Abstract:
:Understanding morphogenesis is the ultimate multidisciplinary (ad)venture. Three-dimensional tissues are generated from the actions of genes, biochemical pathways, and cells that form multicellular networks and interact with their biomechanical environment. A comprehensive explanation of morphogenetic processes must encompass these different levels of analysis. A recent meeting in Kyoto on "Building the Body Plan: How Cell Adhesion, Signaling, and Cytoskeletal Regulation Shape Morphogenesis" highlighted recent advances in tackling this challenging problem.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Zallen JA,Yap ASdoi
10.1091/mbc.e09-12-1076subject
Has Abstractpub_date
2010-03-15 00:00:00pages
845-7issue
6eissn
1059-1524issn
1939-4586pii
E09-12-1076journal_volume
21pub_type
abstract::Tumor initiation and growth is associated with significant changes in the surrounding tissue. During carcinoma progression, a global stiffening of the extracellular matrix is observed and is interpreted as a signature of aggressive invasive tumors. However, it is still unknown whether this increase in matrix rigidity ...
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更新日期:2006-06-01 00:00:00
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doi:10.1091/mbc.e02-08-0510
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abstract::Type I interferons (IFN-alpha/beta) induce apoptosis in certain tumor cell lines but not others. Here we describe a mutation in STAT2 that confers an apoptotic effect in tumor cells in response to type I IFNs. This mutation was introduced in a conserved motif, PYTK, located in the STAT SH2 domain, which is shared by S...
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doi:10.1091/mbc.e06-09-0843
更新日期:2007-07-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e08-12-1219
更新日期:2009-07-01 00:00:00
abstract::The tight junction adaptor protein ZO-1 regulates intracellular signaling and cell proliferation. Its Src homology 3 (SH3) domain is required for the regulation of proliferation and binds to the Y-box transcription factor ZO-1-associated nucleic acid binding protein (ZONAB). Binding of ZO-1 to ZONAB results in cytopla...
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pub_type: 杂志文章
doi:10.1091/mbc.e05-06-0507
更新日期:2006-03-01 00:00:00
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doi:10.1091/mbc.E20-01-0067
更新日期:2020-07-15 00:00:00
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journal_title:Molecular biology of the cell
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更新日期:2015-12-15 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e02-10-0699
更新日期:2003-06-01 00:00:00
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journal_title:Molecular biology of the cell
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journal_title:Molecular biology of the cell
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
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更新日期:2014-08-15 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e02-08-0544
更新日期:2003-07-01 00:00:00