Abstract:
:We summarize the molecular phenotype, diagnostic criteria, and the newest advances related to seeking the pathogenic mechanism(s) of sporadic inclusion-body myositis (s-IBM), a muscle disease usually of persons over age 50. On the basis of our research, several processes seem to be important in relation to the still-speculative pathogenesis: 1) increased transcription and accumulation of amyloid-beta precursor protein (AbetaPP), and accumulation of its proteolytic fragment Abeta; 2) abnormal accumulation of cholesterol, caveolin-1, and apolipoprotein E; 3) oxidative stress; 4) accumulations of intramuscle fiber multiprotein aggregates; and 5) evidence that unfolded/misfolded proteins participate in s-IBM pathogenesis. Our basic hypothesis is that overexpression of AbetaPP within the aging muscle fibers is an early upstream event causing a subsequent pathogenic cascade.
journal_name
Microsc Res Techjournal_title
Microscopy research and techniqueauthors
Askanas V,Engel WKdoi
10.1002/jemt.20186keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
114-20issue
3-4eissn
1059-910Xissn
1097-0029journal_volume
67pub_type
杂志文章,评审abstract::Tumor necrosis factor (TNF) exists in two bioactive forms, the membrane integrated form and the proteolytically derived soluble cytokine. Both forms of TNF are involved in a variety of different physiological and pathophysiological situations. Here we analyzed different human and mouse TNF-specific reagents for their ...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/1097-0029(20000801)50:3<243::AID-JEMT8>3.0
更新日期:2000-08-01 00:00:00
abstract::Sensory mechanisms in teeth are not well understood and may involve pulpal-neural interactions. Tooth cells that proliferate in vitro have polyclonal immunoreactivity (IR) for glial fibrillary acidic protein (GFAP), growth-associated protein (GAP-43), and vimentin, plus glial-like ion channels. Here, we analyzed GFAP-...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20130
更新日期:2004-12-01 00:00:00
abstract::We present a semiautomated software solution to the problem of extending the lateral field of view of a classical microscope. The initial requirements are a set of overlapping images, along with their user-provided coarse mosaic. Our solution then refines this initial mosaic in a fully automatic fashion. We rely on a ...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20393
更新日期:2007-02-01 00:00:00
abstract::In spite of accumulating evidence for a modulation of sympathetic neurotransmission by endogenously produced nitric oxide (NO), it remains unclear in which parts of the vascular system and at what level this interaction takes place. The aim of the present study was to investigate the distribution of endothelial and ne...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.1070290214
更新日期:1994-10-01 00:00:00
abstract::Multifunctional involvement of actin microfilaments during viral infection has been documented in many studies. The molecular mechanism underlying this important host-virus interaction, however, remains poorly understood. We have investigated the role of actin microfilaments in the life cycle of human parainfluenza vi...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0029(19991015)47:2<114::AID-JEM
更新日期:1999-10-15 00:00:00
abstract::The presence of hard jaws (trophi), with species-specific shape and size, is a taxonomic feature of Rotifera, a group of microscopic metazoans. Since trophi are used to discriminate among species, it is important to know whether these structures change in taxonomically important ways during postembryonic development. ...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20319
更新日期:2006-04-01 00:00:00
abstract::The Dominican Republic (DR) has experienced tremendous increase in the number of cases of dengue virus (DENV) reported in the past few years. There are four serotypes of DENV (1-4), and each can cause classic dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS). DENV-1-4 are currently circ...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20225
更新日期:2005-11-01 00:00:00
abstract::Automated detection and classification of gastric infections (i.e., ulcer, polyp, esophagitis, and bleeding) through wireless capsule endoscopy (WCE) is still a key challenge. Doctors can identify these endoscopic diseases by using the computer-aided diagnostic (CAD) systems. In this article, a new fully automated sys...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23447
更新日期:2020-05-01 00:00:00
abstract::We discuss the use of fluorescence correlation spectroscopy for the measurement of relatively slow rotations of large macromolecules in solution or attached to other macromolecular structures. We present simulations and experimental results to illustrate the range of rotational correlation times and diffusion times th...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20121
更新日期:2004-11-01 00:00:00
abstract::A new and improved technique for microvascular corrosion casting was developed and verified by examination of corrosion casts of 90 bovine limbs. The described technique renders a complete filling of the vasculature of the claw even in regions that hitherto proved to be difficult regarding completeness of filling such...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0029(19990501)45:3<184::AID-JEM
更新日期:1999-05-01 00:00:00
abstract::In recent years, the zebrafish Danio rerio has emerged as a powerful model organism for the study of vertebrate embryogenesis. Zebrafish, like other vertebrates, possess pigment cells that arise from two distinct embryonic sources: those of the dermis and epidermis originate from the neural crest, while those that com...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/jemt.10161
更新日期:2002-09-15 00:00:00
abstract::There is increasing evidence for the important role played by regulatory peptides in the physiology of the normal and neoplastic prostate. Adrenomedullin (AM) and pro-adrenomedullin N-terminal 20 peptide (PAMP) are recently discovered regulatory peptides widely expressed in the normal prostate and in prostate carcinom...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/jemt.10056
更新日期:2002-04-15 00:00:00
abstract::Nonlinear microscopy techniques are being increasingly used to perform in vivo studies in dermatology. These methods enable us to investigate the morphology and monitor the physiological process in the skin by the use of femtosecond lasers operating in the red, near-infrared spectral range (680-1,300 nm). In this work...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.22545
更新日期:2015-09-01 00:00:00
abstract::Locusts are attractive model preparations for cellular investigations of neurodevelopment. In this study, we investigate the immunocytochemical localization of histamine in the developing ventral nerve cord of two locust species, Schistocerca gregaria and Locusta migratoria. Histamine is the fast neurotransmitter of p...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.20980
更新日期:2011-10-01 00:00:00
abstract::Various labial and lingual orthodontic appliances with aesthetic materials have been developed due to an increased demand in aesthetic orthodontic treatment. However, there are few reports regarding the morphology of lingual orthodontic appliances. Therefore, this study evaluates the roughness of slot surfaces of vari...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.22775
更新日期:2016-12-01 00:00:00
abstract::Most of the molecular and experimental studies on the floor plate (FP) have been performed on the FP region extending along the spinal cord. However, little is known about the hindbrain FP. The FP undergoes regional and temporal changes throughout development, but information with respect to the ultrastructural correl...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/1097-0029(20010301)52:5<615::AID-JEMT1045>
更新日期:2001-03-01 00:00:00
abstract::This study was conducted to provide comprehensive information on the anatomical and histological features of the upper (UL) and lower (LL) lips of Rahmani sheep by gross examination, morphometric analysis in addition to Light and scanning electron microscope (SEM). Samples from normal healthy adult male sheep heads we...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23660
更新日期:2020-12-01 00:00:00
abstract::The catecholaminergic cell groups in the human brain, denominated from A1 to A17, display some striking anatomical differences with those described in the rodent. These differences are essentially observed in the extent of the dopaminergic neurons and especially their axonal fields in the telencephalon. Immunocytochem...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0029(19990701)46:1<24::AID-JEMT
更新日期:1999-07-01 00:00:00
abstract::The research was performed to investigate pollen morphology of endangered species of Capparidaceae in subtropical regions of Pakistan. The distinguishing characters were investigated by using light microscope and scanning electron microscope. Palynological study is comprised of pollen shape, pollen type, exine sculptu...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23292
更新日期:2019-09-01 00:00:00
abstract::The morphology and ultrastructure of the rectum in Poecilimon cervus Karabağ, 1950 (Orthoptera, Tettigoniidae) were analyzed by light microscope, scanning (SEM) and transmission electron microscopes (TEM). The rectum is the final part of the digestive tract that plays an important role in water reabsorption in insects...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.22787
更新日期:2017-02-01 00:00:00
abstract::Morphological studies of the microcirculatory system in the thymus were reviewed in regards to methodology and structural organization of blood and lymphatic vessels. The blood capillaries and postcapillary venules (PCVs) in the thymus are characterized by a double-walled structure. These vessels are surrounded more o...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0029(19970801)38:3<287::AID-JEM
更新日期:1997-08-01 00:00:00
abstract::Complicated stages of diabetes are the major cause of Diabetic Retinopathy (DR) and no symptoms appear at the initial stage of DR. At the early stage diagnosis of DR, screening and treatment may reduce vision harm. In this work, an automated technique is applied for detection and classification of DR. A local contrast...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23063
更新日期:2018-09-01 00:00:00
abstract::The perivitelline space of mammalian oocytes changes in size and composition during preimplantation development. Often overlooked in the past, this space contains a hyaluronan-rich extracellular matrix prior to fertilization and a cortical granule envelope following release of the cortical granules at fertilization. T...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.10348
更新日期:2003-07-01 00:00:00
abstract::In addition to pesticidal activity, the capacity of natural compounds to inhibit the reproduction of parasites emerge as an important alternative tick control method. In this context, Satureja spp. stand out due to their recognized pesticidal properties. Among parasites of veterinary importance, the cattle tick, Rhipi...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23693
更新日期:2021-01-06 00:00:00
abstract::GABA is a likely feedback transmitter from H1 horizontal cells to cone photoreceptors in fish retinas. Spinules arise from H1 cell dendrites in light-adapted retinas, are correlated with responses attributed to feedback, and have been proposed to be the GABA release sites. We used mAb 62-3G1, an antibody against the b...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0029(19970101)36:1<43::AID-JEMT
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:To examine different types of restorative materials used in children as well as primary and permanent teeth enamel when affected by erosive foods. MATERIALS AND METHOD:Buttermilk, fruit yoghurt, Coca-cola, fruit juice, Filtek Z-250, Dyract Extra, Fuji II LC, and Fuji IX and tooth enamel were used. Measureme...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.22315
更新日期:2014-01-01 00:00:00
abstract::In the current investigation, 16 samples of six species of the genus Polygonatum were collected from different geographical regions in China. Leaf micromorphological traits were studied in detail using scanning electron microscopy. About five-leaf samples were used for each species collected from different geographica...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23529
更新日期:2020-11-01 00:00:00
abstract::To investigate intrinsic physicochemical properties and interactions of three different calcium hydroxide-based medications via means of different analytical methods. Two-commercial premixed medications: TempCanal(TCmx) and ProCalR(PCmx) and powder-form ProCal(PCpw) with glycerin were used. Vibrational modes were anal...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.23600
更新日期:2020-09-21 00:00:00
abstract::During the emergence of multicellular organisms, molecular mechanisms evolved to allow maintenance of anatomical integrity and self-recognition. We propose that carbohydrates from proteoglycans, as the most peripheral cell surface, and matrix molecules might have provided these key adhesion and recognition functions. ...
journal_title:Microscopy research and technique
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0029(19990215)44:4<304::AID-JEM
更新日期:1999-02-15 00:00:00
abstract::A new method to study the developing heart was developed. Using this "section directed" cryosectioning method, appropriate fixed embryos can be trimmed optimally to obtain sectional planes that, if necessary, can be matched with histologically treated sections. As a result, the morphological information obtained with ...
journal_title:Microscopy research and technique
pub_type: 杂志文章
doi:10.1002/jemt.1070300606
更新日期:1995-04-15 00:00:00