Abstract：
OBJECTIVE:Interleukin-6 (IL-6) is a specific marker of early onset infections in the newborns. In recent years it has been suggested that in regulations of IL-6 activity could play a role the genetic polymorphism (-174G/C) in the promoter region of the gene coding for IL-6. The aim of our study was to analyse the frequency of -174G/C polymorphism of interleukin-6 gene as a genomic marker for individuals at an increased risk of early onset neonatal infection as result of intra-amniotic infection (IAI). MATERIAL AND METHOD:A prospective study was conducted in 62 newborns treated in University Hospital tertiary neonatal intensive care unit. Intrauterine infection was diagnosed in 21 children and 41 neonates comprised control group. In the both groups we have analysed -174G/C polymorphism in the gene coding IL-6 using PCR/RFLP (polymerase chain reaction/restriction fragment length polymorphism) assays. RESULTS:We have observed the overrepresentation of homozygous genotypes -174C/C in the investigated group (9.5% vs. 7.3% in the controls). The frequency of heterozygous genotypes -174G/C was higher in investigated group 61.9% than in controls 56.1%. Homozygous wild type genotypes for -174G/G were detected in 28.6% and 36.6% in investigated group and controls, respectively. These proportions were consistent with the Hardy-Weinberg equilibrium. Analysing allelic frequency we have noticed overrepresentation of -174C alleles in the investigated group (40.5% vs. 35.4% in the controls, O.R. = 1.24, n.s.). CONCLUSION:The presence of the C allele in the -174 position in the gene coding for IL-6 could play a role in the pathology of neonatal infection following IAI in the mother and probably is connected with decreased of immunological reaction.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Wojsyk-Banaszak I,Seremak-Mrozikiewicz A,Szczapa J,Drews K,Zandecka-Dziubak J,Mrozikiewicz PMkeywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
127-34issue
2eissn
0017-0011issn
2543-6767journal_volume
76pub_type
杂志文章abstract：OBJECTIVES:To evaluate data regarding neonatal mortality and short term morbidity among iatrogenic late preterm (ILP) and spontaneous late preterm (SLP) twin births, and to estimate whether medical interventions - induction of labor in this particular context, are associated with better or poorer outcomes. MATERIAL AN...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1600
更新日期：2013-06-01 00:00:00
abstract：THE AIM OF STUDY:Estimation of Polish population standards of the concentrations of pregnancy-associated plasma protein--A (PAPP-A) and free beta--human chorionic gonadotropin (beta-HCG) in the maternal blood between 10.0 and 13.6 week of pregnancy and comparison of the biochemistry own normal ranges and literature rep...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：:The authors evaluated the influence of NAD, NADP, G-6-P and G-6-PDH on the synthesis of steroid hormones in the interstitial gland of the rat. The animals were killed by decapitation, and sections of the nucleus weighing altogether 20 mg were incubated with NAD (0.4 mM), NADP (0.4 mM), G-6-P (3.5 mM) and G-6-PDH (2 j....
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：OBJECTIVES:Preterm premature rupture of membranes (PPROM) complicates about 5% of pregnancies. Ureaplasma species is the most common pathogen found in the amniotic fluid in pregnancieneonatal outcome. The aim of the following study was to evaluate the impact of colonization with the Ureaplasma spp. on pregnant women wi...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/57857
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVES:The aim of the study was retrospective analysis of osteoporosis risk in menopausal women. DESIGN:Retrospective analysis of bone mineral density of 2733 women was performed between 1997 - 1999 year. MATERIAL AND METHODS:Retrospective analysis of bone mineral density of 2733 women aged 16 to > 68 by quantita...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2005-08-01 00:00:00
abstract：:Preterm labor remains to be one of the most important challenges of contemporary perinatology and constitutes the main reason of perinatal mortality and prematurity of neonates. Studies on preterm labor have confirmed the mutual interactions of several different hormonal systems while the activation of hypothalamic- p...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVES:The two functions of the lower urinary tract are the filling/storage and emptying. Similarly lower urinary tract symptoms can be subdivided. DESIGN:The aim of the study was the estimation of usefulness of present complaints-voiding history in diagnosis of lower urinary tract dysfunctions. MATERIAL AND METH...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：DESIGN:The aim of our study was estimation of frequency of occurrence endometriosis at girls operated from different indications, research of predisposing factors and estimation of selected biophysical parameters. MATERIAL AND METHODS:Material determined 14 of patients in 13 to 21 years old of life operated on account...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:The first results of laser therapy in treatment of condylomata acuminata of male reproductive organs are reported. Between November 1991 and December 1993 in Department of Reproduction, Institute of Gynecology and Obstetrics, Karol Marcinkowski University School of Medical Sciences, Poznań in nine patients with condyl...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVES:The objective of the current research is to compare hormonal, metabolic and ovarian stromal blood flow outcomes in smoking versus non-smoking polycystic ovary syndrome (PCOS) patients. MATERIAL AND METHODS:79 PCOS women (Group 1) and 79 healthy subjects (Group 2) were recruited. Both groups were subdivided ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2020.0041
更新日期：2020-01-01 00:00:00
abstract：:Concentrations of two acute phase proteins: alpha 2-macroglobulin (alpha 2M) and transferrin (Tf) as well as glycosylation profiles of alpha 2M and Tf were studied in sera samples from 13 patients suffering from ovarian cancer. In the observed group of patients with ovarian cancer in whom the progression of disease wa...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:A review of the literature for searching of biochemical marker of endometriosis is presented. The investigations with CA 125, antiendometrial antibodies, placental protein 14 and others have not established a sensitive screening test for predicting endometriosis, especially in early stages of the disease. Most authors...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-01 00:00:00
abstract：:The influence of hormone replacement therapy (HRT) on coagulation system has not been completely explained yet. We measured plasma activities of antithrombin III, protein C and protein S before and after 6 and 12 months of HRT in 48 postmenopausal women. HRT consisted of transdermal estradiol and orally medroxyprogest...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：UNLABELLED:Cervical incompetence is one of the causes of preterm delivery. Ultrasound examination of the cervix has given the evidence that cervical shortening, dilatation of internal cervical os and funneling observed long before term are the warning signs of preterm delivery. Early diagnosis and treatment may serve b...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：UNLABELLED:The aim of the study was to compare frequency of four gynecological operations: myomectomy, tubal surgery, cystectomy and operative management of ectopic pregnancy, performed by laparotomy or laparoscopy, by the same team of surgeons. In the years 1994-1997 in Division of Reproduction Poznań University Medic...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVES:The present study aims to investigate the role of oxidant-antioxidant status in young women with polycystic ovary syndrome (PCOS). MATERIAL AND METHODS:Seventy-one women with PCOS and 53 healthy controls are compared in aspect of demographic characteristics, biochemical data, hormones, and oxidant-antioxida...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2016.0079
更新日期：2016-01-01 00:00:00
abstract：:Irradiation of cancer diseases with intracavitary applicator makes impossible visual control of applicator's position during the process of irradiation. In this paper example applicator moves during the treatment are presented and their influence to dose distribution especially in reference points is discussed. Verifi...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:The aim of the study was to define minimal conditions necessary to isolate human spermatozoa using their swim-up potential. The efficiency of the isolation of spermatozoa from seminal fluid was tested after 1 hour incubation at 37 degrees C of seminal plasma together with isolation mediums, at the volume proportion 2:...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to evaluate hormonal contraception use in women with epilepsy and to assess the risk of potential interactions between contraceptives and antiepileptic drugs (AEDs). MATERIAL AND METHODS:Data on hormonal contraception were obtained prospectively in women of childbearing age treated ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2019.0010
更新日期：2019-01-01 00:00:00
abstract：:This paper presents a case of a pregnant woman who was admitted to the obstetrics and gynecology department because of a new onset of uncontrolled diabetes in 27 weeks gestation. The maternal and fetal diabetic complications suggested a chronic character of the disease which must have been undiagnosed before pregnancy...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVES:The differences exist in concerning the estimation of number and histopathological type of ovarian tumors in pregnancy. MATERIAL AND METHODS:From all 41,661 labours which took place in our Institute between 1990-2000 retrospective analysis of medical documentation of 11,050 caesarean sections (CS) as well a...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-04-01 00:00:00
abstract：OBJECTIVES:The evaluation of sexual life after hysterectomy is still controversial. DESIGN:The aim of the study was to analyse the impact of hysterectomy on frequency and quality of the woman's sexual life. MATERIAL AND METHODS:The total of 539 women operated in II Department of Obstetrics and Gynecology in 1990-2000...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
abstract：OBJECTIVES:The study aimed to assess the associations between circulating vaspin levels and nutritional status (assessed on tha basis of BMI) as well as insulin resistance in PCOS. MATERIAL AND METHODS:Eighty-seven PCOS women, 48 obese and 39 normal weight, were enrolled in the cross-sectional study. Seventy-two Non-P...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2020.0056
更新日期：2020-01-01 00:00:00
abstract：:We report a case of a 6-week cervical pregnancy successfully treated with systemic methotrexate and gestational sac biopsy with 15%-calcium chloride solution injection. Serial monitoring of human chorionic gonadotropin levels, combined with ultrasound examinations, confirmed spontaneous miscarriage. Applied treatment ...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVES:The aim of our study was to determine the factors associated with higher incidence of trophoblastic tumours following complete hydatidiform mole. MATERIAL AND METHODS:Epidemiological and clinical factors were studied in eighty five patients with complete hydatidiform mole evacuated from 1973 to 1997 in Depa...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：:Cyclopia is a deformation of the facial skeleton with one eye orbit formed in the place where both eyes should be present. As a result of hypoplasia there is absence (hypothesized loss) of central nervous system structures. Teratogenic factors leading to the occurrence of this anomaly may include irregular cholesterol...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-03-01 00:00:00
abstract：:Venous insufficiency can be defined as a fixed venous outflow disturbance of the limbs. It is caused by the malfunction of the venous system, that may or may not be associated with venous valvular insufficiency and may involve the superficial or deep venous system of the lower limbs, or both. The CEAP scale includes c...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/1540
更新日期：2013-01-01 00:00:00
abstract：:Endometrial cancer is one of the most frequently diagnosed malignant neoplasms among women. In Poland, it is in the fourth place in terms of incidence. The highest morbidity concerns women aged 50-70 years, however it may also appear in women in their reproductive period. Endometrial cancer concerns about 3% of premen...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is a common complication of pregnancy In the course of pregnancy elevated levels of hormones and other proteins having insulin-antagonistic effects lead to higher insulin resistance in peripheral tissues, followed by hyperinsulinemia. Risk factors for the development of GDM have bee...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/2429
更新日期：2015-05-01 00:00:00
abstract：UNLABELLED:Uterine sarcomas are heterogeneous malignancies, both clinically and histologically. The process of oncogenesis depends on gene mutations and uncontrolled mitotic cell division that is promoted by blocking pathways of apoptosis. Caspase 9 and p53 protein play an important role in the process of cell apoptosi...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1778
更新日期：2014-08-01 00:00:00
