Abstract:
OBJECTIVES:Electroencephalographic burst activity characteristic of burst-suppression pattern (BSP) in sedated patients and of burst-interburst pattern (BIP) in the quiet sleep of healthy neonates have similar linear and non-linear signal properties. Strong interrelations between a slow frequency component and rhythmic, spindle-like activities with higher frequencies have been identified in previous studies. Time-varying characteristics of BSP and BIP prevent a definite patternrelated analysis. A continuous estimation of the bispectrum is essential to analyze these patterns. Parametric bispectral approaches provide this opportunity. METHODS:The adaptation of an AR model leads to a parametric bispectrum by using the transfer function of the estimated AR filter. Time-variant parametric bispectral approaches require an estimation of AR parameters which consider higher order moments to preserve phase information. Accordingly, a time-variant parametric estimation of the bispectrum was introduced. Data driven simulations were performed to provide optimal parameters. BSP (12 patients) and BIP (6 neonates) were analyzed using this novel approach. RESULTS:Significant differences in the time course of burst pattern during BSP and burst-like pattern before the onset of BSP could be shown. A rhythmic quadratic phase coupling (period 10 sec) was identified during BIP in all neonates. CONCLUSION:Quadratic phase couplings during BSP increases in the time course depending on depth of sedation. The visually detected burst activity in BIP is only the temporarily observable EEG correlate of a hidden neural process. Time-variant bispectral approaches offer the possibility of a better characterization of underlying neural processes leading to improved diagnostic tools used in clinical routine.
journal_name
Methods Inf Medjournal_title
Methods of information in medicineauthors
Schwab K,Eiselt M,Schelenz C,Witte Hkeywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
374-83issue
3eissn
0026-1270issn
2511-705Xpii
05030374journal_volume
44pub_type
杂志文章abstract:OBJECTIVES:The filtered backprojection is not able to cope with metal-induced inconsistencies in the Radon space which leads to artifacts in reconstructed CT images. A new algorithm is presented that reduces the drawbacks of existing artifact reduction strategies. METHODS:Inconsistent projection data are bridged by di...
journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:10.1160/ME9041
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:Recent results published by Coste et al. in discriminant analysis with ordinal responses showed the superiority of optimal discriminating analysis for ordinal responses (ODAO) both in terms of classification and simplicity of implementation compared to classic methods (Fisher's discrimination, logistic regres...
journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::To examine inter-observer variation in the monitoring of patients with chronic disease, four nephrologists independently assessed 62 patients on maintenance hemodialysis. Deviation from normal was determined for adequacy of dialysis, protein intake, and metabolic state. The kappa-index, which allows to adjust for chan...
journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVES:Our objective is to investigate diabetes-related alteration of glucose control in diurnal fluctuations in normal daily life by detrended fluctuation analysis (DFA). METHODS:The fluctuations of glucose of 12 non-diabetic subjects and 15 diabetic patients were measured using a continuous glucose monitoring sy...
journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To evaluate split selection instability in six survival tree algorithms and its relationship with predictive error by means of a bootstrap study. METHODS:We study the following algorithms: logrank statistic with multivariate p-value adjustment without pruning (LR), Kaplan-Meier distance of survival curves (...
journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:The main objective of this study is to learn more on the image use and search requirements of radiologists. These requirements will then be taken into account to develop a new search system for images and associated meta data search in the Khresmoi project. METHODS:Observations of the radiology workflow, ca...
journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:10.3414/ME11-02-0025
更新日期:2012-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:10.3414/ME15-15-0009
更新日期:2016-08-05 00:00:00
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journal_title:Methods of information in medicine
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:10.3414/ME11-02-0049
更新日期:2013-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:10.3414/ME9302
更新日期:2010-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:10.3414/ME13-01-0137
更新日期:2014-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:10.3414/ME13-02-0032
更新日期:2014-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:10.3414/ME0519
更新日期:2011-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:The aim of this project is to develop a catalogue of competency-based learning objectives "Medical Informatics" for undergraduate medical education (abbreviated NKLM-MI in German). METHODS:The development followed a multi-level annotation and consensus process. For each learning objective a reason why a phy...
journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:10.3414/ME13-04-0001
更新日期:2013-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Methods of information in medicine
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00