Smoking reduces ovarian stromal blood flow in polycystic ovary syndrome patients.

Abstract:

OBJECTIVES:The objective of the current research is to compare hormonal, metabolic and ovarian stromal blood flow outcomes in smoking versus non-smoking polycystic ovary syndrome (PCOS) patients. MATERIAL AND METHODS:79 PCOS women (Group 1) and 79 healthy subjects (Group 2) were recruited. Both groups were subdivided according to their smoking habits. Ovarian stromal blood flow was assessed with pulsatility and resistance index for both ovaries and compared among smoking women. RESULTS:The smokers in the PCOS group had statistically significant higher levels of pulsatility and resistance index in both ovaries compared to nonsmoker PCOS patients (p < 0.001). Comparison of ovarian stromal blood flow indexes shows that pulsatility and resistance index for both ovaries is statistically significantly high in smoking healthy patients compared to the nonsmoking group (p < 0.001). There is a positive correlation between smoking and free androgen index (r = 0.866, p < 0.001) for PCOS patients and healthy women. CONCLUSIONS:Smoking reduces ovarian blood flow in PCOS patients and healthy subjects. Smoke components effect the vascular structure and form endothelial injuries that may reduce ovarian tissue perfusion. In this study, the positive correlation between smoking and free androgen index shows that the main effect of smoking on ovarian blood flow may be through androgen metabolism.

journal_name

Ginekol Pol

journal_title

Ginekologia polska

authors

Emekçi Özay Ö,Özay AC

doi

10.5603/GP.2020.0041

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

201-206

issue

4

eissn

0017-0011

issn

2543-6767

pii

VM/OJS/J/66124

journal_volume

91

pub_type

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