The evolving role of acute stroke imaging in intravenous thrombolytic therapy: patient selection and outcomes assessment.

Abstract:

:In early trials of thrombolysis, unenhanced CT was used to exclude patients with brain hemorrhage or large infarctions but was insensitive to stroke pathophysiology or early signs of cerebral ischemia or infarction. Currently, CT angiography, CT perfusion, and MR imaging can provide information about stroke mechanisms and prognosis, quantify penumbral tissue, and support risk stratification and patient selection. This article reviews the role of neuroimaging in the original intravenous thrombolytic trials, current application of these technologies, and the potential future role of imaging to extend the time window for thrombolysis and to augment therapeutic success.

journal_name

Neuroimaging Clin N Am

authors

Sims J,Schwamm LH

doi

10.1016/j.nic.2005.06.001

keywords:

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

421-40, xii

issue

2

eissn

1052-5149

issn

1557-9867

pii

S1052-5149(05)00040-7

journal_volume

15

pub_type

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