Abstract：
:Neuroimaging is a potentially valuable tool to link individual differences in the human genome to structure and functional variations, narrowing the gaps in the casual chain from a given genetic variation to a brain disorder. Because genes are not usually expressed at the level of mental behavior, but are mediated by their molecular and cellular effects, molecular imaging could play a key role. This article reviews the literature using molecular imaging as an intermediate phenotype and/or biomarker for illness related to certain genetic alterations, focusing on the most common neurodegenerative disorders, Alzheimer's disease (AD) and Parkinson disease.
journal_name
Neuroimaging Clin N Amjournal_title
Neuroimaging clinics of North Americaauthors
Leite J,Hespanhol R,Buchpiguel CAdoi
10.1016/j.nic.2014.09.005subject
Has Abstractpub_date
2015-02-01 00:00:00pages
17-29issue
1eissn
1052-5149issn
1557-9867pii
S1052-5149(14)00085-9journal_volume
25pub_type
杂志文章,评审abstract：:The classic multiple sclerosis variants including Devic's neuromyelitis optica (NMO), Balo's concentric Sclerosis, Schilder's disease, and Marburg MS are both interesting and instructive from a disease pathophysiology perspective. Although rare, the variants are important as they often arise in the differential diagno...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2008.06.003
更新日期：2008-11-01 00:00:00
abstract：:Classical descriptions of the temporal bone are based on its five embryologically distinct osseous components: the petrous, tympanic, mastoid, squamous, and styloid portions. ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章
doi：10.1016/j.nic.2004.07.008
更新日期：2004-11-01 00:00:00
abstract：:The most feared complication after acute ischemic stroke is symptomatic or asymptomatic hemorrhagic conversion. Neuroimaging and clinical criteria are used to predict development of hemorrhage. Seizures after acute ischemic stroke or stroke-like symptoms from seizures are not common but may lead to confusion in the pe...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2018.06.007
更新日期：2018-11-01 00:00:00
abstract：:High resolution computed tomography has proved to be invaluable in the evaluation of the temporal bone, and demonstrates its bony anatomy in exquisite detail. Furthermore, the role of magnetic resonance imaging, especially with improving high resolution techniques, has continued to expand in the past decade. A thoroug...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1998-02-01 00:00:00
abstract：:Approximately 30,000 spinal injuries occur in the United States every year. Injuries to the spine and its contents affect predominately young, healthy individuals and are a major cause of disability, with significant socioeconomic consequences. The main cause for spinal injuries is blunt trauma, most commonly caused b...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2006.11.006
更新日期：2007-02-01 00:00:00
abstract：:Central nervous system infections and sequelae in the pediatric population may present differently depending on the patient's stage of development. Infections contracted from conception through the neonatal period may affect central nervous system formation, whereas infections acquired later tend to cause parenchymal ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:Spondylitis or infection of the spine is a spectrum of diseases involving the bone, disks, and/or ligaments. Because of a significant increase in the immunocompromised patient population, spinal infections are a growing and changing group of conditions, making the diagnosis based on imaging more challenging. Most case...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2015.01.007
更新日期：2015-05-01 00:00:00
abstract：:Different types of malformations share a dilated vein of Galen, but only one of them is a true vein of Galen aneurysmal malformation (VGAM). The optimal window of opportunity for treatment is between 4 and 5 years of months [corrected], because this allows the child to grow and mature. Heart failure and hydrocephalus ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2007.02.005
更新日期：2007-05-01 00:00:00
abstract：:Most articles in 1995 demonstrated a sensitivity of 100% and specificities of 90% to 98% in detecting carotid bifurcation stenosis using a combination of MR angiography and ultrasonography, reserving conventional angiography for cases of disparate stenosis with the noninvasive studies. Multiple reviews concluded that ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1996-11-01 00:00:00
abstract：:Evaluation of imaging studies of the cerebellum in inherited neurodegenerative disorders is aided by attention to neuroimaging patterns based on anatomic determinants, including biometric analysis, hyperintense signal of structures, including the cerebellar cortex, white matter, dentate nuclei, brainstem tracts, and n...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2016.03.007
更新日期：2016-08-01 00:00:00
abstract：:EEG-fMRI is capable of providing novel localizing information in a substantial proportion of patients with frequent epileptiform discharges, even at 1.5T, suggesting a potential clinical role. Increasing availability of equipment capable of providing good-quality intra-MR imaging EEG with relative ease should ensure a...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2004.04.009
更新日期：2004-08-01 00:00:00
abstract：:One of the major pitfalls faced by physicians is a basic lack of understanding of the legal aspects of medical malpractice. It is the authors' hope that the brief review of the history of malpractice law provided here affords the radiologist insights that could prove helpful in understanding how one must conduct onese...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2012.05.012
更新日期：2012-08-01 00:00:00
abstract：:Interpreting CT or MR imaging examinations performed on patients with a history of middle ear, mastoid, or neurotologic surgery can be challenging. This is greatly simplified by knowing the surgical procedures used and the expected postoperative appearance. These are reviewed and illustrated in this article. Knowing t...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2009.06.005
更新日期：2009-08-01 00:00:00
abstract：:There are increasing applications and use of spectral computed tomography or dual-energy computed tomography (DECT) in neuroradiology and head and neck imaging in routine clinical practice. Part 1 of this 2-part review covered fundamental physical principles underlying DECT scanning and the different approaches for sc...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2017.03.003
更新日期：2017-08-01 00:00:00
abstract：:Neoplastic and non-neoplastic lesions may involve the minor salivary glands. Tumors of minor salivary glands are commonly seen in the oral cavity. Malignant tumors are more common than benign minor salivary gland tumors. The most common malignant tumors are adenoid cystic carcinoma and mucoepidermoid carcinoma, and th...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2018.01.008
更新日期：2018-05-01 00:00:00
abstract：:Functional magnetic resonance imaging is able to define noninvasively the location of eloquent cortex responsible for speech, motor, and visual function, and it holds promise for localizing other important functional tissues in the future. Such localization is extremely important to the epileptologist and surgeon plan...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1995-11-01 00:00:00
abstract：:In this article, the authors describe their strategy for intraoperative MR image guidance of tumor resection at low-field (0.2 T) strength. It is their opinion that intraoperative imaging is most useful in assessing the resection of intrinsic, infiltrating brain tumors; boundaries of the tumor cannot be clearly distin...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2001-11-01 00:00:00
abstract：:Vertebral augmentation techniques use image guidance for the percutaneous placement of spinal implants that stabilize a painful osteoporotic or pathologic vertebral compression fracture. The initial implant, acrylic bone cement, was injected through a bone needle into the vertebral body, a procedure referred to as ver...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2010.02.001
更新日期：2010-05-01 00:00:00
abstract：:The epidemic of cardiovascular disease across most of Asia is at a different stage from that in the West; the incidence and prevalence of stroke are increasing steadily, associated with nutritional changes and aging of the population. Epidemiologic data, crucial in combating stroke, have been relatively sparse in Asia...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2005.07.001
更新日期：2005-05-01 00:00:00
abstract：:Biologic connectionism holds as its central tenet that the cognitive, behavioral, and motor functions of the brain are derived from the complex interconnections of simple neural processing units. Much can be learned about the human mind through the study of the brain's connections in normal and diseased states. This a...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2007.07.002
更新日期：2007-11-01 00:00:00
abstract：:Functional MR imaging (fMRI) is being used increasingly to explore the human central auditory system. The considerable background noise produced by echo-planar imaging (EPI) and other fMRI sequences, however, interferes in an unpredictable way with the experimental stimuli. Several approaches exist to overcome this pr...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2001-05-01 00:00:00
abstract：:Neuro-otologists rely on the expertise and judgment of a skilled neuroradiologist to identify radiographic abnormalities in the complicated regional anatomy of the temporal bone and middle and posterior fossa, and more importantly, to alert the surgeon to potential operative pitfalls. This article highlights some of t...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2018.09.008
更新日期：2019-02-01 00:00:00
abstract：:It is difficult to justify maintaining a clinical functional magnetic resonance imaging (fMRI) program based solely on revenue generation. The use of fMRI is, therefore, based mostly in patient care considerations, leading to better outcomes. The high costs of the top-of-the-line equipment, hardware, and software need...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2014.07.007
更新日期：2014-11-01 00:00:00
abstract：:Oral cavity cancer comprises nearly 30% of all malignant tumors of the head and neck. After a definitive diagnosis has been made, imaging is essential for staging the primary tumor by evaluating submucosal spread and invasion of adjacent structures, and to identify nodal or distant metastasis. Oral cavity anatomy is o...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2012.08.004
更新日期：2013-02-01 00:00:00
abstract：:By harnessing the versatility and soft tissue imaging capabilities of MR imaging alongside the unmatched sensitivity and biomolecular flexibility of PET, the potential to provide detailed multiparametric plaque characterization in the carotid arteries is clear. The ability to acquire simultaneous, and dynamic multimod...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2015.09.005
更新日期：2016-02-01 00:00:00
abstract：:The etiology and types of intracranial vasculitis are described, along with a neuroimaging-oriented classification system. Specific entities are discussed in detail. The role of various modalities is defined, as well as a practical approach to diagnosis. ...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1994-11-01 00:00:00
abstract：:Cryotherapy of the brain is an old and well-established technique of functional and resective neurosurgery. With the use of modern imaging techniques such as MR imaging, which is ideally suited for diagnosis, planning, and monitoring of an ablation procedure, cryotherapy can become a modern alternative to other ablati...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：2001-11-01 00:00:00
abstract：:In addition to basic image-guided injections, there are many advanced procedures to address the challenges of spine pain. Patients with debilitating symptoms are offered relief, a shorter recovery period, and fewer potential complications. Pain arises from numerous sites along the spine, presenting as spine pain or ra...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2019.07.005
更新日期：2019-11-01 00:00:00
abstract：:Conventional neuroimaging is still the mainstay in the assessment of the acute, follow-up, and chronic settings of concussion and mild traumatic brain injury (mTBI). Computed tomography (CT) is preferred for the initial assessment of acute mTBI, repeat evaluation in acute mTBI with neurologic deterioration, and cautio...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.nic.2017.09.006
更新日期：2018-02-01 00:00:00
abstract：:This article reviews the essential primary and secondary injuries attributable to traumatic brain injury (TBI) which causes one third of all injury deaths in the United States. Motor vehicle crashes, falls, assaults, guns, sports, and recreational activities are the major causes of TBI. Secondary peak incidences of TB...
journal_title：Neuroimaging clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s1052-5149(02)00009-6
更新日期：2002-05-01 00:00:00
