Abstract：
:Overexpression of multi-drug resistant P-glycoprotein (Pgp) remains an important barrier to successful chemotherapy in cancer patients and impacts the pharmacokinetics of many important drugs. Pgp is also expressed on the luminal surface of brain capillary endothelial cells wherein Pgp functionally comprises a major component of the blood-brain barrier by limiting central nervous system penetration of various therapeutic agents. In addition, Pgp in brain capillary endothelial cells removes amyloid-beta from the brain. Several single photon emission computed tomography and positron emission tomography radiopharmaceutical have been shown to be transported by Pgp, thereby enabling the noninvasive interrogation of Pgp-mediated transport activity in vivo. Therefore, molecular imaging of Pgp activity may enable noninvasive dynamic monitoring of multi-drug resistance in cancer, guide therapeutic choices in cancer chemotherapy, and identify transporter deficiencies of the blood-brain barrier in Alzheimer's disease.
journal_name
Neuroimaging Clin N Amjournal_title
Neuroimaging clinics of North Americaauthors
Piwnica-Worms D,Kesarwala AH,Pichler A,Prior JL,Sharma Vdoi
10.1016/j.nic.2006.06.007subject
Has Abstractpub_date
2006-11-01 00:00:00pages
575-89, viiiissue
4eissn
1052-5149issn
1557-9867pii
S1052-5149(06)00074-8journal_volume
16pub_type
杂志文章,评审abstract：:Neurofibrillary pathology in Alzheimer's disease consists of paired helical filaments comprising tau protein. This pathology is correlated with dementia, but can appear in the first two decades of life. Extracellular amyloid β-protein arises through proteolytic processing of a transmembrane precursor, which involves t...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2011.11.003
更新日期：2012-02-01 00:00:00
abstract：:Surgical approaches to the skull base have seen significant evolution. The most practical approaches now use the concept of comprehensive integration of all phases of cranial base surgery, from modular disassembly of the craniofacial skeleton and tumor resection to a functional and aesthetic reconstruction. The improv...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:The salivary glands play an important role in digestion and oral hygiene, and give rise to a variety of benign and malignant pathologies. In suspected pathology, the goal of imaging is to confirm a lesion as being of salivary gland origin, narrow the list of differential considerations, define the extent of disease, a...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2018.01.001
更新日期：2018-05-01 00:00:00
abstract：:This article reviews the current status and trends in the treatment of primary gliomas, focusing predominantly on glioblastoma. It also discusses the current standard of care and new targeted agents currently under investigation. Furthermore, the concepts of pseudoprogression and pseudoresponse are introduced, which a...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2009.08.015
更新日期：2009-11-01 00:00:00
abstract：:Mild cognitive impairment (MCI), a major risk factor for dementia, has an amnestic subtype that has a high probability of progressing to Alzheimer's disease. The rate of progression may be predicted by the severity of memory impairment at baseline, the severity of hippocampal atrophy, and, possibly, the presence of an...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2005.09.010
更新日期：2005-11-01 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) has become a common tool for presurgical sensorimotor mapping, and is a significant preoperative asset for tumors located adjacent to the central sulcus. fMRI has changed surgical options for many patients. This noninvasive tool allows for easy display and integration with ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2014.07.003
更新日期：2014-11-01 00:00:00
abstract：:Central nervous system infections and sequelae in the pediatric population may present differently depending on the patient's stage of development. Infections contracted from conception through the neonatal period may affect central nervous system formation, whereas infections acquired later tend to cause parenchymal ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:Since acute stroke and transient ischemic attack (TIA) are disruptions of brain hemodynamics, perfusion neuroimaging might be of clinical utility. Recently, arterial spin labeling (ASL), a noncontrast perfusion method, has become clinically feasible. It has advantages compared to contrast bolus perfusion-weighted imag...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2011.01.003
更新日期：2011-05-01 00:00:00
abstract：:There are increasing applications and use of spectral computed tomography or dual-energy computed tomography (DECT) in neuroradiology and head and neck imaging in routine clinical practice. Part 1 of this 2-part review covered fundamental physical principles underlying DECT scanning and the different approaches for sc...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2017.03.003
更新日期：2017-08-01 00:00:00
abstract：:Neuroimaging is a potentially valuable tool to link individual differences in the human genome to structure and functional variations, narrowing the gaps in the casual chain from a given genetic variation to a brain disorder. Because genes are not usually expressed at the level of mental behavior, but are mediated by ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2014.09.005
更新日期：2015-02-01 00:00:00
abstract：:This article provides a brief description of cerebral arterial angiographic anatomy with special attention given to the deep nuclear structures and collateral supply as it relates to acute ischemic stroke. Illustrative angiography cases with the CT or MRI are provided. Illustrative cases of differential diagnoses of s...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1999-08-01 00:00:00
abstract：:Despite considerable research evidence demonstrating significant neurobiological alterations in psychiatric disorders, incorporating neuroimaging approaches into clinical practice remains challenging. There is an urgent need for biologically validated psychiatric disease constructs that can inform diagnostic algorithm...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2019.09.005
更新日期：2020-02-01 00:00:00
abstract：:Blood, cerebrospinal fluid, and extracellular fluid of the parenchyma form the fluid compartments of the brain with three interfaces between--the blood-brain interface, the CSF-brain interface, and the blood-CSF interface. These and other issues are discussed in this article. ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1998-08-01 00:00:00
abstract：:The etiology and types of intracranial vasculitis are described, along with a neuroimaging-oriented classification system. Specific entities are discussed in detail. The role of various modalities is defined, as well as a practical approach to diagnosis. ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1994-11-01 00:00:00
abstract：:The most feared complication after acute ischemic stroke is symptomatic or asymptomatic hemorrhagic conversion. Neuroimaging and clinical criteria are used to predict development of hemorrhage. Seizures after acute ischemic stroke or stroke-like symptoms from seizures are not common but may lead to confusion in the pe...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2018.06.007
更新日期：2018-11-01 00:00:00
abstract：:Gadolinium (Gd)-enhanced MR imaging has greatly improved the understanding of the pathophysiology of multiple sclerosis (MS) and has provided robust outcome measures for monitoring MS activity. Modest correlation between the presence and extent of enhancement and the evolution of MS probably owes to the limited sensit...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2000-11-01 00:00:00
abstract：:Because of its superior depiction of bone detail, CT is a useful tool in the characterization of CF deformities and presurgical planning. Modern CT scanners and workstations provide 2D techniques such as multiplanar reformats and 3D techniques, such as MIP and volume renderings, which may be used effectively in the di...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s1052-5149(03)00061-3
更新日期：2003-08-01 00:00:00
abstract：:One of the major pitfalls faced by physicians is a basic lack of understanding of the legal aspects of medical malpractice. It is the authors' hope that the brief review of the history of malpractice law provided here affords the radiologist insights that could prove helpful in understanding how one must conduct onese...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2012.05.012
更新日期：2012-08-01 00:00:00
abstract：:For over 20 years, conventional MR imaging has been used for assessing brain tumors. However, conventional MR imaging tends to underestimate the extent of the tumor, perhaps leading to suboptimal treatment. New MR imaging tools have been widely used to determine the grade, heterogeneity, and extent of brain tumors. Di...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章
doi：10.1016/j.nic.2011.01.010
更新日期：2011-02-01 00:00:00
abstract：:Oral cavity cancer comprises nearly 30% of all malignant tumors of the head and neck. After a definitive diagnosis has been made, imaging is essential for staging the primary tumor by evaluating submucosal spread and invasion of adjacent structures, and to identify nodal or distant metastasis. Oral cavity anatomy is o...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2012.08.004
更新日期：2013-02-01 00:00:00
abstract：:Different types of malformations share a dilated vein of Galen, but only one of them is a true vein of Galen aneurysmal malformation (VGAM). The optimal window of opportunity for treatment is between 4 and 5 years of months [corrected], because this allows the child to grow and mature. Heart failure and hydrocephalus ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2007.02.005
更新日期：2007-05-01 00:00:00
abstract：:In addition to its inability to predict pressure elevation accurately, head CTs done serially even at 12-hour intervals, cannot adequately portray the dynamic, sometimes rapid evolution (usually growth) of a traumatic hematoma. These limitations aside, CT scanning provides adequate imaging for rational surgical treatm...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章
doi：10.1016/s1052-5149(02)00013-8
更新日期：2002-05-01 00:00:00
abstract：:Biologic connectionism holds as its central tenet that the cognitive, behavioral, and motor functions of the brain are derived from the complex interconnections of simple neural processing units. Much can be learned about the human mind through the study of the brain's connections in normal and diseased states. This a...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2007.07.002
更新日期：2007-11-01 00:00:00
abstract：:Pyomyositis is the primary infection of the skeletal muscle. It is common in the tropics, but is increasingly being reported worldwide. It can affect immunocompromised and immunocompetent individuals. Staphylococcus aureus is the most common causative organism. Muscle histology and its culture remain the gold standard...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2011.07.011
更新日期：2011-11-01 00:00:00
abstract：:Interpreting CT or MR imaging examinations performed on patients with a history of middle ear, mastoid, or neurotologic surgery can be challenging. This is greatly simplified by knowing the surgical procedures used and the expected postoperative appearance. These are reviewed and illustrated in this article. Knowing t...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2009.06.005
更新日期：2009-08-01 00:00:00
abstract：:Evaluation of imaging studies of the cerebellum in inherited neurodegenerative disorders is aided by attention to neuroimaging patterns based on anatomic determinants, including biometric analysis, hyperintense signal of structures, including the cerebellar cortex, white matter, dentate nuclei, brainstem tracts, and n...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2016.03.007
更新日期：2016-08-01 00:00:00
abstract：:This article presents the clinical and imaging aspects of some common and important orbital and optic pathway lesions occurring in childhood. Lesions that arise outside of and encroach on the orbit and visual pathways are included. Abnormalities intrinsic to the globe are covered elsewhere in this issue. ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1996-02-01 00:00:00
abstract：:Acute disseminated encephalomyelitis (ADEM) is a monophasic demyelinating disease of the central nervous system typically affecting the gray and the white matter of the brain and spinal cord in multiple locations. In the acute stages, ADEM is characterized histologically by perivenous edema, demyelination, and infiltr...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2007.12.007
更新日期：2008-02-01 00:00:00
abstract：:Neoplastic and non-neoplastic lesions may involve the minor salivary glands. Tumors of minor salivary glands are commonly seen in the oral cavity. Malignant tumors are more common than benign minor salivary gland tumors. The most common malignant tumors are adenoid cystic carcinoma and mucoepidermoid carcinoma, and th...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2018.01.008
更新日期：2018-05-01 00:00:00
abstract：:The epidemic of cardiovascular disease across most of Asia is at a different stage from that in the West; the incidence and prevalence of stroke are increasing steadily, associated with nutritional changes and aging of the population. Epidemiologic data, crucial in combating stroke, have been relatively sparse in Asia...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2005.07.001
更新日期：2005-05-01 00:00:00
