Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration.

abstract：:The iron-storage protein ferritin was found to be associated with highly purified coated vesicles (CV) from chicken liver. Chicken liver ferritin was morphologically similar to ferritin from horse spleen and could be isolated using a specific anti-ferritin monoclonal antibody. This antibody recognized a 240 X 10(3) Mr...

journal_title：Journal of cell science

authors： Passaniti A,Roth TF

更新日期：1989-02-01 00:00:00

abstract：:We have examined the pattern of expression of four different matrix metalloproteinases (MMPs), collagenase, stromelysin, 92 kD gelatinase, and 72 kD gelatinase, by primary and passaged cultures of rabbit corneal fibroblasts. Primary cultures of this cell type have previously been shown to reproduce the normal tissue r...

journal_title：Journal of cell science

authors： Fini ME,Girard MT

更新日期：1990-10-01 00:00:00

abstract：:Chloroquine resistance in the human malaria parasite, Plasmodium falciparum, arises from decreased accumulation of the drug in the ;digestive vacuole' of the parasite, an acidic compartment in which chloroquine exerts its primary toxic effect. It has been proposed that changes in the pH of the digestive vacuole might ...

journal_title：Journal of cell science

authors： Hayward R,Saliba KJ,Kirk K

更新日期：2006-03-15 00:00:00

abstract：:Myofibroblasts, characterised by high expression of alpha-smooth muscle actin (alpha-SMA), are important and transient cells in normal wound healing but are found in increased number in various pathological conditions of the lung including asthma and pulmonary fibrosis. The mechanisms that regulate the myofibroblast p...

journal_title：Journal of cell science

authors： Scaffidi AK,Moodley YP,Weichselbaum M,Thompson PJ,Knight DA

更新日期：2001-10-01 00:00:00

abstract：:Activator of G-protein signaling 3 (AGS3, also known as GPSM1) regulates the trans-Golgi network. The AGS3 GoLoco motif binds to Gαi and thereby regulates the transport of proteins to the plasma membrane. Compaction of early embryos is based on the accumulation of E-cadherin (Cdh1) at cell-contacted membranes. However...

journal_title：Journal of cell science

authors： Nie ZW,Niu YJ,Zhou W,Zhou DJ,Kim JY,Cui XS

更新日期：2020-12-07 00:00:00

abstract：:Actin-based myosin motors have a pivotal role in intracellular trafficking in eukaryotic cells. The parasitic protozoan organism Leishmania expresses a novel class of myosin, myosin XXI (Myo21), which is preferentially localized at the proximal region of the flagellum. However, its function in this organism remains la...

journal_title：Journal of cell science

authors： Katta SS,Tammana TV,Sahasrabuddhe AA,Bajpai VK,Gupta CM

更新日期：2010-06-15 00:00:00

abstract：:A number of recent studies have highlighted the importance of autophagy and the ubiquitin-proteasome in the pathogenesis of muscle wasting in different types of inherited muscle disorders. Autophagy is crucial for the removal of dysfunctional organelles and protein aggregates, whereas the ubiquitin-proteasome is impor...

journal_title：Journal of cell science

authors： Sandri M,Coletto L,Grumati P,Bonaldo P

更新日期：2013-12-01 00:00:00

abstract：:Inactivation of Simian Virus 40 large T antigen, in cells immortalized with conditional mutants, leads to activation of p53 and apoptosis. We used the mRNA differential display method to identify genes differentially expressed during this process. We found that steady-state levels of mRNA for cytoplasmic actins decrea...

journal_title：Journal of cell science

authors： Guénal I,Risler Y,Mignotte B

更新日期：1997-02-01 00:00:00

abstract：:The identification and characterization of scaffold and targeting proteins of the ERK/MAP kinase pathway is important to understand the function and intracellular organization of this pathway. The F-actin binding protein leukocyte-specific protein 1 (LSP1) binds to PKCbetaI and expression of B-LSP1, an LSP1 truncate c...

journal_title：Journal of cell science

authors： Harrison RE,Sikorski BA,Jongstra J

更新日期：2004-04-15 00:00:00

abstract：:During angiogenesis, endothelial cells must coordinate matrix proteolysis with migration. Here, we tested whether the focal adhesion scaffold protein Hic-5 (also known as TGFB1I1) regulated endothelial sprouting in three dimensions. Hic-5 silencing reduced endothelial sprouting and lumen formation, and sprouting defec...

journal_title：Journal of cell science

authors： Dave JM,Abbey CA,Duran CL,Seo H,Johnson GA,Bayless KJ

更新日期：2016-02-15 00:00:00

abstract：:In the central nervous system, oligodendrocytes synthesize vast amounts of myelin, a multilamellar membrane wrapped around axons that dramatically enhances nerve transmission. A complex apparatus appears to coordinate trafficking of proteins and lipids during myelin synthesis, but the molecular interactions involved a...

journal_title：Journal of cell science

authors： Anitei M,Ifrim M,Ewart MA,Cowan AE,Carson JH,Bansal R,Pfeiffer SE

更新日期：2006-03-01 00:00:00

abstract：:Compartmentalization of membrane transport and signaling processes is of pivotal importance to eukaryotic cell function. While plasma membrane compartmentalization and dynamics are well known to depend on the scaffolding function of septin GTPases, the roles of septins at intracellular membranes have remained largely ...

journal_title：Journal of cell science

authors： Song K,Gras C,Capin G,Gimber N,Lehmann M,Mohd S,Puchkov D,Rödiger M,Wilhelmi I,Daumke O,Schmoranzer J,Schürmann A,Krauss M

更新日期：2019-02-01 00:00:00

abstract：:Nodal signaling induces the formation of the endoderm and mesoderm during gastrulation. Nodal expression persists until the definitive endoderm progenitor has completely formed, and disappears thereafter. A tightly regulated Nodal expression system is essential for the differentiation of embryonic stem (ES) cells into...

journal_title：Journal of cell science

authors： Takenaga M,Fukumoto M,Hori Y

更新日期：2007-06-15 00:00:00

abstract：:Endocytosis and recycling of membrane proteins are key processes for nutrient uptake, receptor signaling and synaptic transmission. Different steps in these fission and fusion cycles have been proposed to be regulated by physiological changes in plasma membrane (PM) phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)...

journal_title：Journal of cell science

authors： Abe N,Inoue T,Galvez T,Klein L,Meyer T

更新日期：2008-05-01 00:00:00

abstract：:Intermediate filaments (IFs) undergo specific rearrangements in cells, some aspects of which can be induced experimentally. Centripetal aggregation of the IF network, for example, can be produced by a variety of perturbations. However, the source of motive force is clear for neither in vivo nor experimentally generate...

journal_title：Journal of cell science

authors： Tint IS,Hollenbeck PJ,Verkhovsky AB,Surgucheva IG,Bershadsky AD

更新日期：1991-03-01 00:00:00

abstract：:Increased deposition of collagen in extracellular matrix (ECM) leads to increased tissue stiffness and occurs in breast tumors. When present, this increases tumor invasion and metastasis. Precisely how this deposition is regulated and maintained in tumors is unclear. Much has been learnt about mechanical signal transd...

journal_title：Journal of cell science

authors： Zhang K,Grither WR,Van Hove S,Biswas H,Ponik SM,Eliceiri KW,Keely PJ,Longmore GD

更新日期：2016-05-15 00:00:00

abstract：:Talin binds to β-integrin tails to activate integrins, regulating cell migration, invasion and metastasis. There are two talin genes, TLN1 and TLN2, encoding talin1 and talin2, respectively. Talin1 regulates focal adhesion dynamics, cell migration and invasion, whereas the biological function of talin2 is not clear an...

journal_title：Journal of cell science

authors： Qi L,Jafari N,Li X,Chen Z,Li L,Hytönen VP,Goult BT,Zhan CG,Huang C

更新日期：2016-10-01 00:00:00

abstract：:Low-density lipoprotein (LDL) deposition, aggregation and retention in the endothelial sub-intima are critical initiating events during atherosclerosis. Macrophages digest aggregated LDL (agLDL) through a process called exophagy. High-density lipoprotein (HDL) plays an atheroprotective role, but studies attempting to ...

journal_title：Journal of cell science

authors： Singh RK,Lund FW,Haka AS,Maxfield FR

更新日期：2019-12-02 00:00:00

abstract：:Alpha4 integrins are used by leukocytes and neural crest derivatives for adhesion and migration during embryogenesis, immune responses and tumour invasion. The pro-migratory activity of alpha4 integrin is mediated in part through the direct binding of the cytoplasmic domain to paxillin. Here, using intermolecular FRET...

journal_title：Journal of cell science

authors： Deakin NO,Bass MD,Warwood S,Schoelermann J,Mostafavi-Pour Z,Knight D,Ballestrem C,Humphries MJ

更新日期：2009-05-15 00:00:00

abstract：:Reactive oxygen species (ROS) produced by the NADPH oxidase (NOX) complex play important physiological and pathological roles in neurotransmission and neurodegeneration, respectively. However, the contribution of ROS to the molecular mechanisms involved in neuronal polarity and axon elongation is not well understood. ...

journal_title：Journal of cell science

authors： Wilson C,Núñez MT,González-Billault C

更新日期：2015-08-15 00:00:00

abstract：:Dishevelled-3 (Dvl3) is a multivalent scaffold protein that is essential to Wnt signaling during development. Although Dvl-based punctae have been visualized by fluorescence microscopy; the physical nature and dynamic character of the such complexes are enigmatic. We use steric-exclusion chromatography, affinity pull-...

journal_title：Journal of cell science

authors： Yokoyama N,Golebiewska U,Wang HY,Malbon CC

更新日期：2010-11-01 00:00:00

abstract：:Dystrophic forms of epidermolysis bullosa (DEB) are associated with mutations in the type VII collagen gene (Col7a1) which encodes the major component of anchoring fibrils. To develop a DEB animal model, type VII collagen deficient mice were generated by targeted homologous recombination. The targeting vector replaced...

journal_title：Journal of cell science

authors： Heinonen S,Männikkö M,Klement JF,Whitaker-Menezes D,Murphy GF,Uitto J

更新日期：1999-11-01 00:00:00

abstract：:The cell types expressing cot proto-oncogene mRNA were identified by in situ hybridization (ISH) histochemistry. Among a variety of adult mouse tissues examined, four types of glandular cells expressing cot gene were identified: (1) granular duct cells in the submandibular and sublingual glands; (2) serous cells in th...

journal_title：Journal of cell science

authors： Ohara R,Hirota S,Onoue H,Nomura S,Kitamura Y,Toyoshima K

更新日期：1995-01-01 00:00:00

abstract：:We have used cell-surface-specific labelling techniques and two-dimensional gel electrophoresis to identify proteins on embryonic chick neural retina cells and to determine the effects of Ca2+ on their accessibility to labelling and tryptic removal. A number of proteins on these cells are, in the presence of Ca2+, rel...

journal_title：Journal of cell science

authors： Cook JH,Lilien J

更新日期：1982-06-01 00:00:00

abstract：:In 1993, a Commentary in this journal described how a simple mechanical model of cell structure based on tensegrity architecture can help to explain how cell shape, movement and cytoskeletal mechanics are controlled, as well as how cells sense and respond to mechanical forces (J. Cell Sci. 104, 613-627). The cellular ...

journal_title：Journal of cell science

authors： Ingber DE

更新日期：2003-04-01 00:00:00

abstract：:Calnexin and calreticulin are related proteins that comprise an ER chaperone system that ensures the proper folding and quality control of newly synthesized glycoproteins. The specificity for glycoproteins is conferred by a lectin site that recognizes an early oligosaccharide processing intermediate on the folding gly...

journal_title：Journal of cell science

authors： Williams DB

更新日期：2006-02-15 00:00:00

abstract：:An electron microscopic investigation of the events associated with meiosis in Lilium has revealed a number of changes in both the organellar population and the other cytoplasmic components. Ribosome numbers decrease significantly in early prophase and are later replenished in the tetrads, a process most likely involv...

journal_title：Journal of cell science

authors： Bird J,Porter EK,Dickinson HG

更新日期：1983-01-01 00:00:00

abstract：:Protein kinase CK2, a vital, pleiotropic and highly conserved serine/threonine phosphotransferase is involved in transcription-directed signaling, gene control and cell cycle regulation and is suspected to play a role in global processes. Searching for these global roles, we analyzed the involvement of CK2 in gene exp...

journal_title：Journal of cell science

authors： Barz T,Ackermann K,Dubois G,Eils R,Pyerin W

更新日期：2003-04-15 00:00:00

abstract：:FAS associated factor 1 (FAF1) has been described as an unusual protein that binds to the intracellular portion of the apoptosis signal transducing receptor FAS/Apo-1 and potentiates apoptosis in L-cells. By means of mRNA differential display we have identified the avian homologue (qFAF) as a fibroblast growth factor-...

journal_title：Journal of cell science

authors： Fröhlich T,Risau W,Flamme I

更新日期：1998-08-01 00:00:00

abstract：:Nemaline myopathy (NM) is a congenital myopathy with an estimated incidence of 150,000 live births. It is caused by mutations in thin filament components, including nebulin, which accounts for about 50% of the cases. The identification of NM cases with nonsense mutations resulting in loss of the extreme C-terminal SH3...

journal_title：Journal of cell science

authors： Yamamoto DL,Vitiello C,Zhang J,Gokhin DS,Castaldi A,Coulis G,Piaser F,Filomena MC,Eggenhuizen PJ,Kunderfranco P,Camerini S,Takano K,Endo T,Crescenzi M,Luther PK,Lieber RL,Chen J,Bang ML

更新日期：2013-12-01 00:00:00