IL-2-activated cord blood mononuclear cells.

abstract：BACKGROUND AIMS:Traditionally, stem cell therapy for myocardial infarction (MI) has been administered as a single treatment in the acute or subacute period after MI. These time intervals coincide with marked differences in the post-infarct myocardial environment, raising the prospect that repeat cell dosing could provi...

journal_title：Cytotherapy

authors： Richardson JD,Psaltis PJ,Frost L,Paton S,Carbone A,Bertaso AG,Nelson AJ,Wong DT,Worthley MI,Gronthos S,Zannettino AC,Worthley SG

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Hematopoietic progenitor cells (HPC) circulate at high levels at birth and disappear rapidly afterwards, but the underlying mechanism it is not known. The aim of this study was to assess circulating HPC in cord blood at different gestational ages and shortly after birth and concomitantly study the biologic m...

journal_title：Cytotherapy

authors： Gonzalez S,Amat L,Azqueta C,Madrigal JA,Laïlla JM,Garcia J,Querol S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Retroviral vectors are regularly used to transduce stem cells and their derivatives for experimental and therapeutic purposes. Because these vectors integrate semi-randomly into the cellular genome, analysis of integranated retroviral DNA/host cell DNA junctions (IHJ) facilitates clonality studies of engraft...

journal_title：Cytotherapy

authors： Pule MA,Rousseau A,Vera J,Heslop HE,Brenner MK,Vanin EF

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Adipose tissue contains a stromal vascular fraction that can be easily isolated and provides a rich source of adipose tissue-derived mesenchymal stem cells (ASC). These ASC are a potential source of cells for tissue engineering. We studied whether the yield and growth characteristics of ASC were affected by ...

journal_title：Cytotherapy

authors： Oedayrajsingh-Varma MJ,van Ham SM,Knippenberg M,Helder MN,Klein-Nulend J,Schouten TE,Ritt MJ,van Milligen FJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Adipose-derived stromal cells (ASCs) are a promising new therapeutic option for patients with acute myocardial infarction (AMI). Previously, we found that ASCs coupled to antibody-targeted microbubbles (StemBells [StBs]) improved cardiac function when administered intravenously 7 days post-AMI in rats. In th...

journal_title：Cytotherapy

authors： Emmens RW,Oedayrajsingh-Varma M,Woudstra L,Kamp O,Meinster E,van Dijk A,Helder MN,Wouters D,Zeerleder S,van Ham SM,de Jong N,Niessen HW,Juffermans LJ,Krijnen PA

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AIMS:Endoscopy is the gold standard for the diagnosis and follow-up of patients with Crohn disease (CD). However, a less invasive approach is now being sought for the management of these patients. The objective of this study was to examine whether (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (...

journal_title：Cytotherapy

authors： Kuwaki K,Mitsuyama K,Kaida H,Takedatsu H,Yoshioka S,Yamasaki H,Yamauchi R,Fukunaga S,Abe T,Tsuruta O,Torimura T

更新日期：2016-02-01 00:00:00

abstract：:The efficacy of cord blood (CB) transplantation is limited by the low cell dose available. Low cell doses at transplant are correlated with delayed engraftment, prolonged neutropenia and thrombocytopenia and elevated risk of graft failure. To potentially improve the efficacy of CB transplantation, approaches have been...

journal_title：Cytotherapy

authors： Robinson S,Niu T,de Lima M,Ng J,Yang H,McMannis J,Karandish S,Sadeghi T,Fu P,del Angel M,O'Connor S,Champlin R,Shpall E

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:When stem-cell grafts are infused into the venous circulation and stem/progenitor cells egress from BM, pulmonary capillary beds are the first microcirculation site that they encounter. This provides the potential for circulating progenitor cells to be trapped in the pulmonary circulation. METHODS:We compar...

journal_title：Cytotherapy

authors： Watanabe T,Kajiume T,Takaue Y,Kawano Y,Kanamaru S,Okamura S,Onishi T,Suzuya H,Nakagawa R,Kuroda Y,Talmadge JE

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AIMS:Adipose tissue has therapeutic potential for spinal cord injury (SCI) because it contains multipotent cells known as adipose-derived stem/stromal cells (ASCs). In this study, we attempted intravenous ASC transplantation in rats with SCI to examine the effect on functional recovery. METHODS:ASCs (2.5 × ...

journal_title：Cytotherapy

authors： Ohta Y,Hamaguchi A,Ootaki M,Watanabe M,Takeba Y,Iiri T,Matsumoto N,Takenaga M

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Transplantation of mesenchymal stem cells (MSC) in rodent models has proved to be an effective therapeutic approach for spinal cord injury (SCI). However, further studies in primate models are still needed before clinical application of MSC to patients. METHODS:MSC were isolated from rhesus monkey BM and in...

journal_title：Cytotherapy

authors： Deng YB,Liu XG,Liu ZG,Liu XL,Liu Y,Zhou GQ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The mechanism of platelet recovery after hematopoietic stem cell transplantation and the factors that influence its time-course are not fully understood. Rapid hematopoietic recovery results in a reduction of transplantation-related complications. In the present study, we questioned and analyzed whether ther...

journal_title：Cytotherapy

authors： Woo KS,Goh RY,Kim SH,Kwon HC,Kim HJ,Lee YH,Han JY

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSC) are of clinical interest for their potential use in regenerative medicine and immunotherapy. Originally derived from bone marrow (BM), MSC have now been isolated from most tissues, including umbilical cord (UC) and UC blood (UCB). If MSC from UC are biologically equivalent to ...

journal_title：Cytotherapy

authors： Girdlestone J,Limbani VA,Cutler AJ,Navarrete CV

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Identification of HLA class I-restricted CMV epitopes, and the subsequent synthesis of HLA class I-peptide tetrameric complexes, have provided investigators with an important tool for visualising and quantifying the precise in vivo CTL response to CMV reactivation following stem cell transplantation. In conj...

journal_title：Cytotherapy

authors： Chen FE,Aubert G,Travers P,Dodi IA,Madrigal JA

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSC) have shown diverse therapeutic potential. While characterization of human and mouse MSC has seen significant advances, rat bone marrow-derived MSC (rBM-MSC) remain under-characterized. We detail the isolation, expansion, differentiation, and detailed immunocharacterization of ...

journal_title：Cytotherapy

authors： Harting M,Jimenez F,Pati S,Baumgartner J,Cox C Jr

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AIMS:Umbilical cord blood transplantation (UCBT) is increasingly used to treat acute leukemias. UCB units are thawed and infused in their entirety at transplant, precluding later use as immunotherapy to prevent or treat leukemia relapse. METHODS:We developed a device that selectively thaws only 1 mL of the ...

journal_title：Cytotherapy

authors： Vasu S,Berg M,Davidson-Moncada J,Tian X,Cullis H,Childs RW

更新日期：2015-11-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial endothelial hyperproliferation and dysfunction. Restoration of endothelial function is a common goal of available treatments. In the present study, human adipose-derived mesenchymal stromal cells (ASCs) were co-cultured with monocrotaline pyr...

journal_title：Cytotherapy

authors： Wang P,Zhang C,Li J,Luo L,Zhang S,Dong F,Tang Z,Ni S

更新日期：2019-04-01 00:00:00

abstract：:Infusion of viral-specific T cells (VSTs) is an effective treatment for viral infection after stem cell transplant. Current manufacturing approaches are rapid, but growth conditions can still be further improved. To optimize VST cell products, the authors designed a high-throughput flow cytometry-based assay using 40 ...

journal_title：Cytotherapy

authors： Lazarski CA,Datar AA,Reynolds EK,Keller MD,Bollard CM,Hanley PJ

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AIMS:The therapeutic potential of human mesenchymal stromal cells (MSCs) has generated considerable interest in a wide variety of areas. MSC banking is feasible, but the optimal technique of cryopreservation remains to be determined. METHODS:To reduce dimethyl sulfoxide (DMSO) concentration in cryopreservat...

journal_title：Cytotherapy

authors： Briquet A,Halleux A,Lechanteur C,Beguin Y

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Hematopoietic progenitor stem cells (HPSC) are a specialized transfusion product used for transplantation. Microbial contamination may occur during harvest or subsequent manipulation of these cells. The same difficulties in ensuring a safe, sterile, final product are faced in the preparation of other cell-th...

journal_title：Cytotherapy

authors： Lowder JN,Whelton P

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AIMS:Cutaneous wound management is a major health problem and imposes a huge economic burden worldwide. Previous studies have demonstrated that wound healing is a highly coordinated process including epithelialization, angiogenesis, remodeling and scarring. This progression requires self-renewal, preservatio...

journal_title：Cytotherapy

authors： Chen X,Yang R,Wang J,Ruan S,Lin Z,Xin Q,Yang R,Xie J

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AIMS:Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide. Developing effective protocols for the administration of mesenchymal stromal cells (MSCs) is a promising therapeutic strategy to treat TBI. It is important to develop alternatives to direct parenchymal injection at the...

journal_title：Cytotherapy

authors： Bonilla C,Zurita M,Aguayo C,Rodríguez A,Vaquero J

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AIMS:Enumeration of viable CD34(+) cells provides critical information for the bone marrow (BM) transplant physician. The single-platform ISHAGE protocol is the most reliable method currently available to quantitate accurately this important subset of cells. Previous studies have shown that 5 CD34(+) cells/m...

journal_title：Cytotherapy

authors： Sutherland DR,Nayyar R,Acton E,Giftakis A,Dean S,Mosiman VL

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSCs) have been applied to patients in cell therapy for various diseases. Recently, we introduced a novel MSC separation filter device which could yield approximately 2.5-fold more MSCs from bone marrow in a closed system compared with the conventional open density gradient ce...

journal_title：Cytotherapy

authors： Otsuru S,Hofmann TJ,Raman P,Olson TS,Guess AJ,Dominici M,Horwitz EM

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Very few tumoral Ags have yet been isolated in NHL B cells. It is nevertheless possible to use whole tumor cells as a source of tumor Ags. We describe the purification of large numbers of human NHL B cells directly from lymph node or spleen biopsies, and different preparations allowing their use in a clinica...

journal_title：Cytotherapy

authors： Lui G,Manches O,Chaperot L,Ducrot T,Molens JP,Sotto JJ,Bensa JC,Plumas J

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AIMS:Multiple steps are required to produce chimeric antigen receptor (CAR)-T cells, involving subset enrichment or depletion, activation, gene transduction and expansion. Open processing steps that increase risk of contamination and production failure are required. This complex process requires skilled pers...

journal_title：Cytotherapy

authors： Zhu F,Shah N,Xu H,Schneider D,Orentas R,Dropulic B,Hari P,Keever-Taylor CA

更新日期：2018-03-01 00:00:00

abstract：:There is a widely held expectation of clinical advance with the development of gene and cell-based therapies (GCTs). Yet, establishing benefits and risks is highly uncertain. We examine differences in decision-making for GCT approval between jurisdictions by comparing regulatory assessment procedures in the United Sta...

journal_title：Cytotherapy

authors： Coppens DGM,de Wilde S,Guchelaar HJ,De Bruin ML,Leufkens HGM,Meij P,Hoekman J

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Traditionally, following high-dose therapy (HDT), unmanipulated autologous PBPC are infused. Alternatively, purified CD34+ cells can now be obtained by immunomagnetic separation using the CliniMACS device. Limited data currently exist examining hemopoietic recovery with such cells. METHODS:Ten patients with...

journal_title：Cytotherapy

authors： Prince HM,Wall D,Rischin D,Toner GC,Seymour JF,Blakey D,Haylock D,Simmons P,Wolf M,Januszewicz EH,Westerman D,Richardson G,Scarlett J,Briggs P

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AIMS:We have confirmed that aortic aneurysm (AA) can be regressed by the administration of bone marrow-derived mesenchymal stromal cells (BM-MSCs). We investigated the kinetics of signaling pathways in AA following treatment with BM-MSCs. METHODS:Angiotensin II-infused apolipoprotein E-deficient mice were t...

journal_title：Cytotherapy

authors： Yamawaki-Ogata A,Oshima H,Usui A,Narita Y

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AIMS:Stem cells derived from human adipose tissue (ASC) have the capacity for renewal, are easily obtained and have plasticity properties that allow them to differentiate into several cell types, including osteoblast cells. With the aim of understanding the issue of the osteogenic process and finding reliabl...

journal_title：Cytotherapy

authors： Giusta MS,Andrade H,Santos AV,Castanheira P,Lamana L,Pimenta AM,Goes AM

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) have been shown to be a promising candidate for tissue regeneration and cancer therapy. However, their therapeutic potential against chemotherapy-induced side-effects remains unclear. METHODS:We treated murine Lewis lung carcinoma (LLC) and xenograft human colon tumors w...

journal_title：Cytotherapy

authors： Di GH,Jiang S,Li FQ,Sun JZ,Wu CT,Hu X,Duan HF

更新日期：2012-04-01 00:00:00