Abstract:
BACKGROUND:A study of the phenotype, activation and adhesive cells factors and cytokines in minor salivary glands in patients with primary Sjögren's syndrome (pSS), secondary Sjögren's syndrome (sSS) and autoimmune diseases (AD) without Sjögren's syndrome. PATIENTS AND METHODS:We have studied the minor salivary glands in 30 patients with pSS, 30 patients with sSS, 19 patients with AD without SS and 18 controls, using immunohistochemical techniques to analyze the molecular expression of CD3, CD4, CD8, CD20, CD25, CD14, CD56, CD11a, CDw50 (ICAM-3), HLA-DR, IL-1, TNF-alpha and IFN-gamma in lymphocytic infiltration and epithelial cells. RESULTS:Phenotype features were similar in patients with pSS and sSS, except that CD20+ lymphocyte expression was significantly higher in the sSS group (p = 0.023). The patients affected by AD without SS had activated lymphocytes in minor salivary glands in a similar manner to patients affected by pSS and sSS. No significant differences were found in HLA-DR expression in epithelial cells. We found unusual CD25 expression in epithelial cells in patients with SS but not in patients with AD without SS. The differences between pSS and sSS are related to SS theoretical time development and to immunosuppressive treatments. CONCLUSIONS:The immunohistochemical pattern of minor salivary glands is similar in patients with pSS and sSS. Patients with AD are likely to develop immunological changes in minor salivary glands attributable to activated lymphocytes.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Tomás S,Coll J,Reth P,Corominas JMsubject
Has Abstractpub_date
1998-11-28 00:00:00pages
681-6issue
18eissn
0025-7753issn
1578-8989journal_volume
111pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract::The association of deep vein thrombosis with systemic necrotizing vasculitis is infrequent. Herein are referred two patients with microscopic polyarteritis and one patient with overlap syndrome who developed deep vein thrombosis which complicated in two cases with pulmonary embolism. The clinical features and the path...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1993-12-11 00:00:00
abstract:BACKGROUND:To determine the frequency and the type of adrenal steroidogenic abnormalities in hirsute women. SUBJECTS AND METHODS:ACTH test was performed during follicular phase in 127 hirsute and 40 normal (control) women. Before ACTH injection we measured in serum by RIA: 17-OH-pregnenolone (17-OH-P5), 17-OH-progeste...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1998-02-14 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This study was aimed to verify whether it is possible to detect at hospital admission, by means of INTERMED, pneumonology patients at risk of "complexity" and of specialized psychosocial intervention. PATIENTS AND METHOD:With the Spanish version of INTERMED (for detection of risk for complexit...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(08)75487-3
更新日期:2008-11-29 00:00:00
abstract::The case of a patient with the diagnosis of essential thrombocythemia is presented. Following treatment with melphalan during three years the patient presented clinical and radiologic data of pulmonary fibrosis. Thoracotomy with lung biopsy histologically proving fibrosis was performed. The patient developed a true hi...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-23 00:00:00
abstract::Epstein-Barr virus (EBV) infection is ubiquitous and may result in multiple and widely different clinical features; the most common of these is infectious mononucleosis (IM). Recently, a group of patients has been included in the chronic EBV infection syndrome (EBVIS), with a sustained nonspecific syndrome consisting ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1989-04-29 00:00:00
abstract:OBJECTIVES:To analyze the results, efficacy and safety of unilateral microelectrode guided pallidotomy for the treatment of advanced Parkinson's disease, three months and one year after surgery. PATIENTS AND METHODS:23 patients with advanced Parkinson's disease (mean age 58.9 years and mean disease duration 14.4 years...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:2000-02-19 00:00:00
abstract::Heart failure (HF) is a cardiovascular disease with a permanent increase in prevalence, incidence and mortality. Current optimal therapies for HF are effective only for slowing, but not stopping, its progression. HF-related mortality is high, even at the time of the disease onset. Approximately 40% of HF-attributable ...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/s0025-7753(07)72555-1
更新日期:2007-02-24 00:00:00
abstract:BACKGROUND:Advanced atrioventricular block (AB) during acute myocardial infarction (AMI), characterizes a high-risk subgroup of patients. Our aim was to determine the prognostic significance of AB and its possible peculiarities in relation to infarction localization and/or the thrombolytic therapy. PATIENTS AND METHOD...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(00)71282-6
更新日期:2000-03-11 00:00:00
abstract:BACKGROUND:Recent advances in sensitivity and specificity of hormone immunoanalysis and their automatization have brought about changes in clinical laboratories that led us to review the need for some endocrine dynamic tests. The specific aim of this study was to determine the basal cortisol values predicting a normal ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(02)72415-9
更新日期:2002-04-06 00:00:00
abstract:BACKGROUND:Self-care of health problems including self-medication, constitutes the most frequent response to the most common acute symptoms in several studies carried out in other countries. Indeed there are few data concerning the scope of self-care in Spain. METHODS:A telephone survey was carried out by a questionna...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1992-10-10 00:00:00
abstract::The dual antiplatelet therapy with acetylsalicylic acid and clopidogrel has been the mainstay of both acute and chronic phase coronary artery disease, reducing importantly the risk of adverse events. Despite a correct compliance, a non-negligible rate of adverse events still happens. New compounds, with improved prope...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/j.medcli.2013.12.006
更新日期:2014-12-09 00:00:00
abstract:BACKGROUND:To evaluate the fat consumption and main sources of specific fatty acids in adults from the south and north of Spain. SUBJECTS AND METHODS:Dietary data from 25,816 women and 15,635 men, aged 29-69 years, participants in the European Prospective Study on Cancer and Nutrition (EPIC) recruited in the north (As...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1999-02-06 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Our objective was to analyze those factors predisposing to delirium in patients older than 84 years who were admitted because of hip fracture. We also compared the prevalence of delirium in this population with a younger group. PATIENTS AND METHOD:One hundred and thirty patients (mean age 91.8...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13073940
更新日期:2005-04-16 00:00:00
abstract:BACKGROUND:Given that Lyme's disease and HIV infection may present with similar clinical symptoms and that the serologic tests for the determination of antibodies against Borrelia burgdorferi present frequent false positives, the presence of antibodies against B. burgdorferi in patients with HIV in different evolutive ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1993-07-03 00:00:00
abstract:BACKGROUND AND OBJECTIVE:A good metabolic control of patients with type 2 diabetes mellitus (DM2) will likely contribute to a decrease of their cardiovascular (CV) risk. Our aim was (1) to evaluate the degree of metabolic control with regard to glycemia, lipidemia and blood pressure (BP) and (2) to describe the prevale...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(03)73735-x
更新日期:2003-04-05 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Direct oral anticoagulants (DOACs) require dose adjustment according to estimated clearance creatinine (eClCr) using the Cockcroft-Gault (CG) equation. There are discrepancies with the equations that estimate glomerular filtration rate (eGFR). We analyse how the use of the CKD-EPI and MDRD-4 ID...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2017.06.003
更新日期:2018-02-09 00:00:00
abstract:BACKGROUND:The most appropriate methods for surveillance of nosocomial infection (NI) in hospitals with less than 250 beds remain to be elucidated. The aims of this study were to investigate the differences between the results found in a study in incidence (IS) and in another concerning prevalence (PS) carried out in a...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1993-01-16 00:00:00
abstract:BACKGROUND:A low folic acid (FA) intake may increase the risk of neural tube defects (NTD). We estimated the proportion of women with a FA intake < 400 micrograms/day, at the Valencian Region, exploring those factors associated with a FA intake < 400 micrograms/day. SUBJECTS AND METHOD:Daily FA intake was estimated fo...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(00)71316-9
更新日期:2000-03-25 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Strategies to improve the efficiency of bronchoalveolar lavage (BAL) are needed. We conducted a study to establish the diagnostic value of BAL in patients with hematological malignancies and pulmonary infiltrates. PATIENTS AND METHODS:The correlation of cytologic and flow cytometric study of ...
journal_title:Medicina clinica
pub_type: 临床试验,杂志文章
doi:10.1016/j.medcli.2016.10.045
更新日期:2017-04-07 00:00:00
abstract:BACKGROUND:Given the importance of knowing the corporal composition according to the model of the four components (fat, mineral, fat free and aqueous) the same was calculated in 220 women and 130 men, considered as normal, between the ages of 15 and 49. METHODS:The corporal components were determined with double energ...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1992-03-28 00:00:00
abstract::Bile acids play a fundamental role in the degradation and absorption of intestinal lipids. The primary ones are cholic acid and chenodeoxycholic acid which are synthesized from cholesterol in the liver and conjugate with taurine and glycine amino acids. The secondary bile acids are derived from the primary ones by the...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1979-04-10 00:00:00
abstract::A 52 year old male presenting chronic myeloid leukemia (CML) Philadelphia chromosome positive (Ph) four years after the diagnosis of a non Hodgkin's lymphoma is described. The patient had received high total doses of alkylating drugs (cyclophosphamide and chlorambucil) as part of chemotherapy treatment for a diffuse m...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1992-06-20 00:00:00
abstract:BACKGROUND AND OBJECTIVE:We aimed to evaluate the prognostic impact of the degree and time-point of arterial recanalization during the first 24h after tPA administration in patients with acute middle cerebral artery (MCA) occlusions. PATIENTS AND METHOD:We prospectively studied consecutive ischemic stroke patients tre...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2008.06.029
更新日期:2009-05-02 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The smoke fume, principal factor in the development of lung cancer, causes the expression of certain cytokines, including interleukin 4, 6, 8 and 10, which may act by inhibiting apoptosis and interfere cellular repair mechanisms and angiogenesis. To determine the possible relationship between g...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2013.07.034
更新日期:2014-08-04 00:00:00
abstract:BACKGROUND:Description of measures of secondary prevention and of health related quality of life one year after the intervention in patients undergoing coronary artery bypass surgery. PATIENTS AND METHOD:One year follow up prospective study in patients undergoing first coronary bypass surgery without associated proced...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/s0025-7753(01)71785-x
更新日期:2001-02-24 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the value of the Toxoplasma gondii culture in blood and in other organic fluids in HIV positive and negative patients. METHODS:Retrospective analysis (October 1990-May 1992) was carried out including all patients with positive cultures for T. gondii admitted to the Hos...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To determine the incidence of adverse drug events (ADE) in hospitalized patients, identify those that were potentially preventable, and asses the drug classes involved, the clinical symptoms and the type of medication errors that led to the preventable ADE. PATIENTS AND METHOD:An observational...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1157/13083875
更新日期:2006-01-28 00:00:00
abstract:BACKGROUND:In the context of the COVID-19 pandemic the risk of misdiagnosis of other causes of respiratory infection is likely. In this work we aim to describe the clinical characteristics, treatment and outcome of pneumococcal infection in COVID-19 patients. PATIENTS AND METHODS:Every COVID-19 patient presenting with...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:10.1016/j.medcli.2020.05.022
更新日期:2020-12-11 00:00:00
abstract::We report 3 patients with chronic myeloproliferative syndromes and active tuberculous infection. The first patient had chronic myelocytic leukemia. In this patient, primary tuberculosis was localized in the lung. In spite of tuberculostatic treatment, he developed laterocervical lymphadenopathy and a tuberculous absce...
journal_title:Medicina clinica
pub_type: 杂志文章
doi:
更新日期:1990-04-21 00:00:00
abstract::We performed a systematic review to assess the efficacy and safety of extracorporeal albumin dialysis systems in patients with liver failure. After screening 436 references, 10 controlled trials were detected. The analyzed interventions were MARS, Prometheus and Biologic-DT. Efficacy was proven by a reduction in bilir...
journal_title:Medicina clinica
pub_type: 杂志文章,评审
doi:10.1016/j.medcli.2010.01.032
更新日期:2011-04-23 00:00:00