Abstract：
:Assessment of the oxygenation status of brain tumors has been studied increasingly with imaging techniques in light of recent advances in oncology. Tumor oxygen tension is a critical factor influencing the effectiveness of radiation and chemotherapy and malignant progression. Hypoxic tumors are resistant to treatment, and prognostic value of tumor oxygen status is shown in head and neck tumors. Strategies increasing the tumor oxygenation are being investigated to overcome the compromising [figure: see text] effect of hypoxia on tumor treatment. Administration of nicotinamide and inhalation of various high oxygen concentrations have been implemented. Existing methods for assessment of tissue oxygen level are either invasive or insufficient. Accurate and noninvasive means to measure tumor oxygenation are needed for treatment planning, identification of patients who might benefit from oxygenation strategies, and assessing the efficacy of interventions aimed to increase the radiosensitivity of tumors. Of the various imaging techniques used to assess tissue oxygenation, MR spectroscopy and MR imaging are widely available, noninvasive, and clinically applicable techniques. Tumor hypoxia is related closely to insufficient blood flow through chaotic and partially nonfunctional tumor vasculature and the distance between the capillaries and the tumor cells. Information on characteristics of tumor vasculature such as blood volume, perfusion, and increased capillary permeability can be provided with MR imaging. MR imaging techniques can provide a measure of capillary permeability based on contrast enhancement and relative cerebral blood volume estimates using dynamic susceptibility MR imaging. Blood oxygen level dependent contrast MR imaging using gradient echo sequence is intrinsically sensitive to changes in blood oxygen level. Animal models using blood oxygen level-dependent contrast imaging reveal the different responses of normal and tumor vasculature under hyperoxia. Normobaric hyperoxia is used in MR studies as a method to produce MR contrast in tissues. Increased T2* signal intensity of brain tissue has been observed using blood oxygen level-dependent contrast MR imaging. Dynamic blood oxygen level-dependent contrast MR imaging during hyperoxia is suggested to image tumor oxygenation. Quantification of cerebral oxygen saturation using blood oxygen level-dependent MR imaging also has been reported. Quantification of cerebral blood oxygen saturation using MR imaging has promising clinical applications; however, technical difficulties have to be resolved. Blood oxygen level dependent MR imaging is an emerging technique to evaluate the cerebral blood oxygen saturation, and it has the potential and versatility to assess oxygenation status of brain tumors. Upon improvement and validation of current MR techniques, better diagnostic, prognostic, and treatment monitoring capabilities can be provided for patients with brain tumors.
journal_name
Neuroimaging Clin N Amjournal_title
Neuroimaging clinics of North Americaauthors
Yetkin FZ,Mendelsohn Ddoi
10.1016/s1052-5149(02)00029-1keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
537-52issue
4eissn
1052-5149issn
1557-9867pii
S1052-5149(02)00029-1journal_volume
12pub_type
杂志文章,评审abstract：:Functional MR imaging (fMRI) is being used increasingly to explore the human central auditory system. The considerable background noise produced by echo-planar imaging (EPI) and other fMRI sequences, however, interferes in an unpredictable way with the experimental stimuli. Several approaches exist to overcome this pr...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2001-05-01 00:00:00
abstract：:Diffusion imaging is a functional MR imaging tool that creates tissue contrast representative of the random, microscopic translational motion of water molecules within human body tissues. Long considered a cornerstone MR imaging sequence for brain imaging, diffusion-weighted imaging (DWI) increasingly is used for head...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2020.04.001
更新日期：2020-08-01 00:00:00
abstract：:The role for neuroimaging in the management of patients with tremor is gradually increasing, particularly with respect to stereotactic neurosurgery and deep brain stimulation where less than 2-mm tolerance is required for accurate electrode placement. The routine use of single photon emission CT technology to image th...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章
doi：10.1016/j.nic.2009.08.005
更新日期：2010-02-01 00:00:00
abstract：:Spontaneous intracranial hemorrhage is a commonly encountered neurologic emergency. Imaging plays important roles in both guiding the emergent stabilization of patients with ICH and in elucidating the etiology of the hemorrhage to prevent rebleeding. A thorough understanding of the factors that have an impact on immed...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2018.03.003
更新日期：2018-08-01 00:00:00
abstract：:This article presents the clinical and imaging aspects of some common and important orbital and optic pathway lesions occurring in childhood. Lesions that arise outside of and encroach on the orbit and visual pathways are included. Abnormalities intrinsic to the globe are covered elsewhere in this issue. ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1996-02-01 00:00:00
abstract：:Conventional neuroimaging is still the mainstay in the assessment of the acute, follow-up, and chronic settings of concussion and mild traumatic brain injury (mTBI). Computed tomography (CT) is preferred for the initial assessment of acute mTBI, repeat evaluation in acute mTBI with neurologic deterioration, and cautio...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2017.09.006
更新日期：2018-02-01 00:00:00
abstract：:Pyogenic spondylitis and discitis are usually seen following a recent infection or surgery. A septic embolus causes an infarcted area within the bone. Pyogenic spondylitis is characterized by edema, vascular leakage, and supportive inflammatory reaction characterized with polymorphonuclear leukocytes. In tuberculosis ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2015.01.011
更新日期：2015-05-01 00:00:00
abstract：:The neuroimaging of hydrocephalus from the perspective of the pediatric neurosurgeon is discussed. Processes with new developments in therapy and imaging are described, including congenital causes of hydrocephalus, unilateral hydrocephalus, trapped fourth ventricle, and benign external hydrocephalus. ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1999-02-01 00:00:00
abstract：:Recent advances in artificial intelligence (AI) and deep learning (DL) hold promise to augment neuroimaging diagnosis for patients with brain tumors and stroke. Here, the authors review the diverse landscape of emerging neuroimaging applications of AI, including workflow optimization, lesion segmentation, and precisio...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2020.07.003
更新日期：2020-11-01 00:00:00
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journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2008.03.009
更新日期：2008-08-01 00:00:00
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journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章
doi：10.1016/j.nic.2010.02.012
更新日期：2010-05-01 00:00:00
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journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1996-11-01 00:00:00
abstract：:This article presents the advantages and challenges of MR angiography of the intracranial and extracranial cerebral vasculature at 3.0 T with comparative assessment to 1.5 T approaches. The physical basis for the superiority of 3.0 T MR angiography is discussed in the context of evolving technological capabilities aff...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2006.03.002
更新日期：2006-05-01 00:00:00
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journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2005.06.001
更新日期：2005-05-01 00:00:00
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journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章
doi：10.1016/s1052-5149(03)00074-1
更新日期：2002-02-01 00:00:00
abstract：:By harnessing the versatility and soft tissue imaging capabilities of MR imaging alongside the unmatched sensitivity and biomolecular flexibility of PET, the potential to provide detailed multiparametric plaque characterization in the carotid arteries is clear. The ability to acquire simultaneous, and dynamic multimod...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2015.09.005
更新日期：2016-02-01 00:00:00
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journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2011.05.009
更新日期：2011-08-01 00:00:00
abstract：:Gadolinium (Gd)-enhanced MR imaging has greatly improved the understanding of the pathophysiology of multiple sclerosis (MS) and has provided robust outcome measures for monitoring MS activity. Modest correlation between the presence and extent of enhancement and the evolution of MS probably owes to the limited sensit...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2000-11-01 00:00:00
abstract：:The Resource-Based Relative Value Scale (RBRVS) has been the defining algorithm for professional reimbursement of medical services since its introduction in 1992. This article reviews the history of the RBRVS, with an emphasis on the integral involvement of the radiology and neuroradiology communities. Appropriate rei...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2012.04.008
更新日期：2012-08-01 00:00:00
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journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1994-02-01 00:00:00
abstract：:Spondylitis or infection of the spine is a spectrum of diseases involving the bone, disks, and/or ligaments. Because of a significant increase in the immunocompromised patient population, spinal infections are a growing and changing group of conditions, making the diagnosis based on imaging more challenging. Most case...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2015.01.007
更新日期：2015-05-01 00:00:00
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journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2009.08.015
更新日期：2009-11-01 00:00:00
abstract：:Magnetic resonance (MR) imaging, in addition to its excellent depiction of neuroanatomy, is being developed as a major technique for functional imaging of cerebrospinal fluid motion and for measurement of velocity, strain, and diffusional processes within the brain parenchyma. Functional MR imaging studies are reveali...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1995-02-01 00:00:00
abstract：:Viral infections of the brain and spinal cord cause significant morbidity and mortality in patients afflicted with AIDS. Debate continues over the specific mechanisms and pathways of how HIV-1 manifests itself in the brain and spinal cord. Attempts to predict which seropositive patients develop neurocognitive deficits...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1997-05-01 00:00:00
abstract：:Central nervous system (CNS) tuberculosis is frequently encountered in tropical countries. Imaging plays an important role in its recognition and in its differentiation from other similar conditions. Specific magnetic resonance techniques, such as magnetization transfer imaging, proton magnetic resonance spectroscopy,...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2011.07.004
更新日期：2011-11-01 00:00:00
abstract：:Surgical approaches to the skull base have seen significant evolution. The most practical approaches now use the concept of comprehensive integration of all phases of cranial base surgery, from modular disassembly of the craniofacial skeleton and tumor resection to a functional and aesthetic reconstruction. The improv...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:This content presents infectious and vascular spinal emergencies, including epidural abscess, nontraumatic epidural hematoma, vascular malformations, and spinal cord infarction. The spine is subjected to multiple potential insults, such as trauma, infection, ischemia, hemorrhage, tumor, inflammation, and degeneration....
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2010.07.006
更新日期：2010-11-01 00:00:00
abstract：:This article focuses on the indications for anterior cervical surgery, relevant surgical anatomy, a brief description of the technique of anterior surgery followed by a discussion of results and complications. It is hoped that the reader will achieve a better understanding for the clinical syndrome of cervical disc de...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1995-08-01 00:00:00
abstract：:Cryotherapy of the brain is an old and well-established technique of functional and resective neurosurgery. With the use of modern imaging techniques such as MR imaging, which is ideally suited for diagnosis, planning, and monitoring of an ablation procedure, cryotherapy can become a modern alternative to other ablati...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2001-11-01 00:00:00
abstract：:The etiology and types of intracranial vasculitis are described, along with a neuroimaging-oriented classification system. Specific entities are discussed in detail. The role of various modalities is defined, as well as a practical approach to diagnosis. ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1994-11-01 00:00:00
