Abstract:
:Midkine (MK) is a product of a retinoic acid-responsive gene and a new heparin-binding growth/differentiation factor. The coding sequence of human MK was located on 1.5 kb DNA segment. The structure of the cloned human MK gene was determined and compared with that of the mouse gene. The coding sequence was divided into 4 exons, and each exon and exon-intron boundary was highly homologous to those of the mouse. Furthermore, 170 bases in the upstream region of the putative transcription initiation sites and 3 blocks of 200-350 bases in regions further upstream were highly conserved. These sequences are likely to be involved in developmentally regulated expression of MK.
journal_name
J Biochemjournal_title
Journal of biochemistryauthors
Uehara K,Matsubara S,Kadomatsu K,Tsutsui J,Muramatsu Tdoi
10.1093/oxfordjournals.jbchem.a123797keywords:
subject
Has Abstractpub_date
1992-05-01 00:00:00pages
563-7issue
5eissn
0021-924Xissn
1756-2651journal_volume
111pub_type
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