[Immunohistochemical study of inflammatory infiltrates in minor salivary glands in Sjögren's syndrome and other autoimmune diseases].

Abstract:

BACKGROUND:A study of the phenotype, activation and adhesive cells factors and cytokines in minor salivary glands in patients with primary Sjögren's syndrome (pSS), secondary Sjögren's syndrome (sSS) and autoimmune diseases (AD) without Sjögren's syndrome. PATIENTS AND METHODS:We have studied the minor salivary glands in 30 patients with pSS, 30 patients with sSS, 19 patients with AD without SS and 18 controls, using immunohistochemical techniques to analyze the molecular expression of CD3, CD4, CD8, CD20, CD25, CD14, CD56, CD11a, CDw50 (ICAM-3), HLA-DR, IL-1, TNF-alpha and IFN-gamma in lymphocytic infiltration and epithelial cells. RESULTS:Phenotype features were similar in patients with pSS and sSS, except that CD20+ lymphocyte expression was significantly higher in the sSS group (p = 0.023). The patients affected by AD without SS had activated lymphocytes in minor salivary glands in a similar manner to patients affected by pSS and sSS. No significant differences were found in HLA-DR expression in epithelial cells. We found unusual CD25 expression in epithelial cells in patients with SS but not in patients with AD without SS. The differences between pSS and sSS are related to SS theoretical time development and to immunosuppressive treatments. CONCLUSIONS:The immunohistochemical pattern of minor salivary glands is similar in patients with pSS and sSS. Patients with AD are likely to develop immunological changes in minor salivary glands attributable to activated lymphocytes.

journal_name

Med Clin (Barc)

journal_title

Medicina clinica

authors

Tomás S,Coll J,Reth P,Corominas JM

subject

Has Abstract

pub_date

1998-11-28 00:00:00

pages

681-6

issue

18

eissn

0025-7753

issn

1578-8989

journal_volume

111

pub_type

杂志文章
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    doi:

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    doi:

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  • [Surveillance of nosocomial infection at a regional++ hospital. Results of incidence and prevalence studies in a 2 years' experience].

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    doi:

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  • [Folic acid ingestion and associated factors in adult women 15-44 years of age in the Valencian Community].

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    doi:

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  • [The clinical significance of culturing Toxoplasma gondii on blood and other organic media].

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    pub_type: 杂志文章

    doi:

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  • [Preventable adverse drug events in hospitalized patients].

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