Abstract：
OBJECTIVE:Interleukin-6 (IL-6) is a specific marker of early onset infections in the newborns. In recent years it has been suggested that in regulations of IL-6 activity could play a role the genetic polymorphism (-174G/C) in the promoter region of the gene coding for IL-6. The aim of our study was to analyse the frequency of -174G/C polymorphism of interleukin-6 gene as a genomic marker for individuals at an increased risk of early onset neonatal infection as result of intra-amniotic infection (IAI). MATERIAL AND METHOD:A prospective study was conducted in 62 newborns treated in University Hospital tertiary neonatal intensive care unit. Intrauterine infection was diagnosed in 21 children and 41 neonates comprised control group. In the both groups we have analysed -174G/C polymorphism in the gene coding IL-6 using PCR/RFLP (polymerase chain reaction/restriction fragment length polymorphism) assays. RESULTS:We have observed the overrepresentation of homozygous genotypes -174C/C in the investigated group (9.5% vs. 7.3% in the controls). The frequency of heterozygous genotypes -174G/C was higher in investigated group 61.9% than in controls 56.1%. Homozygous wild type genotypes for -174G/G were detected in 28.6% and 36.6% in investigated group and controls, respectively. These proportions were consistent with the Hardy-Weinberg equilibrium. Analysing allelic frequency we have noticed overrepresentation of -174C alleles in the investigated group (40.5% vs. 35.4% in the controls, O.R. = 1.24, n.s.). CONCLUSION:The presence of the C allele in the -174 position in the gene coding for IL-6 could play a role in the pathology of neonatal infection following IAI in the mother and probably is connected with decreased of immunological reaction.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Wojsyk-Banaszak I,Seremak-Mrozikiewicz A,Szczapa J,Drews K,Zandecka-Dziubak J,Mrozikiewicz PMkeywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
127-34issue
2eissn
0017-0011issn
2543-6767journal_volume
76pub_type
杂志文章abstract：UNLABELLED:The purpose of our study was to analyze the efficacy of serum C-reactive protein (CRP), white blood cell count (WBC) and erythrocyte sedimentation rate (ESR) serial evaluations in the prediction of chorioamnionitis in cases of premature rupture of membranes (PROM). MATERIALS AND METHODS:A group of 80 patien...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：METHOD AND RESULTS:Between 1993 and 2000, 7529 patients underwent cesarean section (24.3% of 31,798 delivering women) at University Hospital in Poznań. There were 52 cases of simultaneous adnexal surgery among them because of ovarian tumors (1 case/144 abdominal deliveries; 1 case/612 pregnancies). In 43 cases tumor wa...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-04-01 00:00:00
abstract：:Three cases of small cell carcinoma of the ovary are presented. Attention to diagnostic difficulties, extremely aggressive course and low sensitivity to oncologic treatment was paid. ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:It was described two cases of vulvar melanoma malignum. Both women after primary radical treatment, unfortunately died. It was discussed the classification of melanoma malignum, the efficiency of treatment nowadays and the problems in diagnosis. General results of treatment are poor. It is due to tendency for spreadin...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVES:Histones are involved in process of proliferation and differentiation of the cells. In many lesions the expression of mRNA of histones is a marker of proliferation. The expression of kinin receptors B1 and B2 coexist with inflammatory processes, but in some studies the expression of these receptors was found...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：:The most important benefit of tocolysis is a 48-hour prolongation of gestational age in order to administer corticosteroids to reduce perinatal mortality and morbidity as well as, if necessary to gain time for "in utero" transfer to a tertiary centre with neonatal facilities. The tocolytic agents used in clinical prac...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2010-02-01 00:00:00
abstract：:We analysed the indications to myomectomy in females in reproductive age and estimated efficasy of this treatment. 112 patients aged 23-45 were analysed. Most common indication to this procedure were: menorrhagia--45.54%, myoma found at gynecological examination--21.43%, adnexal mass--20.54% and pelvic pain--15.18%. 5...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：AIM OF THE PAPER:Comparison of conventional cytodiagnostics with molecular identification of DNA and mRNA HPV HR, immunocytochemical test for suppressor protein P16 and nuclear Ki 67 to detect cervical pathology screening of the division to LG SIL and HG SIL. MATERIAL:630 Pap smears were taken from women with suspecte...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：:Diagnostic microlaparoscopy was performed on 30 patients aged 17-41. Indications++ for these procedures were: sterility (17), tumor of the ovary (5), endometriosis (3), uterine myoma (2), pelvic pain syndrome++ (1), carcinoma of the ovary--second look procedures (1), operative hysteroscopy (1). During these procedures...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVES:The aim of the study is to determine the results of our initial experience of 32 cases who underwent single incision total laparoscopic hysterectomy MATERIALS AND METHODS:Thirty-two patients who underwent transumbilical single incision total laparoscopic hysterectomy between March 2009 and February 2011 wer...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：:Small intestinal tumors are relatively rare, and notoriously difficult to diagnose. In our case 64 years old female was operated because suspicion of ovarian tumor. The complained on recurrent gastrointestinal bleeding. An arteriogram of superior mesenteric artery revealed arteriovenous malformation in the distal part...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:The ultrasound, serum beta-HCG and progesterone titres are widely used to assess the risk of miscarriage at the early stages of pregnancy. Though very useful, they are not considered as satisfactorily accurate predictors of imminent abortion during the first three months of pregnancy. AIM OF STUDY:Prospecti...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:The study presents the frequency of occurrence of newborn haemolitic disease caused by Rh (D) system incompatibility in the years 1980-1999. Serological incompatibility prophylaxis was introduced in 1980. Routine use of anti-D immunoglobulin has led to a significant reduction in the number of newborns with haemalitic ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-08-01 00:00:00
abstract：:Preterm labor remains to be one of the most important challenges of contemporary perinatology and constitutes the main reason of perinatal mortality and prematurity of neonates. Studies on preterm labor have confirmed the mutual interactions of several different hormonal systems while the activation of hypothalamic- p...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2014-02-01 00:00:00
abstract：:The hysteroscopic evaluation of uterine openings in 23 sterile women was described. The attention was paid to morphological features of obliterated uterine openings. The hysteroscopic examination of structural changes located in uterine openings seems to be a reliable method for evaluation of potency of oviducts. This...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：INTRODUCTION:Endometrial carcinoma is a common malignancy of the female genital tract. There is a strong correlation between myometrial invasion and clinical prognosis. Increasing myometrial penetration is associated with an increasing risk of pelvic and para-aortic lymph node metastasis, adnexal metastasis, positive p...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：:To make use of antigonadotropin and antiproliferating action of the synthetic analogs of GnRH there was applied this decapeptide in 33 patients with ovarian cancer who were treated traditionally by chemotherapeutics PAC and radiotherapy. The monitoring of treatment was supported on the clinical opinion of the whole an...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to assess the concordance between the preoperative endometrial sampling and microscopic examination of the hysterectomy specimens in patients surgically treated for atypical endometrial hyperplasia and endometrial carcinoma. MATERIAL AND METHODS:We analysed a group of 204 patients, ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2016.0031
更新日期：2016-01-01 00:00:00
abstract：:The aim of the study was estimation of endocrinological function of placenta in pregnancy complicated by GDM. The study were performed on a group 13 women with GDM and 14 women in normal pregnancy. All women with GDM were treat by diet and intensive insulinotherapy with self monitoring levels of glucose. In women with...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:The influence a few factors on prognosis on 5-th year survival has been estimated in 367 patients with endometrial cancer with stage I, II and III disease which underwent surgery and radiotherapy. The stage is the most important and competent authority indicators of prognosis on 5-th year survival, among prognostic va...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：OBJECTIVES:Pregnancy induced hypertension is believed to be a state of neutrophil overactivity, however all previous studies were done on isolated cells. DESIGN:To study neutrophil activity in whole blood of PIH women. MATERIALS AND METHODS:Neutrophil activity was estimated without isolation, in peripheral whole bloo...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:The aim of study was the evaluation of generating the IL-10 by peripheral blood lymphocytes in women with endometriosis according to the stage of of the disease. Cytokine was estimated by immunoenzymatic method Elisa. The generation of IL-10 by peripheral blood lymphocytes was lower in patients with all stages of endo...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:We presented the course of 1300 family deliveries and their comparison with the control group. We stated the elongation of the first stage of delivery (correspondingly 7 hours 10 minutes and 4 hours 10 minutes) and the second stage of delivery (70 minutes and 25 minutes). At the same time we observed that the obstetri...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to compare caffeine and paraxanthine concentrations in venous blood of pregnant women and in the umbilical cord blood of their newborns. MATERIALS AND METHODS:Pregnant women who gave birth at the Clinic of Obstetrics, Gynecology and Oncology 2nd Faculty of Medicine, Medical Universit...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1760
更新日期：2014-07-01 00:00:00
abstract：AIM:The aim of the following work was to assess three-level selective perinatal care in Polish voivodeships in 2008 on the basis of the following parameters: birth rates as well as perinatal death rates, divided into three classes of neonatal weights, in hospitals on each of the three levels. The goal of selective peri...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
abstract：:The purpose of the study was to compare indications for curettage directly after delivery with histologic findings. Only in 51% there was a histologic confirmation of placental or membrane tissue. Residences indications of the suspected retained placenta were wrong in 70% cases. The curetting of 75% of the patients ex...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:Fetal face is the key anatomical location, both psychologically and clinically for the mother and the clinician. Ultrasound prenatal examination of the maxillofacial region allows to evaluate the fetal face in the first weeks of gestation. In ambulatory intravaginal ultrasound, sensitivity of the facial defect detecti...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/1643
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to determine whether anhydramnios affected the duration of medical abortion in cases with various indications as compared to cases with normal amniotic fluid volume. MATERIAL AND METHODS:Patients who were admitted to our clinic because of medical abortion between January 2010-Decemb...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2016.0058
更新日期：2016-01-01 00:00:00
abstract：:Freezing of the human embryos has been routinely used in the world for over 10 years in the treatment of infertility by the ART. Excessive fertilized oocytes and embryos can be frozen and preserved in the temperature of liquid nitrogen. The risk of multiple pregnancies is reduced and enhancement of pregnancy rates can...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVES:The object of our study was a long-time presence of a foreign body in an episiotomy scar. STUDY DESIGN:A case of 46-year old woman with a palpable tumour in a perineal region is described. RESULTS:This false tumour was caused by a surgical needle which was left in the body of the patient 19 years ago durin...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
