Abstract：
:Celiac disease is manifested by an enteropathy caused by intolerance to gluten, a family of proteins found in wheat and other cereals. Following intestinal T-cell activation in predisposed individuals, different inflammatory mechanisms are triggered under the control of the cytokine balance including those with a pro-inflammatory Th1 pattern such as IFNgamma, TNFalpha, IL-15 and IL-18; and regulatory cytokines such as TGFbeta and IL-10. These cytokines, besides increasing the intensity of the activation and the number of immune cells within the intestinal mucosa, regulate the activity of epithelial growth factors and metalloproteinases, a group of molecules involved in the maintenance and turnover of the intestinal mucosa structure; in inflammatory conditions, they also induce the intestinal lesion responsible for malabsorption syndrome.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
León AJ,Garrote JA,Arranz Edoi
10.1157/13080220keywords:
subject
Has Abstractpub_date
2005-10-15 00:00:00pages
508-16issue
13eissn
0025-7753issn
1578-8989pii
S0025-7753(05)72094-7journal_volume
125pub_type
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