Chaotic motion of a weakly nonlinear, modulated oscillator.

abstract：:Uropathogenic Escherichia coli invade bladder epithelial cells (BECs) by direct entry into specialized cAMP regulated exocytic compartments. Remarkably, a significant number of these intracellular bacteria are subsequently expelled in a nonlytic and piecemeal fashion by infected BECs. Here, we report that expulsion of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song J,Bishop BL,Li G,Grady R,Stapleton A,Abraham SN

更新日期：2009-09-01 00:00:00

abstract：:We report on the expression of thymidine kinase (tk) activity in synchronized populations of mouse cells that have been transformed to the tk+ phenotype with purified DNA from various sources or with metaphase chromosomes from human cells. The viral (herpes) tk gene is constitutively expressed but, in all other cases ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlosser CA,Steglich C,deWet JR,Scheffler IE

更新日期：1981-02-01 00:00:00

abstract：:Dual inactivation of PTEN and INK4a/ARF tumor suppressor genes is a common feature observed in a broad spectrum of human cancer types. To validate functional collaboration between these genes in tumor suppression, we examined the biological consequences of Pten and/or Ink4a/Arf deficiency in cells and mice. Relative t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： You MJ,Castrillon DH,Bastian BC,O'Hagan RC,Bosenberg MW,Parsons R,Chin L,DePinho RA

更新日期：2002-02-05 00:00:00

abstract：:We have developed an approach for deriving and characterizing antigen-receptor (CD3/Ti) signal-transduction mutants. This strategy combines receptor-mediated growth inhibition and fluorescence-activated cell sorting with the Ca2+-indicator indo-1. Despite the expression of structurally normal CD3/Ti complexes, one suc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldsmith MA,Weiss A

更新日期：1987-10-01 00:00:00

abstract：:The convulsant agent methionine sulfoximine inhibits brain glutamine synthetase irreversibly and the inhibitor becomes bound to the active site of the enzyme as methionine sulfoximine phosphate. Only one of the four isomers of methionine sulfoximine, L-methionine-S-sulfoximine, inhibits glutamine synthetase. In the pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowe WB,Meister A

更新日期：1970-06-01 00:00:00

abstract：:When encountering unexpected event changes, memories of relevant past experiences must be updated to form new representations. Current models of memory updating propose that people must first generate memory-based predictions to detect and register that features of the environment have changed, then encode the new eve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stawarczyk D,Wahlheim CN,Etzel JA,Snyder AZ,Zacks JM

更新日期：2020-11-24 00:00:00

abstract：:Preference behaviors are often established during early life, but the underlying neural circuit mechanisms remain unknown. Adapting a unique nesting behavior assay, we confirmed a "critical period" for developing music preference in C57BL/6 mice. Early music exposure between postnatal days 15 and 24 reversed their inn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang EJ,Lin EW,Hensch TK

更新日期：2012-10-16 00:00:00

abstract：:RPE65 is a protein of unknown function expressed specifically by the retinal pigment epithelium. We examined all 14 exons of this gene in 147 unrelated patients with autosomal recessive retinitis pigmentosa (RP), in 15 patients with isolate RP, and in 45 patients with Leber congenital amaurosis (LCA). Sequence anomali...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morimura H,Fishman GA,Grover SA,Fulton AB,Berson EL,Dryja TP

更新日期：1998-03-17 00:00:00

abstract：:We propose that retroviruses exploit a cell-encoded pathway of intercellular vesicle traffic, exosome exchange, for both the biogenesis of retroviral particles and a low-efficiency but mechanistically important mode of infection. This Trojan exosome hypothesis reconciles current paradigms of retrovirus-directed transm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gould SJ,Booth AM,Hildreth JE

更新日期：2003-09-16 00:00:00

abstract：:To understand complex biological systems, such as the development of multicellular organisms, it is important to characterize the gene expression dynamics. However, there is currently no universal technique for targeted insertion of reporter genes and quantitative imaging in multicellular model systems. Recently, geno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ochiai H,Sakamoto N,Fujita K,Nishikawa M,Suzuki K,Matsuura S,Miyamoto T,Sakuma T,Shibata T,Yamamoto T

更新日期：2012-07-03 00:00:00

abstract：:Chromophore-assisted light inactivation is a promising technique to inactivate selected proteins with high spatial and temporal resolution in living cells, but its use has been limited because of the lack of a methodology to prevent nonspecific photodamage in the cell owing to reactive oxygen species generated by the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yogo T,Urano Y,Mizushima A,Sunahara H,Inoue T,Hirose K,Iino M,Kikuchi K,Nagano T

更新日期：2008-01-08 00:00:00

abstract：:We report a measurement of the transverse momentum correlation between two photons by detecting only one of them. Our method uses two identical sources in an arrangement in which the phenomenon of induced coherence without induced emission is observed. In this way, we produce an interference pattern in the superpositi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hochrainer A,Lahiri M,Lapkiewicz R,Lemos GB,Zeilinger A

更新日期：2017-02-14 00:00:00

abstract：:Mammalian homologues of Drosophila Trp form plasma membrane channels that mediate Ca(2+) influx in response to activation of phospholipase C and internal Ca(2+) store depletion. Previous studies showed that human Trp3 is activated by inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) and identified interacting d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Z,Tang J,Tikunova S,Johnson JD,Chen Z,Qin N,Dietrich A,Stefani E,Birnbaumer L,Zhu MX

更新日期：2001-03-13 00:00:00

abstract：:Animal epithelial tissue becomes reproducibly colonized by specific environmental bacteria. The bacteria (microbiota) perform critical functions for the host's tissue development, immune system development, and nutrition; yet the processes by which bacterial diversity in the environment is selected to assemble the cor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brooks JF 2nd,Gyllborg MC,Cronin DC,Quillin SJ,Mallama CA,Foxall R,Whistler C,Goodman AL,Mandel MJ

更新日期：2014-12-02 00:00:00

abstract：:Membranes were purified from rat muscle by a differential centrifugation method that avoids the use of salt extraction or incubations at elevated temperature. Three populations of membrane-limited vesicles were defined having average densities of 1.112 (fraction I), 1.141 (fraction II), and 1.158 (fraction III) g/ml i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barchi RL,Bonilla E,Wong M

更新日期：1977-01-01 00:00:00

abstract：:We report measurements of the geometrical structure and temporal evolution of metastable helical intermediates in the pathway for cholesterol crystallization in native and model biles. We find that the lecithin component in the bile can dramatically affect the kinetics along this pathway. We also present a theoretical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung DS,Benedek GB,Konikoff FM,Donovan JM

更新日期：1993-12-01 00:00:00

abstract：:ATP is copackaged and coreleased with adrenergic, serotonergic, and cholinergic neurotransmitters, suggesting a possible interaction between the signaling pathways for ATP and these coreleased neurotransmitters. Muscarinic m2 and m4, alpha 2-adrenergic, and D2-dopaminergic neurotransmitter receptors, which have in com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felder CC,Williams HL,Axelrod J

更新日期：1991-08-01 00:00:00

abstract：:The importance of Gly-93 and Gly-94 in transmembrane segment M1 of the Na+,K+-ATPase for interaction with Na+ and K+ was demonstrated by functional analysis of mutants Gly-93-Ala and Gly-94-Ala. In the crystal structures of the Ca2+-ATPase, the corresponding residues, Asp-59 and Leu-60, are located exactly where M1 be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Einholm AP,Toustrup-Jensen M,Andersen JP,Vilsen B

更新日期：2005-08-09 00:00:00

abstract：:Addition of acetylcholine to growing cultures of mouse neuroblastoma cells induced a 37-fold increase in the specific activity of acetylcholinesterase (EC 3.1.1.7). Morphological changes, consisting of neurite-extensions, were also observed during the logarithmic phase of growth of cells stimulated with acetylcholine....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harkins J,Arsenault M,Schlesinger K,Kates J

更新日期：1972-11-01 00:00:00

abstract：:A discrepancy is explored regarding the spin exchange integral estimated from magnetic field effects on recombination of the bacteriochlorophyll dimer cation (Bchl)(2)+ and the bacteriopheophytin anion Bph(-) and the measured electron transfer rate between Bph and electronically excited (Bchl)(2). In one explanation c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haberkorn R,Michel-Beyerle ME,Marcus RA

更新日期：1979-09-01 00:00:00

abstract：:An enduring question in correlated systems concerns whether superconductivity is favored at a quantum critical point (QCP) characterized by a divergent quasiparticle effective mass. Despite such a scenario being widely postulated in high T(c) cuprates and invoked to explain non-Fermi liquid transport signatures, exper...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sebastian SE,Harrison N,Altarawneh MM,Mielke CH,Liang R,Bonn DA,Hardy WN,Lonzarich GG

更新日期：2010-04-06 00:00:00

abstract：:Emotional signals are crucial for sharing important information, with conspecifics, for example, to warn humans of danger. Humans use a range of different cues to communicate to others how they feel, including facial, vocal, and gestural signals. We examined the recognition of nonverbal emotional vocalizations, such a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sauter DA,Eisner F,Ekman P,Scott SK

更新日期：2010-02-09 00:00:00

abstract：:Lipoxin B (LXB) was prepared by incubation of (15S)-15-hydroperoxy-5,8,11-cis-13-trans-icosatetraenoic acid (15-HPETE) with human leukocytes. Comparison with a number of trihydroxyicosatetraenes prepared by total synthesis showed that biologically derived LXB is (5S,14R,15S)-5,14,15-trihydroxy-6,10,12-trans-8-cis-icos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serhan CN,Hamberg M,Samuelsson B,Morris J,Wishka DG

更新日期：1986-04-01 00:00:00

abstract：:Asymmetric epoxidation of various styrenes using carbocyclic oxazolidinone-containing ketone 3 has been investigated. High enantioselectivity (89-93% enantiomeric excess) has been attained for this challenging class of alkenes. Mechanistic studies show that substituents on the ketone catalyst can have electronic influ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hickey M,Goeddel D,Crane Z,Shi Y

更新日期：2004-04-20 00:00:00

abstract：:Somatic cell hybrids have been prepared at high frequency between the rat muscle cell line L6 and human fetal muscle cells. The hybrid cells express several human gene products including an antigen, 12E7, controlled by the human X chromosome, Thy-1, and several human isoenzymes. In addition, one clone (37-11) expresse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quinn CA,Goodfellow PN,Povey S,Walsh FS

更新日期：1981-08-01 00:00:00

abstract：:Large quantities of mineral dust particles are frequently ejected into the atmosphere through the action of wind. The surface of dust particles acts as a sink for many gases, such as sulfur dioxide. It is well known that under most conditions, sulfur dioxide reacts on dust particle surfaces, leading to the production ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dupart Y,King SM,Nekat B,Nowak A,Wiedensohler A,Herrmann H,David G,Thomas B,Miffre A,Rairoux P,D'Anna B,George C

更新日期：2012-12-18 00:00:00

abstract：:Protein synthesis initiation in reticulocyte lysates is inhibited by heme deficiency, low levels of double-stranded RNA (dsRNA), oxidized glutathione (GSSG), or the purified kinase (HRI) that acts on the alpha polypeptide of eukaryotic initiation factor 2 (eIF-2alpha). The phosphoprotein profiles produced in lysates i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ernst V,Levin DH,London IM

更新日期：1979-05-01 00:00:00

abstract：:R. A. Fisher's 1930 "reproductive value" is defined as the contribution made by a population's initial age elements to its asymptotically dominating exponential growth mode. For the Leslie discrete-time model, it is the characteristic row vector of the Leslie matrix, and for the integral-equation model of Lotka the si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuelson PA

更新日期：1977-11-01 00:00:00

abstract：:Small proteins can fold remarkably rapidly, even in μs. What limits their rate of folding? The Engrailed homeodomain is a particularly well-characterized example, which folds ultrafast via an intermediate, I, of solved structure. It is a puzzle that the helix2-turn-helix3 motif of the 3-helix bundle forms in approxima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neuweiler H,Banachewicz W,Fersht AR

更新日期：2010-12-21 00:00:00

abstract：:In vitro and in vivo triplet state electron paramagnetic resonance (epr) spectra of bacteriochlorophylls (Bchls) show important differences in (a) electron spin polarization (esp), and (b) zero field splitting (ZFS) parameters. The unusual esp and ZFS properties of the observed in vivo triplet state are best interpret...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thurnauer MC,Katz JJ,Norris JR

更新日期：1975-09-01 00:00:00