Molecular pathology and pathogenesis of inclusion-body myositis.

Abstract:

:We summarize the molecular phenotype, diagnostic criteria, and the newest advances related to seeking the pathogenic mechanism(s) of sporadic inclusion-body myositis (s-IBM), a muscle disease usually of persons over age 50. On the basis of our research, several processes seem to be important in relation to the still-speculative pathogenesis: 1) increased transcription and accumulation of amyloid-beta precursor protein (AbetaPP), and accumulation of its proteolytic fragment Abeta; 2) abnormal accumulation of cholesterol, caveolin-1, and apolipoprotein E; 3) oxidative stress; 4) accumulations of intramuscle fiber multiprotein aggregates; and 5) evidence that unfolded/misfolded proteins participate in s-IBM pathogenesis. Our basic hypothesis is that overexpression of AbetaPP within the aging muscle fibers is an early upstream event causing a subsequent pathogenic cascade.

journal_name

Microsc Res Tech

authors

Askanas V,Engel WK

doi

10.1002/jemt.20186

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

114-20

issue

3-4

eissn

1059-910X

issn

1097-0029

journal_volume

67

pub_type

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