Abstract:
:Regulated exocytosis is thought to occur either by "full fusion," where the secretory vesicle fuses with the plasma membrane (PM) via a fusion pore that then dilates until the secretory vesicle collapses into the PM; or by "kiss-and-run," where the fusion pore does not dilate and instead rapidly reseals such that the secretory vesicle is retrieved almost fully intact. Here, we describe growing evidence for a third form of exocytosis, dubbed "kiss-and-coat," which is characteristic of a broad variety of cell types that undergo regulated exocytosis. Kiss-and-coat exocytosis entails prolonged maintenance of a dilated fusion pore and assembly of actin filament (F-actin) coats around the exocytosing secretory vesicles followed by direct retrieval of some fraction of the emptied vesicle membrane. We propose that assembly of the actin coats results from the union of the secretory vesicle membrane and PM and that this compartment mixing represents a general mechanism for generating local signals via directed membrane fusion.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Sokac AM,Bement WMdoi
10.1091/mbc.e05-10-0908keywords:
subject
Has Abstractpub_date
2006-04-01 00:00:00pages
1495-502issue
4eissn
1059-1524issn
1939-4586pii
E05-10-0908journal_volume
17pub_type
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