoea and a proximal small intestinal mucosal enteropathy was reviewed over a six and a half year period. One hundred and twenty three children with cryptosporidiosis and no clinical evidence of immune deficiency were identified. 50% of children excreting only Crypt...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.8.1057
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND AND AIMS:One of the key components of inflammation is changes in vascular structure and function. This suggests that the microcirculation may be a key target of Helicobacter pylori released factors. It has previously been shown in vivo that pooled H pylori extracts from duodenal ulcer/gastritis patients indu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.5.641
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:In this study, we identify the nature of the immunological response of human peripheral blood mononuclear cells (PBMC) and lamina propria gastric lymphocytes (LPL) to two Helicobacter pylori antigens, the neutrophil activating protein (NapA) and alkyl hydroperoxide reductase (AphC). These antigens were ident...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.025494
更新日期:2005-01-01 00:00:00
abstract::The quantification of gastric, pancreatic, biliary, and small bowel functions in man often requires the use of intestinal tubes. In this study, the presence of a transpyloric tube did not alter gastric emptying, acid secretion, or serum gastrin levels in response to an ordinary solid meal. ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.16.10.777
更新日期:1975-10-01 00:00:00
abstract::These consensus guidelines were jointly commissioned by the British Society of Gastroenterology (BSG), the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and Public Health England (PHE). They provide an evidence-based framework for the use of surveillance colonoscopy and non-colonoscopic colorecta...
journal_title:Gut
pub_type: 杂志文章,实务指引
doi:10.1136/gutjnl-2019-319858
更新日期:2020-02-01 00:00:00
abstract::A comparative analysis of pancreatic morphology and exocrine function was performed prospectively in 48 patients. All patients had transabdominal ultrasound, computed tomography, endoscopic retrograde pancreatography, and a secretin-caerulein test. Classification of ultrasound, computed tomography, and pancreatogram f...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.8.1132
更新日期:1994-08-01 00:00:00
abstract::Eight patients with traumatic transverse lesions of the spinal cord and eight healthy controls were examined with respect to the function of the anal sphincters. Continuous recordings of anal pressure and electromyograms from the striated sphincter muscles were obtained during gradual rectal distension by means of an ...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.16.8.638
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Zinc carnosine (ZnC) is a health food product claimed to possess health-promoting and gastrointestinal supportive activity. Scientific evidence underlying these claims is, however, limited. AIM:To examine the effect of ZnC on various models of gut injury and repair, and in a clinical trial. METHODS:In vitr...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gut.2006.099929
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Surgical management of extrahepatic cholestasis is frequently complicated by bacterial translocation and severe liver injury. The aim of this study was to clarify the involvement of Toll-like receptors (TLRs) in the pathogenesis of bacterial translocation and liver injury in obstructive cholestasis....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.065318
更新日期:2006-01-01 00:00:00
abstract::Small bowel enteropathies that are associated with an autoimmune process are often resistant to treatment. Two children with autoimmune enteropathy were treated with cyclosporin A for eight months. Both improved, as assessed by growth, small intestinal mucosal morphology, and carbohydrate absorption. Cyclosporin A is ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.11.1421
更新日期:1991-11-01 00:00:00
abstract::Jejunal biopsies from 15 Greenlandic and three Danish patients with adult type hypolactasia and nine Greenlandic and 15 Danish patients with normal lactase activity were analysed quantitatively for lactase protein by crossed immunoelectrophoresis. A constant correlation between the amount of lactase activity and immun...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.5.360
更新日期:1980-05-01 00:00:00
abstract::In order to establish whether alcohol in amounts in amounts customarily imbibed during social drinking causes gastro-oesophageal reflux, 12 healthy young individuals, without symptoms of gastro-oesophageal reflux, were studied twice. Each time, distal oesophageal pH was monitored continuously for three hours after a s...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.19.4.336
更新日期:1978-04-01 00:00:00
abstract::The influence of dehydrocholate on bromsulphtalein relative-storage capacity, bilary transport maximum (Tm), and fractional transfer rates between plasma, liver and bile have been studied in unanaesthetized dogs. In six dogs, storage capacity, Tm, and fractional transfer rates from plasma to liver, liver to bile, and ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.16.2.105
更新日期:1975-02-01 00:00:00