Abstract：
OBJECTIVE:Recent results published by Coste et al. in discriminant analysis with ordinal responses showed the superiority of optimal discriminating analysis for ordinal responses (ODAO) both in terms of classification and simplicity of implementation compared to classic methods (Fisher's discrimination, logistic regression) applied to medical data (prognostics of burns) and to simulated data. Nevertheless, the solutions obtained by ODAO may be sensitive to re-sampling (i.e the estimated coefficients by ODAO may show excessive sensitivity to the training sample). This study proposes some solutions to control the fluctuations of sampling and to ensure model stability. METHODS:We used intensive computational methods and bootstrapping, at the outset of model building in order to reduce the sampling variability of estimated coefficients. Thus, the estimation of the coefficients was not based on the minimization of a classification criterion of the training sample, but on the minimization of an aggregate criterion of bootstrapped replications of a classification criterion. Five aggregate criteria were studied. RESULTS:The improvement in terms of robustness appeared in 30% of the test cases with moderate training sample size and 55% of those with small training sample size. CONCLUSION:Simulated test cases showed that bootstrapping can help construct more robust models in difficult classification situations and small training samples which are particularly frequent.
journal_name
Methods Inf Medjournal_title
Methods of information in medicineauthors
Le Teuff G,Quantin C,Venot A,Walter E,Coste Jkeywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
704-11issue
5eissn
0026-1270issn
2511-705Xpii
05050704journal_volume
44pub_type
杂志文章abstract：:This paper presents a tutorial introduction to the handling of uncertainty and decision-making in medical reasoning systems. It focuses on the central role of uncertainty in all of medicine and identifies the major themes that arise in research papers. It then reviews simple Bayesian formulations of the problem and pu...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：:A few years ago, a new method of survival analysis, denoted period analysis, has been developed to derive more up-to-date estimates of long-term survival rates of cancer patients, but this method has rarely been applied so far. Using empirical examples from the Saarland Cancer Registry, we illustrate how seriously tra...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:The International Classification of Functioning, Disability and Health (ICF) has been available as a means of coding life functions but the coding process is cumbersome due to the large number of ICF codes. In the current study, we developed ICF code selection tools to support the coding of activity and part...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME10-01-0062
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to explore suitable spatial filters for inverse estimation of cortical potentials from the scalp electroencephalogram. The effect of incorporating noise covariance into inverse procedures was examined by computer simulations and tested in human experiment. METHODS:The paramet...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Validation of expert system knowledge bases has proved to be difficult. This paper presents a description of a system called ScriptGen that generates test data for validating the knowledge base of the ONCOCIN cancer therapy planning system. Because of the size and complexity of the ONCOCIN knowledge base, we require t...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVES:As a preliminary for the design of Computer-Based Patient Records, the aim of this paper is to build an understanding of the roles physical artifacts like paper-based patient records play in supporting cognition and collaboration in the health-care settings. METHOD:A small ethnographically-informed study wa...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:We present an algorithm for reconstructing the bifurcation structure of a dynamical system from time series. The method consists in finding a parameterized predictor function whose bifurcation structure is similar to that of the given system. Nonlinear autoregressive (NAR) models with polynomial terms are employed as ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVES:To assess the impact of a CPOE system on medication-related communication of nurses and physicians. METHODS:In six internal medicine wards of an academic medical center, two questionnaires were used to evaluate nurses' attitudes toward the impact of a paper-based medication system and then a CPOE system on ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME0572
更新日期：2009-01-01 00:00:00
abstract：:Three ways are proposed to help the occupational physician in constructing a worker's job history or Curriculum Laboris (CL) with a PC. The quality and, therefore, the usefulness of any job history is greatly conditioned by the method and quality of data collection. The Curriculum Laboris method explained in a previou...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to investigate the effects of hybrid environments (i.e. where part of the patient record is paper-based and part of it is electronic) upon aspects of novice nurse information seeking (i.e. amount of information accessed, choice of key information sources, type of information and ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME9222
更新日期：2009-01-01 00:00:00
abstract：:Artificial neural networks (ANNs) are compared to standard statistical methods for outcome prediction in biomedical problems. A general method for using genetic algorithms to "evolve" ANN architecture (EANN) is presented. Accuracy of logistic regression, a fully interconnected ANN, and an EANN for predicting depressio...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVES:To discuss application areas of information technology in medicine and health care on the occasion of the opening of the Private Universität für Medizinische Informatik und Technik Tirol/University for Health Informatics and Technology Tyrol (UMIT) at Innsbruck, Tyrol, Austria. RESULTS AND CONCLUSIONS:Impor...
journal_title：Methods of information in medicine
pub_type：
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVE:To intensify the collaboration between WHO, the World Health Organization, and IMIA, the International Medical Informatics Association. METHODS:Identifying key areas of collaboration and publishing a joint communiqué during Medinfo 2007 in Brisbane, Australia. RESULTS AND CONCLUSIONS:WHO and IMIA have ident...
journal_title：Methods of information in medicine
pub_type： 社论
doi：10.1160/me5006
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVES:Combination of multiple testing and modeling techniques in dose-response studies. Use of hypotheses tests to assess the significance of the dose-response signal associated with a given candidate dose-response model. Estimation of target dose(s) following the previous model selection step. Illustration of the...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Surgical fluid replacement is a critical issue in medicine as the fluid volume excess or deficit can both complicate the patient's condition. Currently, the administration of fluid volume is carried out primarily based on the experience and expertise of the anaesthetist as there is no analytical method available to es...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：:A rough-sets approach was applied to a data set consisting of animal study results and other compound characteristics to generate local and global (certain/possible) sets of rules for prediction of developmental toxicity in human subjects. A modified version of the rough-sets approach is proposed to allow the construc...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：UNLABELLED:The HL7 Clinical Document Architecture (CDA) is an important XML-based standard for the representation of clinical documents. OBJECTIVES:The use of Markup Languages could satisfy the demands of involved healthcare staff as well as the needs of patients, to receive an overview of the patient's treatment duri...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Until recently, genotype studies were limited to the investigation of single SNP effects due to the computational burden incurred when studying pairwise interactions of SNPs. However, some genetic effects as simple as coloring (in plants and animals) cannot be ascribed to a single locus but only understood w...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME11-02-0049
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:This article is part of the Focus Theme of METHODS of Information in Medicine on "Managing Interoperability and Complexity in Health Systems". BACKGROUND:Data sharing and integration between the clinical research data management system and the electronic health record system remains a challenging issue. T...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-02-0019
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:To identify factors associated with hospital length of stay (LOS) and to model variations in LOS within Diagnosis Related Groups (DRGs). METHODS:A proportional hazards frailty modelling approach is proposed that accounts for patient transfers and the inherent correlation of patients clustered within hospita...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVES:The huge amount of released medical apps prevents medical app users from believing that medical scientific societies and other accreditation bodies as well, have the resources and the power for assigning to any medical app a quality score. By the time being, any medical app user has to take the risks related...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-01-0093
更新日期：2014-01-01 00:00:00
abstract：:Natural language understanding systems have to exploit various kinds of knowledge in order to represent the meaning behind texts. Getting this knowledge in place is often such a huge enterprise that it is tempting to look for systems that can discover such knowledge automatically. We describe how the distinction betwe...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：OBJECTIVE:Joint data analysis is a key requirement in medical research networks. Data are available in heterogeneous formats at each network partner and their harmonization is often rather complex. The objective of our paper is to provide a generic approach for the harmonization process in research networks. We applied...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME14-02-0030
更新日期：2015-01-01 00:00:00
abstract：:The graduates and students of the School of Health Information Science (HIS) at the University of Victoria (UVic) have pioneered the Canadian sphere in health informatics since 1982. After six years of growth this co-operative education program has matured and establishment of a research base and graduate school has b...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：:To examine inter-observer variation in the monitoring of patients with chronic disease, four nephrologists independently assessed 62 patients on maintenance hemodialysis. Deviation from normal was determined for adequacy of dialysis, protein intake, and metabolic state. The kappa-index, which allows to adjust for chan...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：OBJECTIVES:Personal digital assistants (PDAs) are in widespread use by resident physicians in many countries, reaching as high as 95% in some reports. Uses are varied and include clinical decision support and support of evidence-based practice. Utilization by resident doctors in Japan has not been characterized. This s...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME0607
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:The main objective of this study is to learn more on the image use and search requirements of radiologists. These requirements will then be taken into account to develop a new search system for images and associated meta data search in the Khresmoi project. METHODS:Observations of the radiology workflow, ca...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME11-02-0025
更新日期：2012-01-01 00:00:00
abstract：:A compartmental model for the simulation of in-vivo insulin-like growth factor one (IGF-I) kinetics and metabolism is presented. The model is based on the concept that IGF binding proteins (IGFBPs) act as a reservoir for IGF-I in plasma, thereby restricting its access to the extravascular space. The model is divided i...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:The use of computers in the field of medical education is common. Our purpose is to present a Computer-Assisted Instruction system which has been developed over ten years at the University of Compiègne and the University of Rennes Medical School. This system can be used to help the student to solve clinical cases by a...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:Based on personal experiences, observations are offered on health information in developing countries, ways in which information systems can be strengthened, and opportunities for health-information science graduates. Although data collection consumes a significant portion of the health worker's day, information syste...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
